HYBRID pH-SENSITIVE NANOPARTICLES AS PLATFORMS FOR DELIVERY OF - - PowerPoint PPT Presentation

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HYBRID pH-SENSITIVE NANOPARTICLES AS PLATFORMS FOR DELIVERY OF - - PowerPoint PPT Presentation

Feb 04, 2023 47 likes •128 views

HYBRID pH-SENSITIVE NANOPARTICLES AS PLATFORMS FOR DELIVERY OF CURCUMIN Elena Drakalska , Denitsa Momekova, Stanislav Rangelov, Nikolay Lambov, Bistra Angelovska Introduction - Pleiotropic antineoplastic activity - Without toxicity to normal

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HYBRID pH-SENSITIVE NANOPARTICLES AS PLATFORMS FOR DELIVERY OF CURCUMIN

Elena Drakalska, Denitsa Momekova, Stanislav Rangelov, Nikolay Lambov, Bistra Angelovska

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SLIDE 2

Introduction

  • Pleiotropic antineoplastic activity
  • Without toxicity to normal cells
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SLIDE 3

Disadvantages

  • Poor aqueous solubility (11ng/ml)
  • Instability in physiological pH
  • Low bioavailability
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SLIDE 4

Approaches for optimization

  • Design of nanoparticles
  • Incorporation of curcumin into lipid

bilayer and aqueous cavity in form

  • f inclusion complex with BEC X
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SLIDE 5
  • Monomodal distribution
  • Size app.180 nm
  • Zeta potential -20mV

Results

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SLIDE 6

Figure 2. In vitro curcumin release from hybrid non pH sensitive (black) and hybrid pH-sensitive liposomes

In vitro drug release profile

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SLIDE 7

Cytotoxicity

  • MTT- dye reduction assay
  • Panel of human cancer cell lines
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SLIDE 8

These findings give us a reason to conclude that the hybrid pH-sensitive liposomal nanoparticles are promising platforms for curcumin.

Conclusion