Malaysian Healthy Ageing Society Workshop Okinawan Lifestyle- Then - - PowerPoint PPT Presentation

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Malaysian Healthy Ageing Society Workshop Okinawan Lifestyle- Then - - PowerPoint PPT Presentation

Jul 11, 2023 125 likes •698 views

Organised by: Co-Sponsored: Malaysian Healthy Ageing Society Workshop Okinawan Lifestyle- Then and Now Makoto Suzuki, M.D.& Ph.D. Makoto Suzuki, M.D.& Ph.D. Professor Emeritus, University of the Ryukyus Professor Emeritus, University

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Organised by:

Malaysian Healthy Ageing Society

Co-Sponsored:

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Okinawan Lifestyle- Then and Now

Makoto Suzuki, M.D.& Ph.D.

Professor Emeritus, University of the Ryukyus Chief Director, Okinawa Research Center for Longevity Science President, Okinawa Health and Longevity Research and Development Center

Makoto Suzuki, M.D.& Ph.D.

Professor Emeritus, University of the Ryukyus Chief Director, Okinawa Research Center for Longevity Science President, Okinawa Health and Longevity Research and Development Center

Workshop

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Discussion Items

  • 1. Regional longevity indices
  • 2. Biomedical analysis for longevity
  • 3. Okinawa way (program)
  • 4. Longitudinal cohort study of

Okinawa way

  • 5. Dark sign of Okinawa longevity
  • 6. Not longevity but chouju
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  • 1. Regional longevity indices

1) Average life expectancy 2) Centenarian’s rate

Discussion Items

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All Cause Mortality in Okinawa and Japan

5000 10000 15000 20000 60-64 65-69 70-74 75-79 80-84 85-

Age Group Mortality per 100,000/yr

O K I N A W A J A P A N

stratum

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Q ui uinta tannua ual tr trend of average life expecta tancy betw tween O kinawa wa and Japan

70 72 74 76 78 80 82 84 86 88 90 1975 1980 1985 1990 1995 2000 2005 years old Female Okinaw Female Japan Male Okinawa Male Japan

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Biannual years trend of centenarians rate (1/105) between Okinawa and Japan （1970～2006）

Okinawa Japan 0.00 10.00 20.00 30.00 40.00 50.00 60.00 1970 1972 1974 1976 1978 1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 年 割 合 沖縄 日本 Okinawa ◆ Japan ■

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  • 1. Regional longevity indices
  • 2. Biomedical analysis for

longevity

Discussion Items

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Personal survey design

  • n the spot ①
  • Background life history

Birth, school, wedding

  • Family history (pedigree)
  • Social background

Occupation , finance ,religion

  • Anthropometric
  • Character
  • Past medical history
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Personal survey design

  • n the spot ②
  • Present physical and mental status
  • Clinical examinations

Urinalysis , Blood analysis , Stool tests , ECG , PWV , Echogram , EEG , MMSE

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Comprehensive Clinical Charts of Okinawa Centenarians (1976-2011)

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Prevalence of ＨＬＡｰＤＲ９ and ＤＲ1 in Okinawa Centenarian

10 10 20 20 30 30 40 40 ＤＲ1 ＤＲ９ Centenarian septuagenarian

百 82 対159 百 82 対159

フ ェ ノ タ イ プ

％

P＜0.0005 P＜0.005

人

phenotype CE CE SE SE CE SE

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Age fluctuation of Serum DHEA-S (F) YO

DHEA-S : Dehydro epiandrosterone sulfate

μｇ/ dl Age fluctuation of Serum DHEA-S (F) μｇ/ dl Age fluctuation of Serum DHEA-S (F) μｇ/ dl YO

DHEA-S : Dehydro epiandrosterone sulfate

Age fluctuation of Serum DHEA-S (F) μｇ/ dl

DHEA-S : Dehydro epiandrosterone sulfate

YO

DHEA-S : Dehydro epiandrosterone sulfate

Age fluctuation of Serum DHEA-S (F) YO

DHEA-S : Dehydro epiandrosterone sulfate

μｇ/ dl Age fluctuation of Serum DHEA-S (F) YO

DHEA-S : Dehydro epiandrosterone sulfate

μｇ/ dl Age fluctuation of Serum DHEA-S (F) YO

DHEA-S : Dehydro epiandrosterone sulfate

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DHEA-S : Dehydro epiandrosterone sulfate ★ Male

★ Female

★ ★ ★

Age fluctuation of DHEA-S and Cortisol ★ Male

★ Female

Age fluctuation of DHEA-S and Cortisol DHEA-S : Dehydro epiandrosterone sulfate ★ Male

★ Female

Age fluctuation of DHEA-S and Cortisol DHEA-S : Dehydro epiandrosterone sulfate ★ Male

★ Female

Age fluctuation of DHEA-S and Cortisol

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“Japanese Centenarian”

Medical research for the final stage of the human aging

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Discussion Items

  • 1. Regional longevity indices
  • 2. Biomedical analysis for longevity
  • 3. Okinawa way (program)
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Various overseas versions of “Okinawa Program”

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Four main items for successful longevity (Okinawa Program)

1.Dietary Culture

  • 2. Physical Activity
  • 3. Self-Help Manner
  • 4. Mutual Help Custom
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Four main items for successful longevity (Okinawa Program)

  • 1. Dietary Culture
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Goya champloo, stirfried bitterguard with soybean curds

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Boiled sponge cucumber with soybean paste

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Boiled porkchops with skin, seaweed and konjak with soy sauce

<Cooking way>

Modern

(microwave) cholesterol triglyceride

Traditional

(pot, simmer) Collagen elastin

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Four main items for successful longevity

  • 1. Dietary Culture
  • 2. Physical Activity
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Original of his income and joy

Seiryu Toguchi in his farm

M 102 years old

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Four main items for successful longevity

  • 1. Dietary Culture
  • 2. Physical Activity
  • 3. Self-Help manner

for physical, mental, social and spiritual independence,（health） by keeping worthiness of one’s life and lasting lively role for one’s family and society

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Thorough Medical check up in Medical examination cars

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Ugan: Praying in front of the family altar niching her ancestor’s memorial

tablets, put her hands together, expressing reporting her family daily events expressing her thanks and asking divine protection and prosperity for her family.

Keep one’s role for her family

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Four main items for successful longevity

  • 1. Dietary Culture
  • 2. Physical Activity
  • 3. Self-Help manner
  • 4. Mutual Help Custom
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Reaping sugar canes by vicinity joint scheme in the village community farm

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Get-together meeting for their friendship and mutual help, class reunion of 88 years old elementary school graduates

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Discussion Items

  • 1. Regional longevity indices
  • 2. Biomedical analysis for longevity
  • 3. Okinawa way (program)
  • 4. Longitudinal cohort study of

Okinawa way

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Okinawa Life Experience Seminar

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Cooking steamed rice with mugwort by Okinawa life experience seminar

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Morning Exercise

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Meditation Practice

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Past 1 year Changes of Biomarker levels in Cohort Group at Okinawa Life Intervention

（n＝5）

Pre- Past 1 year period

significant difference

Standard level DHEA-S (ng/mL) 1738.6±752.37 1696.6±570.57 n.s.

M :140-2240 F: 50-1000

Estradiol （pg/mL） M 45.00±4.35 29.90±5.18 p＜0.05 20-59 F 15.75±2.48 10.00以下 n.s.

25-350（end of follicular phase） 9-230（luteal phase ）

SOD Activity （U/mL） 4.00±3.08 4.48±3.24 n.s. ― Homocystine （nmol/ｍL) 10.52±2.55 10.72±2.11 n.s 3.0-14 Total Hydroxyproline （μmol/L） 48.60±3.50 43.00±4.18 n.s. ― Free Hydroxyproline （μmol/L） 11.77±3.83 9.6±3.91 n.s. ―

DHEA-S : Dehydro epiandrosterone sulfate SOD : Superoxide dismutase

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Discussion Items

  • 1. Regional longevity indices
  • 2. Biomedical analysis for longevity
  • 3. Okinawa way (program)
  • 4. Longitudinal cohort study of

Okinawa way

  • 5. Dark sign of Okinawa longevity
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Dark sign of Okinawa Longevity

  • 1. Increased of Obesity
  • 2. Increased of Dependent elderly
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Dark sign of Okinawa Longevity

  • 1. Increased of Obesity
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Mortality rate differences between Japan and Okinawa in 2000

（Nr./105）

Okinawa

(male)

Japan

(male)

Okinawa

(female)

Japan

(female) (Years of age)

by sex and every 20 years-of-age stratum

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Time Trend BMI 70 yrs and older between Okinawa and Japan

18 19 20 21 22 23 24 25 1949 1975 2000 Female Okinawa Female Japan Male Okinawa Male Japan Reference : Okinawa Prefectural Government

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Dark sign of Okinawa Longevity

  • 1. Increased of Obesity
  • 2. Increased of Dependent elderly
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10 20 30 40 50 60 ADL平均値

※ ※ ※※

※ p＜0.01 ※※ p＜0.005

1970’s

n=43

1980’s

n=99

1990’s

n=109

2000’s

n=99 (2000-04)

Decennial trend of of Total ADL Scores among Centenarians

ADL scores

Decrease of healthy and active, increase of unhealthy and frail due to improved medical care.

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Discussion Items

  • 1. Regional longevity indices
  • 2. Biomedical analysis for longevity
  • 3. Okinawa way (program)
  • 4. Longitudinal cohort study of

Okinawa way

  • 5. Dark sign of Okinawa longevity
  • 6. Not longevity but chouju
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Not longevity but chouju

Longevity Chouju 長寿

  • Prolongation of

length of life

  • Quantity of life
  • Old men
  • How to extend

“Chronos”

  • Celebration of long

life

  • Quality of life
  • Elderly
  • How to celebrate

“Kiros”.

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Longevity → Length of life （Chronos） Mindfulness and Implementation of own role Maintenance Ikigai Worthy of life

Chouju → High QOL（Kairos）

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Society of new elder citizens, president Dr. S.Hinohara 100y’s old

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Five slogans of New elder movement

  • 1. Independence by succession of traditional culture

and well life style

  • 2. World peace by activation of war experience
  • 3. Contribution for Med. Research by offering health

information

  • 4. Communication for society members
  • 5. Praise for nature and promotion of worthy life
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Lecture “Ikigai”,Meaning of life by Dr. S.Shouchi(104 ys’ old)

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Interview and discussion between

  • Dr. S.Shouchi and Professor L.Poon
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Stand and walk on his head,92 years old

Decathlon Worthiness of life

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Panoramic view from Katsuyama farm, Nago, Okinawa

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Tomorrow of longevity study

  • 1. “Longevity”should be healthy, active, successful,

and resilient long life. 2. Judgment and measurement of active life expectancy

  • 3. Less emphasis on the study of age-associated

diseases and pathology.

  • 4. More emphasis on the study of mechanisms
  • f healthy aging in correlation between heredity and life

style.

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Wish resilient longevity luck rub off on you!

Thank you very much for your attention!