DISCLOSURE(S) CERA (Caisse dEpargne Rhne Alpes) Research Support: - - PowerPoint PPT Presentation

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DISCLOSURE(S) CERA (Caisse dEpargne Rhne Alpes) Research Support: - - PowerPoint PPT Presentation

May 04, 2023 274 likes •472 views

DISCLOSURE(S) CERA (Caisse dEpargne Rhne Alpes) Research Support: foundation for financing the 3 preparatory international seminars AXA Research Fund for covering all the costs of the field study Morbidity FR Herrmann 1 , K Andersen 2 , M

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SLIDE 1

DISCLOSURE(S)

Research Support: CERA (Caisse d’Epargne Rhône Alpes) foundation for financing the 3 preparatory international seminars AXA Research Fund for covering all the costs of the field study

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SLIDE 2

Morbidity

FR Herrmann1, K Andersen2, M Herr 3,4, M Parker 5, B Jeune2, Y Gondo6, 9, JM Robine7, 8, D Zekry1

  • 1. Internal medicine, rehabilitation and geriatrics, Geneva University Hospitals, THONEX, Switzerland.
  • 2. Danish Aging Research Center, Institute of Public Health, University of Southern, Odense, Denmark.
  • 3. UMR 1168, INSERM and Université Versailles St-Quentin-en-Yvelines, Villejuif & Montigny-le-Bretonneux, France
  • 4. Centre de Gérontologie, Hôpital Sainte-Périne, Assistance Publique-Hôpitaux de Paris, France
  • 5. Aging Research Center, Karolinska Institute, Stockholm, Sweden.
  • 6. Osaka University Graduate School of Human Sciences, Clinical Thanatology and Geriatric Behavioral Science, Suita, Osaka, Japan.
  • 7. Ecole Pratique des Hautes Etudes (EPHE), Paris, France.
  • 8. Université de Montpellier, Inserm, U1198, Montpellier, France.
  • 9. for the "Japanese 5-COOP team" : Yasu Arai; Yasuyuki Gondo; Hirose Nobuyoshi; Yasu Arai; Donald Craig

Willcox; Marina Kozono; Yukie Masui; Hiroki Inagaki, Various cities, Japan.

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SLIDE 3

Healthy centenarians?

  • Are centenarians people harbouring a subpopulation protected

against some diseases like cancer, dementia…?

  • ”Centenarians are the best examples of successful ageing as

they have escaped major age-related diseases and have reached the extreme end of human life”

  • Candore et al. 1997
  • ”Healthy centenarians do not exist, but autonomous do!”
  • Andersen-Ranberg et al. 2001
  • Scientific interest as a human model of relative resistance to

dementia?

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SLIDE 4

Pooled heart disease

Heart attack, heart failure, atrial fibrillation, HTA

10 20 30 40 50 60 70 80 90 JP FR CH SE DK Percent nt Females Males

Hy Hypertension 28% 28% FR FR  55% 55% JP JP Myocardia ial infarctio ion 9% 9% DK DK  56% 56% FR FR

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SLIDE 5

Stroke

5 10 15 20 25 JP FR CH SE DK Per ercent Females Males

St Stroke 10% 10% FR FR an and DK DK  19% 19% SE SE

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SLIDE 6

Diabetes

2 4 6 8 10 12 JP JP FR FR CH CH SE SE DK DK Per ercent Females Males

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SLIDE 7

COPD

2 4 6 8 10 12 FR CH SE DK JP Percent Females Males

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SLIDE 8

Falls within the last 6 months

10 20 30 40 50 60 JP FR CH SE DK Percent Females Males

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SLIDE 9

Malignant cancer

5 10 15 20 25 30 JP FR CH SE DK Percent Females Males

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SLIDE 10

Multimorbidity

p = 0.00010

0,0 10,0 20,0 30,0 40,0 50,0 60,0 70,0 JP FR CH SE DK

0-1 2-4 5+

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SLIDE 11

Centenarians living in institution (%)

47,6 44,3 74,7 42,3 45,8 47,6

JP FR CH SE DK Total

N 346 212 170 274 251 1253

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SLIDE 12

Results

Diseases and conditions are common in centenarians

  • Falls
  • Symptoms
  • Cardio-vascular diseases
  • Multimorbidity
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SLIDE 13

Results

  • More common in FRANCE and SWITZERLAND
  • Heart diseases
  • Roughly similar across countries
  • Stroke
  • COPD
  • Diabetes
  • Symptoms
  • Falls
  • Multimorbidity
  • High 5+ diseases in CH

Centenarians are not healthy in terms of disease

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SLIDE 14

Multivariate logistic regression

  • Adjusting for sex, education, nursing home residency, ADL limitations,

and interview mode

  • Japan = reference country
  • HYPERTENSION significantly lower in France, Sweden and Denmark, and

borderline significant in Switzerland.

  • CARDIO-VASCULAR DISEASES significantly higher in France (OR 4.0),

Switzerland (5.0), Sweden (1.6) and Denmark (1.5)

  • FALL within the last 6 months significantly higher in all countries but

small effect sizes (OR: 1.8-2.4).

  • MULTIMORBIDITY (2+ diseases), DIABETES no variation across countries.
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SLIDE 15

Explaining differences and similarites

  • True differences?
  • True similarities?
  • Methodological differences?
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SLIDE 16

Methodology

  • Ex-ante harmonized questionnaire
  • But interviewers have different backgrounds

N J F CH S DK All Anthropologist 1 Sociologist 1 Psychologist 3 5 Nurse 3 Physician 5 Lay interviewer 1 1 9 Graduate students 5 Survey agency interviewer 15 2 5 9 3 34

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SLIDE 17

Response modes

0,0 10,0 20,0 30,0 40,0 50,0 60,0 70,0 80,0 90,0 100,0 J F CH S DK All Direct interviews Mixed interviews Proxy interviews Missing

Direct interview

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SLIDE 18

Response types

0,0 10,0 20,0 30,0 40,0 50,0 60,0 70,0 80,0 90,0 100,0 J F CH S DK All Visit Phone Mailing only

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SLIDE 19

Conclusion

  • Variation in morbidity and symptoms between the

5 countries

  • Some of the variations are likely caused by

differences in methodology

  • However, the 5-COOP study is the first cross-

national study on centenarians using an ex-ante harmonized survey questionnaire

  • Further studies emphasizing harmonization of

methodology are needed