FURTHeR Searching the Universitys data resources for clinical - - PDF document

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FURTHeR – Searching the University’s data resources for clinical cohorts

LIFT Forum Joyce A. Mitchell, PhD Assoc Vice Pres Academic Health IT March 7, 2012

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Purpose

• Support clinical and translational research
• Join data from multiple sources for retrospective
• Join data from multiple sources for retrospective

studies

• Current state: Support pre‐research questions for

feasibility analysis

– Return aggregate count information across data sources sources – Show unique and common patients across data sources

• FURTHeR went live Nov 2011, so its new.

Rationale – Cohort Finding

• FURTHeR is focused on pre‐research cohort

finding as its first effort

• Nationally, 60% of RCTS fail or require an

extension because of enrollment issues

• At UU, of 726 clinical studies since 2007:

– 25% met of exceeded stated recruitment goals – 75% failed to meet original stated recruitment

• Some of these problems are difficulties with

specifications of appropriate cohorts.

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Univ of Utah Hospitals & Clinics

The FURTHeR CTSA Mission

Clinical

FURTHeR= Federated Utah R h & T l ti l Huntsman Cancer Institute Intermountain Healthcare

Genotypic Phenotypic

Research & Translational Health e-Repository VAMC Salt Lake City UDOH Other Partners

Public health Genealogic

FURTHeR Data Sources

• UU EDW

– Data back to 1994 – Demographics: >1.5M individuals – Lab Results: 94M records – Med Orders: 9.4M records – Diagnoses: 17M records Diagnoses: 17M records – Procedures: 346K records

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FURTHeR Data Sources

• UPDBL

– Demographics: >6.5M individuals – Diagnoses & Procedures : From 3.56M hospital claims

• 1996 – present

– Cause of Death (Death Certificates): 766K records

• 1904 – present

– Birth Certificates: 2.4M records

• 1915 – 1921, 1943 – present

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– Pedigree Quality: up to 11 generations – Master Subject Index

• Links records from UU and Intermountain

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FURTHeR

Cohort statistics Record-level

• Pt. Data

Genealogies UPDBL D E M L A M E D P R O D I

EDW(s)

Ambu‐ latory Surgery Inpatient Hospital Discharges Utah Cancer Registry Birth Certifi‐ cates Death Certifi‐ cates Idaho Cancer Registry

Idaho

Idaho Cancer Registry Utah Drivers License Utah Voter Registra‐ tion M O G R A P H I C B T E S T S D O R D E R S O C E D U R E S A G N O S E S

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January 2012

9 Medicine, MD Student

FURTHeR Users

February 2012

Total Faculty/Staff: 59 Total Students: 59 Total Registered Users: 118 Total Active Users: 79 Total Number of Queries: 604 Pharmacy, PharmD Student

Faculty/Staff

School of Medicine College of Nursing College of Pharmacy Eccles Health Sciences Library Administration Huntsman Cancer Institute Biomedical Informatics, MS Student Clinical Investigations, MS Student Public Health, PHD Student Nursing, MS Student Biomedical Informatics, PHD Student 10

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FURTHeR Users (Feb 2012)

more than 10 queries apiece

• College of Nursing – 3 faculty, 2 MS students
• College of Pharmacy – 3 faculty
• College of Pharmacy – 3 faculty
• Huntsman Institute – 1 research staff
• School of Medicine – 20 faculty, staff, resident, stud

– Rheumatology ‐ Genetic Epidemiology – Public Health ‐ Ophthalmology – Pathology ‐ Utah Cancer Registry – Pediatrics ‐ CARMA Center – Neurology ‐ Clinical Epidemiology – Psychiatry ‐ Biomedical Informatics

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User Comments

• This is a Game Changer.
• This will cut 3 months off the front of my

research project.

• This will help me with recruitment by helping

me identify new subjects on an ongoing basis.

• I can identify a more appropriate set of
• I can identify a more appropriate set of

inclusion/exclusion criteria for my cohort before I submit my IRB.

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FURTHeR.utah.edu

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FURTHeR User Agreement

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www.FURTHeR.Utah.edu

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Example: GAD and IBS from UU EDW and UPDBL

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Example: Severe Pre‐eclampsia from UU EDW & UPDBL Example: Drug association with Diagnosis

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Example: Adding Lab Results and setting a value

www.FURTHeR.Utah.edu

Example – Diabetic Cataract Vs Diabetes and Cataract

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Diabetic Cataract

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Diabetes and Cataract Example

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Example ‐ Glaucoma

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Glaucoma Example

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Glaucoma and Sleep Apnea (building)

Glaucoma Example (example 1)

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Glaucoma Example Glaucoma Example – demographics 1

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Glaucoma Example – demographics 2 Glaucoma Example – demographics 3

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Glaucoma Example – demographics 4 Glaucoma Example – demographics 5

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Example – Senile Macular Degeneration

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Senile Macular Degeneration and Antihyperlipidemic Drugs

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Senile Macular Degeneration and Statins Senile Macular Degeneration and Statins

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What To Do Next?

• Register for an account
• Start querying

q y g

• Check out the FURTHeR Help Videos
• Send email for assistance to

further@utah.edu

• Send me comments or questions

– Joyce.mitchell@hsc.utah.edu

• Use it!! It can help you with your research.

Great News!!

• Health Sciences Library to have FURTHeR

i i mini‐courses

– Monday, March 19 1‐3 pm – Wed, April 18 9‐11 am

• Register on the HSL Home Page Be sure to

Register on the HSL Home Page. Be sure to get your FURTHeR account authorized ahead

• f the class.

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FURTHeR Acknowledgements

• FURTHeR Team

Ri k B d h MS

• UU EDW Team

PPR/UPDB T

– Rick Bradshaw, MS – Dustin Schultz, MS – Ryan Butcher – Andrew Iskander – Ram Gouripeddi, MD – Gina Williams

• PPR/UPDB Team
• CHPC
• Collaboration Partners

– Intermountain Gina Williams – Oren Livne, PhD – Susan Matney, RN – Scott Narus, PhD – SLC VAMC – UDOH

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