Dr. Charlie Bavington GlycoMar Limited www.glycomar.com Exploiting - - PowerPoint PPT Presentation

• Dr. Charlie Bavington

GlycoMar Limited www.glycomar.com Exploiting marine glycobiology to advance human health

Company Profile Opportunities for utilisation of shellfish by- products Current products Potential / future products Some global opportunities Challenges

Marine Biotechnology company Established in February 2005 Located Oban, Scotland, at the European Center for Marine Biotechnology Focused on drug discovery through marine glycobiology Alliances with US / European Pharma and biotech companies

GlycoMar - Company Profile

Oban Oban

European Center for Marine Biotechnology

Marine organism sourcing and holding facilities Chemistry

Isolation of new products Purification of new products Characterisation of new products

Biology

Therapeutic applications Functional characterisation of new products

Products

Marine glycomolecules

Services

Anti-inflammatory screening

Fisheries by-product - raw materials opportunities

Process waste

Offal shell

Other species

By catch Fouling organisms (aquaculture)

Opportunity

Shellfish by-products represent an underutilised, abundant, rich and natural non- mammalian raw material

Seafish report SR537, 2001

Shellfish by-product - raw materials opportunities

Guy Robertson, Shellfish waste arisings in Scotland , 2004

74 26 % 100 51681 100 38220 100 13461 Totals 6 3029 5 1924 8 1105 Whelk 34 17405 38 14559 21 2846 Scallop 11 5771 12 4646 8 1126 Queens 12 6454 11 4239 16 2215 Crab 37 19021 34 12851 46 6169 Nephrop s % Tonnes % Tonnes % Tonnes Totals Shell Offal

Fisheries by-product - product opportunities Proteins / Amino Acids / Peptides

Fish meal, protein isolates, concentrates, hydrolyzates: specialty fertilizer, animal/pet feed, dietary food supplement, flavors, fermentation media Gelatin, collagen: industrial, dietary food supplement, food, cosmetic ingredient Enzymes, growth factors

Marine DNA: animal/pet feed, dietary food supplement, cosmetic ingredient

Fisheries by-product - product opportunities Oils

Fish oil / omega 3: industrial, animal/pet feed, dietary food supplement, food ingredients Phospholipids: animal/pet feed, dietary food supplement

Minerals

Fish bone and shell calcium: animal/pet feed, dietary food supplement, food ingredient

Fisheries by-product - product opportunities Chitin/Chitosan: specialty fertilizer, dietary food supplement, food ingredient, cosmetics, medical device Glycosaminoglycans: veterinary, dietary food supplement, human health Protamine: veterinary, human health Taurine: veterinary, human health Carotenoids/astazanthin: animal/pet feed, dietary food supplement Mucins: human health/pharmaceutical

Shellish by-products - product opportunities Shell

chitin/chitosan Calcium Carotenoids

Offal

Protein DNA Glycomolecules Carotenoids Omega 3 s

Novel by-products applications - potential markets

Nutraceutical

Additives Capsules

Cosmeceutical

Dermal augmentation

Pharmaceutical

Active pharmaceutical ingredients Human health Veterinary health

Examples of shellfish utilisation - Hemcon wound dressings

Novel Wound dressing

Chitosan based Chitosan produced from shrimp shell chitin Promotes rapid blood clotting

Chitin

Produced from crustacean shell, e.g. Primex in Iceland

Examples of shellfish utilisation - shrimp enzymes for research

Shrimp Alkaline phosphatase

Cold adapted Extracted from ice melt Life Science research market

Shrimp nuclease

Cold adapted Life Science research market

Shrimp alkaline phosphatase structure

Examples of shellfish utilisation - glycosaminoglycans for drug discovery

Glycosaminoglycans

Under development by GlycoMar Polysaccharide molecules present in all tissues Key role in cell-cell and cell-tissue interaction Potential therapeutic application in: Inflammation Immunology cancer metastasis viral infection stem cells

Marine glycosaminoglycans for drug discovery

Marine Glycosaminoglycans isolated from:

Scallop process by-product Whelk process by-product Mussels Nephrops by-product Fish skin

Properties

Chemically distinct Anti-inflammatory activity in vitro

Markets

Drug discovery companies Life Science research

Nutraceutical

Seeking licensing opportunities

Shellfish by-product utilisation - GlycoMar s strategy

Short term (1-3 years)

Product discovery - early income from reagent sales, contract research Process development - scalable production process

Medium term (3-6 years)

Nutraceutical - strategic alliance or licensing Development of immunoactive nutraceticals Development of dermal fillers Preclinical testing of drug candidates

Long term (6-10 years)

Clinical trials

Shellfish by-product utilisation - challenges

Cost of R&D

£ M s to bring pharmaceutical to market High risk investment

Lead-time for products

3-5 years Nutraceuticals/Cosmeceuticals 10-15 years Pharmaceuticals

Regulatory hurdles

ABP FDA / EMEA approval

Processing facilities

Shellfish by-products represent a valuable raw material Utilisation of shellfish by-products represents an

• pportunity for the shellfish industry

Utilisation of shellfish by products should focus on development of novel technologies Development of waste utilisation technologies requires investment

www.glycomar.com Exploiting marine glycobiology to advance human health