IVF 2021 OPTIMISTIC FUTURE? MUDr. tpn Macha, Ph.D. IVF Clinic, - - PowerPoint PPT Presentation
IVF 2021 OPTIMISTIC FUTURE? MUDr. tpn Macha, Ph.D. IVF Clinic, Olomouc IVF 2018 Around 2,4 million ART cycles are estimated each year, with about 500 000 babies born. 2-6% live births in Europe by ART. World data analysis
Human Fatemi, 8th IVIARM Congress, Palma, 2019
Norbert Gleicher Center Human Reproduction, New York, N.Y., USA; Foundation for Reproductive Medicine, New York, USA; Stem Cell Biology and Molecular Embryology Laboratory, The Rockefeller University, New York, N.Y., USA;
patients.
15% 20% 25% 30% 35% 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
Live Birth per Fresh ART Cycle (%)
U.S. annual live birth rates following autologous IVF cycles 1995 to 2014
https://npesu.unsw.edu.au/, accessed December 25, 2018.
Society Annual Reports (CARTR) https://cfas.ca/cartr-annual- reports/, accessed November 20, 2018-
Reproduction.
Reproduction( www.redlara.com, accessed November 20, 2018).
clinics-success-rates.html), accessed November 20, 2018 and CDC for United States.
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
% SET in Fresh ART Cycles
Australia and New Zealand Canada Japan Latin America UK US
0% 2% 4% 6% 8% 10% 12% 14% 16% 50000 100000 150000 200000 250000 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
Live Birth per Fresh ART cycle (%) Total Fresh Autolgous Cycles
Japan
Cycles Live Birth Rate
0% 5% 10% 15% 20% 25% 5000 10000 15000 20000 25000 30000 35000 40000 45000 50000 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
Live Birth per Fresh ART cycle (%) Total Fresh Autolgous Cycles
Australia and New Zealand
Cycles Live Birth Rate
Table 1. Newly introduced additions that may have adversely affected IVF outcomes Embryo selection Extended embryo culture to blastocyst Elective single embryo transfer (eSET) Closed embryo incubation systems with time lapse imaging Preimplantation genetic screening (PGS)* Mild ovarian stimulations “Mini-IVF” Natural cycle IVF Patient-friendly IVF Cycle interruptions All freeze cycles with frozen-thawed cycle to follow Embryo banking with combined frozen-thawed cycle to follow
Bart Fauser University Medical Center Utrecht, Department of Reproductive Medicine
infertility guidelines.
Juan Antonio Garcia Velasco IVIRMA , Director of IVF Madrid
stimulation response
Hershkop et al, RBMO, 2017
Treatment add ons 3.3. One area of work that we have already started is treatment ‘add ons’ which have become a feature of many IVF services. Increasingly, patients are being offered a variety of treatments – including drug regimes, methods for culturing embryos and treatment procedures – with the claim that they improve the chances of a successful pregnancy. Some patient feedback indicates that many now see such treatments as an indicator of a good service. Yet the evidence base for many of these treatments is weak. Our new website will give information about these add ons and we are discussing collaborative work with the professional bodies and patient groups. How might we want to progress this work further in 2017-20? Treatment costs 3.4. We are not an economic regulatora, nd have no direct levers to pull around the cost of treatment, but this is one of patients’ top concerns. Although our new website won’t list prices for each clinic, it will give patients information about the range of costs across UK clinics. It will also give patients a chance to give feedback on the patient ratings feature about whether they paid what the clinic estimated treatment would cost.
Harper J. et al., HumReprod, 2017
Daily Mail, Fertility Clinics accused of covering up potentially fatal side effects of IVF