Drug Information Portal in Europe: Plan information retrieval with - - PowerPoint PPT Presentation

Plan

• Introduction
• Matériels et méthodes
• Résultats
• Discussion

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Drug Information Portal in Europe: information retrieval with multiple health terminologies

Saoussen SAKJI a, b, Catherine LETORD a, Suzanne PEREIRA a, b, c, Badisse DAHAMNA a, Michel JOUBERT b, and Stéfan DARMONI a

a CISMeF, Rouen University Hospital

& GCSIS, TIBS, LITIS EA 4108, Biomedical Research Institute, Rouen. France

b LERTIM EA 3283, University of Marseille. France c Vidal Company, Issy les Moulineaux, France

Introduction

• To have precise information about drugs, an end-user should limit the

number increasingly significant of drugs confusion.

• Since several years, international on-line drug databases (e.g. Vidal

database) have been established to give to health professionals drugs information more relevant than it is.

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Objective

• The objective of this work is the creation of a bilingual drug

information portal (French/English), in a multi- terminological context

 To respond as much as possible to drug-related questions.

• Drug Information Portal (DIP) ≠ Drug Database

 Grey literature available on the Internet, mostly from institutional resources (e.g. French National Health Autority)

• Collaboration between CISMeF team and VIDAL
• Mainly funded by PSIP (Patient Safety through Intelligent

Procedures in medication) project (EU Patient Safety Program)

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Background

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• CISMeF : a quality-controlled health portal to catalogue and index the most

important resources of institutional health information in French.

• BackOffice CISMeF (before DIP) : MeSH thesaurus, including MeSH

pharmaceutical actions +++

• The development of a terminology adapted to the drugs : Integration of

 the supplementary concepts (of MeSH thesaurus) which reference chemical substances  the international ATC (Anatomical, Therapeutic and Chemical) code  CAS (Chemical Abstract Service) code, EN (Enzyme Commission Number) code  trade (or brand or commercial) names for France and Denmark  the International Nonproprietary Names (INN),  the French CIP (Presentation Identifying Code), the French CIS (Specialty Identifying Code), the French UCD (Common Dispensation Unit) code,

Into the CISMeF backoffice, now multi-terminological

• Several health professionals could access the DIP using their own terminologies

Background

• All the previous terminologies and codes
• Integration to the CISMeF backoffice (secure access via https)
• Integration to the CISMeF terminology server (to help

CISMeF librarians to index DIP drug resources)

• Integration to the Doc’CISMeF search engine => multi-

terminology information retrieval

• Formal evaluation is mandatory (PhD S. Sakji)
• Integration to the MeSH (semi) automatic indexing

extractor => multi-terminology automatic indexing

• Pereira, S; Sakji, S; Névéol, A; Kergoulay, I; Kerdelhué, G; Serrot, E;

Joubert, M & Darmoni SJ. Abstract multi-terminology indexing for the assignment of MeSH descriptors. AMIA symp., 2009

Adaptation of several drug terminologies and codes

• Translation (in French) of over 8,000 MeSH

Supplementary Concepts (Additional Substance Names) + add-on 6,000 synonyms (e.g. chemical formula BrCs)

 French drugs and most toxic chemical substances for human (>50K€)

• Cooperation with Vidal company

 Danish brand names  Table of correspondence INN-ATC +++

• Accentuation of the ATC in French

 Cooperation with Memodata (10K€)

Results

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• The Drug Information Portal contains primarily search tools

inspired largely by the Doc'CISMeF search engine, but with some specificities focused on drugs.

 First prototype developped by the CISMeF team, in collaboration with the Vidal company  URL: http://doccismef.chu-rouen.fr/servlets/PIM  >25,000 resources in French, >1,000 in English (bilingual, most of them from EMEA)  Access restricted by ID/Pwd

• Potential commercial product for Vidal
• The Drug Information Portal was developed in four steps

Results

Step 1: creation of a metaterm “drug”

The CISMeF team has manually attached to the new metaterm “drugs”

 The MeSH descriptors in relation with the drug such as: “pharmacological actions”, “drug marketing authorization”, “drug contamination”.  The qualifiers which are used to index the documents concerning drugs namely: "drug action and chemical substances", "pharmacokinetics", "drug therapy" …  Creation of several resource types; in particular “information on the drug” and implicitly all the hierarchically lower resource types (e.g. vigilance note, drug evaluation, package leaflet, guideline to use properly a drug)

=> The regrouping of these terms on the level of the metaterm “drug” makes it possible to join together all the documents related to the drug.

Results

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Step 2: creation of the portal site

The DIP search tools contain a bilingual (French and English) simple and advanced search. Simple search can be done at a multi-terminology (or codes) level (e.g. by the brand name or the INN, ATC code, CAS, code, MeSH descriptor or SC, PA, resource type related to drugs. Advanced search allows a specific search by a combination of all the elements describing the drugs. => These various accesses are devoted to various users (pharmacists, pharmacologists, toxicologists…).

Results

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• The Drug Information Portal contains primarily search tools inspired largely by the

Doc'CISMeF search engine, but with some specificities focused on drugs.

• The Drug Information Portal was developed in four steps:
• Step 1: creation of a metaterm “drug”

The CISMeF team has manually attached to the new metaterm “drugs”

 The MeSH descriptors in relation with the drug such as: “pharmacological actions”, “drug marketing authorization”, “drug contamination”.  The qualifiers which are used to index the documents concerning drugs namely: "drug action and chemical substances", "pharmacokinetics", "drug therapy" …  The resource type “information on the drug” and implicitly all the hierarchically lower resource types.

=> The regrouping of these terms on the level of the metaterm “drug” makes it possible to join together all the documents related to the drug.

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Results

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Step 3: creation of the contextual links

Implementation of contextual links towards English speaking data and information bases in particular

 Drug Information Portal of the US National Library of Medicine (NLM), and  Entrez search tool of the NCBI, NLM, NIH in health sciences, which includes in particular Pub Med/MEDLINE and the NIH chemical databases.

Results

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Step 4: development of the “Google selection DIP”

specific Google drug search, named “Google DIP”, making it possible to carry out Google searches limited to a selection of health quality- controlled web sites relating to drugs and previously selected by the CISMeF team. These editor sites are the most important French institutional sites (like the High Health Authority or the French National Drug Safety Agency).

Discussion

• PSIP DIP = generic approach

 Could be reused at the European level  Possible interest for EMEA drug resources to be indexed using this multi-terminological approach, easily multi-lingual (e.g. ATC in Norwegian)

• In 2008, the US NLM set up the “NLM Drug Information

Portal”.

 This portal gives access to information concerning more than 12,000 drugs.  Search can also be made with the generic name or the trade name, MeSH descriptors, SC, PA  To our knowledge, research by CAS code or ATC code is not yet possible in this US Drug Information Portal.

Conclusion

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• In this paper, we have described a specific drug information portal,

with specific emphasis on its multi-terminological information retrieval

• Formal evaluation is mandatory to go further

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Results

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• The query results are presented as descriptive notes giving directly

access to information.

• Within each resource, a field named “substance” was defined making

it possible to gather and locate the respective substances, the MeSH descriptors linked to it as well as their contextual pharmacological actions and the hierarchical ATC classification.

Background

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 The ATC classification used to classify the drugs. The drugs are divided into various groups according to the organ or the system on which they act and/or their therapeutic and chemical

• characteristics. The ATC code has the general form LCCLLCC. Drugs are classified in five

groups at different levels:

The 1st level: anatomical group (1 alphabetical character). The 2nd level: principal therapeutic group (2 numerical characters). The 3rd level: therapeutic/pharmacological sub-group (1 alphabetical character). The 4th level: chemical/therapeutic/pharmacological sub-group (1 alphabetical character). The 5th level: sub-group for chemical substance: the individual active ingredient or the association of active ingredients (2 numerical characters) => the International Nonproprietary Name of the substance. Example: N

Nervous System (anatomical main group) N05 Psycholeptics (therapeutic subgroup) N05B Anxiolytics (pharmacological subgroup) N05BA Benzodiazepine derivatives (chemical subgroup) N05BA01 Diazepam (chemical substance)

Background

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• CAS (Chemical Abstract Service) code.
• The CAS registry number of polymeric chemicals, a biological sequence or an alloy

corresponds to its unique recording number in the Chemical Abstract Service database (CAS), a division of American Chemical Society (ACS).

• Within the MeSH thesaurus, the CAS codes are connected to the MeSH descriptors

and the MeSH Supplementary Concepts, which correspond to substances.

Background

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• The CIS includes 8 digits and is allocated to the pharmaceutical specialties being or

having made the subject of a drug approval.

• The CIP (code with 7 digits and recently with 13 digits) identifies the presentation
• f a pharmaceutical specialty.

=> A drug can be identified by several CIS numbers, which refer to a different dosage and/or a different dosage form for a specific drug. For the same CIS code, we can have several CIP codes according to the various existing presentations (size and/or conditioning).

• The UCD code characterizes the smallest unit used for the drugs dispensation in the

care establishments. The UCD code is formed by 7 digits established by the Club Inter Pharmaceutical, and published in the Official Journal.

T4.2. Drug Information Portal in Europe

• Access by several indexes

 Pharmaceutical actions  Drug names (brand or international)  Different codes (ATC, CAS, EC, CIS, CIP)  Resource types

• Same query with other Web sites

 Vidal drug database (not yet)  NIH Drug Information Portal (in English)  Entrez  Google CISMeF