EVPRI OFFICE UPDATE ULRF Board Meeting Spring 2018 Robert S. - - PowerPoint PPT Presentation

EVPRI OFFICE UPDATE

ULRF Board Meeting — Spring 2018

Robert S. Keynton, Ph.D. Interim Executive Vice President for Research and Innovation​

L O U I S V I L L E . E D U

Making a Difference

• Impact human lives and our

community;

• Create new knowledge;
• Prepare students to exceed

the status quo in the workplace and in graduate school; and

• Advance our economy.

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Spinal Cord Injury

• Dr. Susan Harkema – Neurological Surgery

$8.7 million grant from the Christopher & Dana Reeve Foundation

• The center has three main thrusts: spinal cord

epidural stimulation (scES), which activates the neural circuits via an implanted electrode array; and adult and pediatric neuro-recovery, which investigates the potential to recover function.

Human Impact

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• Dr. Anna Faul – Kent School of Social Work

$2.5 million from the Health Resources and Services Administration

• This project develops an inter-professional

education center that educates and prepares students and professionals for this geriatric need and to improve the patient experience and clinical outcomes, reduce the cost of care, and improve the work life for those delivering care.

Geriatric Workforce Enhancement Human Impact

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• Dr. Craig McClain – Division of

Gastroenterology, Hepatology & Nutrition $11 million and $7 million grants from the National Institutes of Health

• Alcohol Research Center (ULARC) was

created to investigate mechanisms of alcohol-induced organ injury and to develop new methods of prevention and treatment.

Pictured: Researchers in McClain’s lab.

Alcohol Research Center

New Knowledge

L O U I S V I L L E . E D U

• Functional Microbiomics, Inflammation and

Pathogenicity to find new ways to fight potentially devastating diseases. Dr. Lamont, Dentistry – $11.2M grant NIH

• Novel ligand-centered electrocatalysts for the evolution

and oxidation of hydrogen, which, among other things, serves as a promising alternative carbon-free fuel. Drs. Grapperhaus & Kozlowski, Chemistry - $450K NSF

• How to connect problem-solvers around the U.S. with

leading-edge fabrication and characterization tools, instrumentation, and expertise within all disciplines of nanoscale science, engineering and technology. Dr. Walsh, Engineering – $3.7M grant NSF

Pictured: Researchers in Dr. Lamont’s lab.

Discovery Across Disciplines New Knowledge

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• Dr. Gina Bertocci

Student project

• Students helped build a robohand for

10-year-old Lucas Abraham, whose right hand was stunted at birth.

• Students learned compassion and

how to deal with people with disabilities while better understanding how their work could change a life.

Pictured: Lucas Abraham.

Robotic Prosthetics Education

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Student Successes

Carrie Benzinger B.S. Bioengineering, 2011; M.Eng 2012 Fulbright Scholar and Whitaker International Fellow

• Ms. Benzinger, Fort Wright, KY, conducted

research on the development of minimally invasive right ventricular assist devices for the treatment of heart failure at Aachen University’s Helmholz Institute of Applied Medical Engineering.

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More Student Success

Ishita Jain (BSBE 2013, MEng 2014) Whitaker International Fellow

• Ms. Jain worked as a bioengineering intern at the European Astronaut Center in

Cologne, Germany this summer. She worked with the Wyle Laboratory team to assess and quantify the efficacy of the Functional Readaptive Exercise Device for improving the condition of spine stabilizer muscles after periods of deconditioning. Patrick McClure (BSBE 2013, MEng 2014) Cambridge International Scholarship

• Mr. McClure, from Corbin, KY, received a 3-yr scholarship to complete a doctoral

degree in cognitive and brain sciences at the University of Cambridge, England. His research will focus on computational neuroscience. During his junior year he won a Barry M. Goldwater Scholarship and conducted research in computational sensing and medical robotics at Johns Hopkins University.

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• EVPRI helps researchers patent and license

their innovations for commercialization;

• This may result in new products, revenue

and startups, sometimes led by the researcher;

• In 2015, UofL ranked as one of the top 100

for awarded U.S. patents in the world.

Pictured: Dr. Geoff Clark, right.

Translational Research

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Translational ‘Superfecta' UofL is in a league of its own: we’re the ONLY university to receive some of the most prestigious translational research grants.

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Technology Transfer: 3DSIM

• UofL professors invented modeling software

for additive manufacturing;​

• Launched a company to commercialize it;​
• Sold the company to Pittsburgh-based

engineering simulation company, ANSYS Inc. in 2017 for an undisclosed sum;​

• Bought out provision of its contract with UofL

for approximately $2 million;​

• ANSYS still works with UofL on projects.

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UofL is a Carnegie Research I: Doctoral University – Highest Research Activity

Only 2.5% of all universities meet the criteria to be Carnegie R-1.

• Attract the best and brightest students (UG & Grad)
• Attract top-tier faculty
• Attract high-quality postdoctoral fellows
• Strong research universities = Leaders of innovation
• Stimulates a knowledge-based economy

Impact

How do we know we are a preeminent research university?

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Carnegie Research I Criteria

The measure of research activity for R1 status is clear.

Only 2.5% of all universities meet the criteria to be Carnegie R-1.

• Research and development expenditures in science and engineering

(S&E);

• Research and development expenditures in non-S&E;
• S&E research staff (postdoctoral students, etc.)
• Doctoral conferrals in humanities, social science, STEM fields, and
• ther fields.

By the Numbers

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National Rank R&D Expenditures 1997-2016

HB1 - #146 Period of Sustained Investment – B4B, SRI, NIH doubling, earmarks Maintained $$ - But rank static. 2016 - #112

115 Carnegie Research I: Doctoral Universities: Highest Research Activity

By the Numbers

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Research I universities attract the top students

16% 84%

R1 universities account for 16% of enrollment at all U.S. degree granting postsecondary institutions

Year Enrollment Average High School GPA Average ACT 6 yr Graduation Rate In-State Out-of- State 2000 2241 3.2 22.2 40.6% 86% 14% 2004 2307 3.4 23.6 48.60% 87% 13% 2017 2640 3.6 25.3 54.40% 79% 21%

Since becoming a research university, UofL has consistently attracted higher quality students

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Year Graduate Student Enrollment Graduate In- State Enrollment Graduate

• ut-of-

state Enrollment Total Masters Degrees Conferred Total Doctoral Degrees Conferred 1998 4434 3510 924 1127 421 2004 4798 3390 1408 1322 436 2017 4362 2496 1866 1435 509

Graduate Student Success

By the Numbers

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Total Research Expenditures

By the Numbers

Higher education R&D expenditures: FY 2016* ($ in thousands)

Institution (ACC) All R&D expenditures Rank Life sciences Rank Arts, Sciences, Social** Rank Engineering Rank Duke U. 1,055,778 10 888,830 4 64,985 37 74,746 35

• U. North Carolina, Chapel Hill

1,045,338 11 765,284 8 184,430 7 29,576 101

• U. Pittsburgh

889,793 17 747,123 9 59,008 44 41,382 75 Georgia Institute of Technology 790,706 25 23,915 166 62,689 39 558,219 2 Virginia Polytechnic Institute 521,773 43 221,801 62 29,782 83 228,281 8 North Carolina State U. 489,918 47 227,500 61 52,376 53 147,704 13

• U. Virginia, Charlottesville

397,458 56 245,218 55 53,186 52 48,815 60

• U. Miami

358,441 62 262,779 48 21,839 104 5,133 195 Florida State U. 268,288 82 37,909 147 111,930 20 46,346 63

• U. Notre Dame

202,216 104 28,458 160 58,922 45 69,954 38 Clemson U. 183,965 109 46,900 130 17,295 121 64,870 43

• U. Louisville

182,454 112 146,880 86 4,856 205 19,105 125 Wake Forest U. 170,006 120 165,939 78 3,467 234 Syracuse U. 84,651 158 8,450 231 20,635 106 18,332 129 Boston C. 54,469 193 10,996 216 23,279 101 Institution (Benchmark) Vanderbilt U. 640,842 31 495,654 26 46,070 60 66,481 41

• U. Alabama, Birmingham

537,825 42 472,114 29 11,531 157 43,359 68 Indiana U., Bloomington 508,766 45 344,005 38 84,889 31 3,164 213

• U. Cincinnati

430,579 52 340,897 39 23,821 100 34,412 93

• U. Kentucky

349,661 64 250,625 54 15,655 133 50,766 58

• U. Louisville

182,454 112 146,880 86 4,856 205 19,105 125

* Source: National Science Foundation, Higher Education Research and Development Survey, FY 2016, https://ncsesdata.nsf.gov/herd/2016/ ** Mathematics/Statistics, Physical sciences, Psychology, Social sciences

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School/College/Unit FY2013* FY2014* FY2015 FY2016 FY2017

Administrative Offices

1,992,728.00 1,859,391.95 1,999,664.00 2,086,117.00 2,329,205.00

Arts & Sciences

5,059,959.00 4,700,266.08 6,270,818.20 4,658,244.00 5,880,445.72

Business

36,357.00 50,317.46 60,050.00 30,000.00 38,290.00

Dentistry

4,888,842.92 5,324,164.78 4,256,815.49 6,085,079.00 5,410,240.00

Education & Human Dev

5,189,789.15 3,984,254.95 5,386,140.15 5,001,060.35 4,944,837.14

Kent School

4,055,306.00 4,038,331.00 4,602,047.00 5,937,420.00 6,486,822.00

Medicine

82,445,283.37 71,106,988.26 103,689,169.11 93,360,364.58 109,943,578.51

Music

0.00 86,472.00 0.00 0.00 13,000.00

Nursing

364,762.00 1,490,155.00 1,631,661.00 1,464,471.00 562,662.00

Public Health & Info Sci

4,982,696.23 1,673,694.00 1,532,514.00 3,060,082.00 3,410,576.89

School of Law

0.00 62,387.00 122,763.00 0.00 37,435.00

Speed School of Eng

13,066,877.55 9,299,316.35 7,308,770.67 12,914,820.00 8,744,809.01

University Libraries

0.00 1,238.00 0.00 0.00 1,800.00

Total $122,082,601.22 $103,676,976.83 $136,860,412.62 $134,597,657.93 $147,803,701.27

Extramural Awards by Academic Unit

By the Numbers

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Certification & Training Innovation Quality Assurance Talent Pipeline

FY2013 FY2014 FY2015 FY2016 FY2017 Clinical Trial Revenue $6,385,496 $7,080,824 $8,490,474 $10,837,350 $12,949,518

$0 $2,000,000 $4,000,000 $6,000,000 $8,000,000 $10,000,000 $12,000,000 $14,000,000 FY2013 FY2014 FY2015 FY2016 FY2017

Clinical Trial Revenue

By the Numbers

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*FY16 had a several patent portfolios that were granted/validated in foreign countries.

FY 2014 FY2015 FY 2016 FY 2017 Invention Disclosures 76 94 97 72 Patent Applications 130 101 114 103 Patents Awarded 39 36 94* 46 Patents Awarded Cumulative 260 299 335 381 License/Option Agreements 20 21 15 17 Royalties/License Income $3,999,699 $1,513,590 $343,195 $240,113 Associated Income $3,852,114 $4,609,882 $5,270,681 $6,151,128 Patent Reimbursement Income $573,581 $318,301 $330,144 $404,776 Total Innovation Related Income $8,425,394 $6,441,773 $5,944,020 $6,796,017

Innovation Metrics

By the Numbers

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Financial Solvency

• Growing as a research university leads to the

discovery of new knowledge and student success.

• It also provides financial support from extramural

sources for both direct and indirect costs of research.

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Indirect Cost Allocation Per University Policy

By the Numbers

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Indirect Cost Allocation Detail

Authorized Fixed Costs – $6.7M

• To cover costs of University Scholars Program, debt service on research facilities,

M&O of research buildings, and strategic research commitments not supported by extramural grant budgets. Research Infrastructure Funds (I-RIF & D-RIF) – $5M

• To provide funds to invest in the infrastructure that supports efforts to secure and

maintain extramurally funded research programs. President, Provost, EVPHA, and EVPRI – $2.6M

• Support equipment matching requirements, research faculty recruiting packages, and
• ther costs necessary for the research enterprise.

Transferred to General Fund – $10.6M

• Supports sponsored programs administration, EVPRI supported research centers &

institutes, compliance (COI, IRB, IACUC, EHS, Privacy), IT infrastructure, lobbyists, accounting/F&A/legal consultant fees, and central capture of funds.

By the Numbers

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Return on EVPRI Research Administration Costs

EVPRI Research Administration Infrastructure Budget Total Resulting External Funding (2017) Sponsored Programs & Compliance

$2,478,608 $134,854,183

Clinical Trials & Human Subjects Compliance

$1,657,474 $13,353,673

Technology Transfer and Innovation

$1,875,176 $6,796,017

By the Numbers

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Pilot Grants Programs – Return on Investment

Pilot grant awards for new research ideas and projects between 2007 - 2014 resulted in an average return of 1793% and a total of $171M in subsequent external funding. In FY2018, the EVPRI awarded $200,000 to fund novel ideas and projects in STEM and non- STEM fields and for undergraduate research. Award values ranged from $3k to $25k.

By the Numbers

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EVPRI Mission

• Promote and support research, scholarship

and creative activities;

• Help faculty, staff and students obtain

intramural and extramural support;

• Advocate for the value of research and

scholarly activity in the educational setting;

• Enhance the vitality of campus-based

research; and,

• Encourage the use of research to enrich

education, transfer technology and serve the community.

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EVPRI Vision

• Grow research infrastructure to elevate our

Carnegie Research I status;

• Build strategic partnerships with industry;
• Translate new knowledge to:
• Enrich the educational experience of

students;

• Facilitate economic development through

translation of innovations (Intellectual Property);

• Engage the community to improve the

quality of life of Kentucky and the nation’s citizens.

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Elevate Carnegie Research I Status

• Be creative to identify new revenue

streams/resources.

• Evaluate organizational structure, processes and

resources:

• Initiated a reorganization of the office;
• Reallocate resources – Personnel lines;
• Brainstorming – Identify new structures, improve processes.

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Previous Structure

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New Structure

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Elevate Carnegie Research I Status

• Strategically focus resources to enhance research competitiveness;
• Rebuild the research pipeline
• Recruit new research intensive faculty
• Build research infrastructure
• Invest in professional grant writers, navigators
• Partner with units to establish mentorship program for junior faculty
• Establish substantial (>$1M) internal/proof-of-concept grants programs

Institution # Proposal Development Personnel Research Expenditures

UNC 6 $1,045,338.00 VT 4 $521,773.00 UK 8 $349,661.00 FSU 4 $268,288.00 Clemson 3 $183,965.00 UofL $182,454.00

L O U I S V I L L E . E D U

Power Kids Lung Cancer Diagnosis by Breath Analysis

The Coulter Translational Partnership at UofL

$5 Million award to UofL from the Wallace H. Coulter Foundation

Highly competitive award to only 16 premier Universities Louisville, Stanford, UVA, Duke, Columbia, Johns Hopkins, USC, Missouri, Michigan, Boston U, Case Western, Pittsburgh, GA Tech, Drexel, Washington, Miami

5+ years (2012-2018) Program Goals: Translate innovations to address unmet clinical needs

Milestone driven Accelerate commercialization Stimulate medical innovation by providing gap funding and training to University innovators Promote engineer & clinician collaborations

Program Impact at UofL:

Diagnosis of Retinal Disease using OCT system Detection of Acute Renal Rejection

50+ New Collaborations between SSoE & HSC 60+ New Research Disclosures 18 Projects Funded 6 Startups from the TP Program 5 Licenses to private companies ~$3.36 Million additional external grant funding ~$2.59 Million professional investment 4 products in clinical studies

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Build Strategic Partnerships with Industry

Build strategic partnerships with industry to:

• Provide experiential learning
• pportunities for students;
• Diversify the research portfolio;
• Better serve our community through

workforce development;

RIGHT: FirstBuild and the Kindred HIVE: Examples of partnerships a research university can attract.

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Enrich the educational experience of students

Translate New Knowledge

“I was inspired by science and the excellence of knowledge present among the staff at the University of Louisville.”

• Susana Martinez

Susana Perez Martinez Soon-to-Be Ph.D. in biology

• Accepted to dental school but was “inspired” by

the research so much she decided to do her Ph.D. in Dr. Running’s Lab, paid for by a prestigious Gates Millennial Scholarship.

• She’s studying the function of genes of a

common moss species Dr. Running and his colleagues have engineered to be potentially suitable for biofuel applications.

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Facilitate economic development through translation of innovations

Translate New Knowledge

• Inscope Medical Solutions commercializes a

suction laryngoscope device based on transferred UofL technology invented at UofL Hospital;

• Licensed to UofL entrepreneurship MBA team,

who launched a company to commercialize it;

• Product now on the market with another on the

way;

• Drawing investment from prominent names like

AOL co-founder Steve Case.

Pictured: Inscope collects $100,000 investment from fund led by AOL co-founder Steve Case.

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Engage the community to improve quality of life

Translate New Knowledge

The environment’s impact on human health. Dr. Srivastava, Cardiology – $6.6M NIH Superfund

• grant. Dr. Heberle, Sociology – $721k EPA Brown

Field grant; The academic and behavior response to interventions in educational settings. Dr. Scott, Education - $800K Ky Department of Education.

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Research: Catching the Big One.

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Thank You!