L acamas L aboratories FINE CHEMICALS MANUFACTURED IN OREGON 1
L acamas L aboratories Company History • Established in 1985 • Founded by Dr. Allen Erickson, current President & CEO • Several key products started the company • Growth and expansion every year since inception • Privately owned with solid financial resources (i.e., self-sufficient for Capital needs) 2
L acamas L aboratories Site and Facilities 4.5 Acre (1.8 Hectares) Site 3 Manufacturing Buildings 12600 ft 2 (1170 m 2 ) Office and Laboratory Facilities 4000 ft 2 (370 m 2 ) Laboratory Area 3 Warehouses 19000 ft 2 (1760 m 2 ) Raw Materials In-Process Finished Product 3
L acamas L aboratories Production Manufacturing Capabilities • 8 Production Lines of 1000 and 2000 gallon reactors (4000 and 8000 L) • >32,000 gallons (120,000 L) GL, Hastelloy & SS reactors • Hydrogenation: 500 gallons up to 300 psi • Hastelloy C and Tantalum Overheads • Hastelloy C Centrifuges • Variety of dryers • Heating and cooling from -40 to >200°C • High capacity vacuum to <1 Torr 4
L acamas L aboratories Distillation Capabilities Continuous Fractional Distillation Thin Film Distillation Engineered Packing Thermally sensitive materials 26 Theoretical Plates Short contact times High resolution High vacuum, <1 Torr High efficiency High capacity High capacity, 8 kg per Minute 5
L acamas L aboratories Quality Systems ▪ Lacamas maintains effective quality systems that: ▪ Meet customer requirements ▪ Comply with applicable current Good Manufacturing Practices (cGMP) ▪ Focus on continuous improvement ▪ Quality Unit ▪ Quality Assurance ▪ OOS/Deviation Reporting ▪ CAPA Program/Internal Audits ▪ Supplier Qualification ▪ Change Control Program ▪ Validation Program ▪ Quality Control ▪ Raw Material, Intermediate and Final Product Testing ▪ Analytical Methods Development ▪ Full Analytical Capabilities including NMR 7
L acamas L aboratories Technical Expertise ▪ R&D and Process Development ▪ Laboratory process optimization (up to 5 Liters) ▪ Pilot front-run (400 Liters) ▪ Commercial production (up to 8,000 Liters) ▪ Chemical engineers and process chemists on staff work together to scale up new processes 8
L acamas L aboratories Synthetic Strengths O H 3 CO OCH 3 H 3 C OH N Cl CH 3 H H 3 C N CH 3 N-Methyl-3-pyrrolidinol R OH N,N -Dimethylacetamide Dimethyl acetal Halogenation Alkylations OH Formylations H 3 C Lacamas R MgX X - Ph N S Grignard Reagents Substituted Thiazoles X = Cl, Br Br CH 2 R' O O 2 N EtO O R P OTs N EtO H O Cl Br Phosphorous Compounds Chloroformates Bromo Compounds 12
L acamas L aboratories Diboc and Custom BOC Derivatives Lacamas O O N O O O O O O O O O O Di-t-butyl dicarbonate (DIBOC) O Dicarbonates HO NH O O O O NHBOC Br O N O H BOC-Amines BOC-Amino Bis-BOC-Amine acids 13
Visit us Online and in Portland For any questions or inquiries please contact: Jim Tung, Marketing j.tung@LacamasLabs.com Office: (503) 285-0360 Mobile: (971) 808-8105 Upcoming Events : 14
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