Malaysian Healthy Ageing Society The Importance Of Evidence Based - - PowerPoint PPT Presentation

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Malaysian Healthy Ageing Society

Co-Sponsored:

The Importance Of Evidence Based Herbal Medicine For Health

• Rajen. M

Holista Colltech Limited

Modern Medicine – Strengths

 Excels at emergency  Superior diagnostic  Investigative  System driven

Modern Medicine – Weaknesses

 Chronic disease  Cost  Symptom suppression  Side effects

Gaps For Complementary Medicine

 Preventive  Proactive  Cost

Ground Realities

 Movement back to Nature

• food
• dress
• health
• beauty

 Away from synthetics  Self care

Ground Realties

 Eisenberg study

• 1997
• repeated in 2002
• more visits to alternative practitioners
• out of pocket
• 75% do not tell

Situation In The United States

 Office of unorthodox medicine  National Health Institute  Orin Hatch Act  National Center for Natural Product

Research

Global Scene

 United States  Europe  Australia  China  India  Japan  Korea  Taiwan

“Oushadiam Bahunan Kshemam”

“Plants are the ultimate source of safety” Chara Samhita & Sushrutha Samhita 250BC 500AD

From Traditional Medicine

 Aspirin (Willow bark)  Morphine (Opium)  Penicillin (mould)  Cocaine (Coca tree)  Statins (Red rice yeast)  Taxol (Yew tree bark)  Tamiflu (Star Anise)

Coming From Tradition

 Ashwaganda (immune modulator)  Pepper derivatives  Quin Hau Su (Artemesin)  Curcimin  Cinnamon

Going Back To Tradition

 High cost of drug discovery  Inefficiencies of drug discovery  Challenges of new categories  High profile failure of New Chemical

Entities in late stage trials

 Innovation deficit  Re-look on highly regulated drug discovery

and approval route

New Millennium Medicine

 Personalized  Preventive  Predictive  Holistic – system biology approach

Complementing With Tradition

 New ideas  New molecules  Fresh concepts

New Opportunities

 New drugs  Drug modifiers (vehicles)  Supplements  Food ingredients  Cosmetics  Perfumery

The Possibilities

 Armentarium  Augmentation  Adjuvant  Accessory

Areas In Need

 Diabetes  Hypertension  Arthritis  Immunity disorder

Case Study: Pepper

 Traditional use: spice  Rationale: increases digestibility of food  Lead: “hot” on skin  Hint: enhance absorption  Patents on red chilli peppers

Piperine Derivative – Tuberculosis

 Based on blood levels and Area Under

Curve

 Rimfampicin – 50 dose needed  Duration of multi drug treatment – down

from 3 to six month

 Better patient acceptance and compliance

Piperine Derivative – Topical Antifungal Treatment

 Dose reduced by 75%  Kill ratio – more than 100%  In clinical setting – better patient

acceptance