Immunopathophysiology COVID-19 In Kidney Diseases By Dr Davoud - - PowerPoint PPT Presentation

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Sep 24, 2023 151 likes •358 views

Immunopathophysiology COVID-19 In Kidney Diseases By Dr Davoud Esmaeili Fellowship Laboratory Medical Sciences Coronaviridae Coronavirinae subgroups Receptors Hcov-NL63 CD13( APN) Hcov-229E ACE2 PEDV(Porcine epidemic Virus) CD13

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Immunopathophysiology COVID-19 In Kidney Diseases

By Dr Davoud Esmaeili Fellowship Laboratory Medical Sciences

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Coronaviridae

Coronavirinae subgroups Receptors

α

Hcov-NL63 CD13( APN) Hcov-229E ACE2 PEDV(Porcine epidemic Virus) CD13 CCov ( Canine Coronavirus) CD13 FIPV( Feline Infectious Peritonitis) CD13

β

SARS-Cov2( COVID-19) ACE2, CD13, NANA SARS ACE2, CD13, NANA MERS DPP4 OC43 NANA HKU1 Glycans MHV( Mouse Hepatitis Virus) CEA Bcov( Bovine Coronavirus) NANA

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Coronavirinae subgroups Receptors

Ɣ

T Cov (Turkey Cov) AIBV( Avian Bronchitis Virus)

δ

D Cov (Guinea Fowl) Beluga Whale Cov Sw1 HKU11 HKU17

Torovirinae

Torovirus Baffinvirus

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Coronaviridae Classifiaction

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General characterization

RNA Sense positve Enveloped ORF 7-14 80-120 nm Diameter

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Structure

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Virus replication

penetration Release

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Replication

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Pathogenesis

Respiratory Gastroenteritis Neurotrpic Osteotropic Liver Cardiomyopathy Hypoxia Skin acne Conjunctivitis

AKI

Risk Factors: Age ≥ 65 Daibetic Immunocompromised BMI Dysfunction Kidney, Liver, Lung

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COVID-19 and Nephropathy

CYTOKINE STORMY Immune COMPLEX Infiltration MQ, Lymphocyte, Renin-Angiotensin, Aldostron Sepsis Syndrome AKI hypercoagulation Hypert ension , hypote nsion

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Laboratory Tests

Cytokine Cascade IL-6 IL-1β TNFα IL-1β IL-8 Chemokines IP-10 MCP-1 Cr CRP ESR Lekopenia Lymphopenia Inflammation Ferritin D-dimer CD4

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