ISBT WORKING PARTY ON RARE DONORS FRANCE Have a national Rare Donor - PowerPoint PPT Presentation

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ISBT WORKING PARTY ON RARE DONORS FRANCE Have a national Rare Donor Program: Yes Number of Donors in Database: 1780 D efinition of a donor: 1 cryopreserved RBC unit Definition of Rare: Prevalence < 1/250 Legal definition, which only

ISBT WORKING PARTY ON RARE DONORS FRANCE Have a national Rare Donor Program: Yes Number of Donors in Database: 1780 D efinition of a donor: ≥ 1 cryopreserved RBC unit Definition of Rare: Prevalence < 1/250 Legal definition, which only considers the rare specificity prevalence (not the associated type) Number of Frozen Rare Cells: 6315 (-80°C) Dr Thierry Peyrard - INTS/CNRGS - Paris 1
S ISBT WORKING PARTY ON RARE DONORS FRANCE How are Rare Donors found?: - Extended phenotype in 15% of new blood donors: Rh (C,E,c,e), Kell (K), Duffy (Fy a ,Fy b ), Kidd (Jk a ,Jk b ), MNS (M,N,S,s) Optional: k and Lu a typing if K+ or Lu(b+), respectively - Mass screening RBC typing (e.g. Yt(a-) and Vel-) - Study of patients with an antibody to a high-prevalence antigen - Incident finding in a patient when extended phenotype or genotype is performed - Sibling testing Dr Thierry Peyrard - INTS/CNRGS - Paris 2
ISBT WORKING PARTY ON RARE DONORS FRANCE Number of Rare Donor units used per year: 309 RBC units (56 patients) in 2011 4.7 RBC units/million inhabitants/year Shipping Outcome form used?: No Dr Thierry Peyrard - INTS/CNRGS - Paris 3
ISBT WORKING PARTY ON RARE DONORS FRANCE Most difficult types to find: U- O, D-C-E-, K-, Fy(a-b-), Jk(b-) (4 donors) Fy(a-b-) O, D-C-E-, K-, Jk(b-), S-s+, Js(a-), VS- (8 donors; 3 donors if M- and 1 donor if M-,Do(a-)) Vel- O, E-c-, K- (2 donors) Rh null (1 donor, group A) and D - - (5 donors) Hr- (5 donors) and Hr B - (11 donors) Dr Thierry Peyrard - INTS/CNRGS - Paris 4
ISBT WORKING PARTY ON RARE DONORS FRANCE Other items of interest: - No time limit in France for RBC storage at -80°C - RBC units drawn after 2005: 7-day outdate after thawing - 2007-2012: 3% of thawed RBC units shipped abroad : Austria, Belgium, Canada, Germany, Sweden, Switzerland - Cost of one rare thawed RBC unit: 400 euros (500 $), vs 200 euros for a standard fresh RBC unit Dr Thierry Peyrard - INTS/CNRGS - Paris 5

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