L acamas L aboratories FINE CHEMICALS MANUFACTURED IN OREGON 1 - - PowerPoint PPT Presentation

L

L

acamas aboratories

FINE CHEMICALS MANUFACTURED IN OREGON

1

L

L

acamas aboratories

Company History

• Established in 1985
• Founded by Dr. Allen Erickson, current President & CEO
• Several key products started the company
• Growth and expansion every year since inception
• Privately owned with solid financial resources (i.e., self-sufficient for Capital needs)

2

4.5 Acre (1.8 Hectares) Site 3 Manufacturing Buildings 12600 ft2 (1170 m2) Office and Laboratory Facilities 4000 ft2 (370 m2) Laboratory Area 3 Warehouses 19000 ft2 (1760 m2) Raw Materials In-Process Finished Product

Site and Facilities

L

L

acamas aboratories

3

• 8 Production Lines of 1000 and 2000 gallon reactors (4000 and 8000 L)
• >32,000 gallons (120,000 L) GL, Hastelloy & SS reactors
• Hydrogenation: 500 gallons up to 300 psi
• Hastelloy C and Tantalum Overheads
• Hastelloy C Centrifuges
• Variety of dryers
• Heating and cooling from -40 to >200°C
• High capacity vacuum to <1 Torr

Production Manufacturing Capabilities

L

L

acamas aboratories

4

Distillation Capabilities

Continuous Fractional Distillation

Engineered Packing 26 Theoretical Plates High resolution High efficiency High capacity

Thin Film Distillation

Thermally sensitive materials Short contact times High vacuum, <1 Torr High capacity, 8 kg per Minute

L

L

acamas aboratories

5

Quality Systems

▪Lacamas maintains effective quality systems that:

▪ Meet customer requirements ▪ Comply with applicable current Good Manufacturing Practices (cGMP) ▪ Focus on continuous improvement

▪Quality Unit

▪ Quality Assurance

▪ OOS/Deviation Reporting ▪ CAPA Program/Internal Audits ▪ Supplier Qualification ▪ Change Control Program ▪ Validation Program

▪ Quality Control

▪ Raw Material, Intermediate and Final Product Testing ▪ Analytical Methods Development ▪ Full Analytical Capabilities including NMR

L

L

acamas aboratories

7

Technical Expertise

▪R&D and Process Development

▪ Laboratory process optimization (up to 5 Liters) ▪ Pilot front-run (400 Liters) ▪ Commercial production (up to 8,000 Liters)

▪Chemical engineers and process chemists on staff work together to scale up new processes

L

L

acamas aboratories

8

Synthetic Strengths

L

L

acamas aboratories

EtO P OTs O EtO

Phosphorous Compounds

H3C N CH3 H3CO OCH3 CH3

Alkylations

N,N-Dimethylacetamide Dimethyl acetal

Lacamas

N H3C OH

N-Methyl-3-pyrrolidinol

O2N O Cl O

Chloroformates Bromo Compounds Grignard Reagents

R

MgX

N S H3C

X -

Substituted Thiazoles

X = Cl, Br

Ph OH R OH

Halogenation Formylations

Cl H O N H CH2R' Br Br R

12

Diboc and Custom BOC Derivatives

L

L

acamas aboratories

Br NHBOC

BOC-Amines BOC-Amino acids

O O O O O

Di-t-butyl dicarbonate (DIBOC)

NH O HO O O O N H O O O

Bis-BOC-Amine

O O O O O

Dicarbonates

Lacamas

N O O

13

Visit us Online and in Portland

14 For any questions or inquiries please contact: Jim Tung, Marketing j.tung@LacamasLabs.com Office: (503) 285-0360 Mobile: (971) 808-8105

Upcoming Events: