SLIDE 42 The Second-Line Cascade: Management of Patients with High Viral Load in Public HIV Clinics in Durban, South Africa
Sunpath H1,2, Naidu KK3, Pillay S2, Brijkumar J2, Moosa MYS2, Msimango-Dladla P4,Marconi VC5, Naidoo K1, Siedner M. J.6,7
1. Presented at the 22nd International AIDS Conference – Amsterdam, the Netherlands
Background
- 1. Identification of patients experiencing first-line ART failure has increased rapidly as access to viral load (VL) testing improves in HIV endemic
settings.. At failure, WHO and most treatment programs recommend 3-6 month monitoring with adherence support, repeat testing, and then clinical decision making. These recommendations are complex in practice, putting patients at risk for persistent failure, disease progression, and transmission of resistant virus. We evaluated the cascade of care after first-line ART failure in three public clinics in Durban, South Africa.
Methods
1.Retrospective chart review of patients with VL >1000 copies/mL on first-line ART during 1st March - 30th June 2016 2.Estimated proportion of patients failing first-line ART who completed each stage of the care cascade including a)completion of at least one adherence counseling visit; b)repeat viral load testing; and c) return for results with maintenance on first-line ART (if repeat VL <1000 copies/mL) or change to second-line ART (if repeat VL>1000 copies/mL). 3.In secondary analyses, we assessed the proportion of individuals who completed the cascade from failure to regimen change within 90 and 180 days
Results
- 1. Of 9782 patients accessing first line ART, 452 had first-line VF. . Only 32% (143/452) of patients with first-line failure re-
suppressed or were changed to second-line (Figure).
- 2. Only 27% (117/452) and 8% (35/452) did so within 180 and 90-days, respectively
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Conclusions
- 1. Less than 1/3 patients with viremia on first-line ART were appropriately managed for virologic failure, and less than
10% were done so within 90 days
- 2. As access to VL monitoring improves in the region, efforts to strengthen care for this high-risk and critical patient
population must be prioritized to maintain individual and population-level treatment and prevention goals.
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Abstract Number: TUPEC339