DEVELOPING NOVEL, FIRST-IN-CLASS CARDIOVASCULAR DRUGS Corporate - - PowerPoint PPT Presentation

developing novel first in class cardiovascular drugs
SMART_READER_LITE
LIVE PREVIEW

DEVELOPING NOVEL, FIRST-IN-CLASS CARDIOVASCULAR DRUGS Corporate - - PowerPoint PPT Presentation

DEVELOPING NOVEL, FIRST-IN-CLASS CARDIOVASCULAR DRUGS Corporate Presentation April 2019 Disclaimer This presentation and the information contained herein does not constitute or form part of, and should not be construed as, an offer or


slide-1
SLIDE 1

DEVELOPING NOVEL, FIRST-IN-CLASS CARDIOVASCULAR DRUGS

Corporate Presentation April 2019

slide-2
SLIDE 2

www.quantum-genomics.com

This presentation and the information contained herein does not constitute or form part of, and should not be construed as, an

  • ffer or invitation to sell or subscribe for, or a solicitation of any offer or invitation to acquire, dispose of or subscribe for, securities
  • f Quantum Genomics S.A. (the « Company») in any country where such offer, invitation or subscription would be prohibited by
  • law. The publication of this presentation in certain countries may violate applicable regulations.

The new securities referred to herein have not been, and will not be, registered under the United States Securities Act of 1933, as amended (the « Securities Act ») or any securities laws of any state within the US and may not be offered or sold, directly or indirectly, in or into the US, except pursuant to an available exemption from, or a transaction not subject to, the registration requirements of the Securities Act and in compliance with any applicable state securities laws of the US. Any offering of the Shares to be made in the US will be made only to a limited number of persons who: (i) are reasonably believed to be qualified institutional buyers (as defined in Rule 144A under the Securities Act) and/or institutional accredited investors (as defined in Regulation D under the Securities Act), and (ii) have executed and returned an investor issuance agreement, in designated form, to the Company. With respect to the member states of the European Economic Area which have implemented the Directive 2003/71/EC of the European Parliament and the Council of November 4, 2003, as amended in particular by Directive 2010/73/EC of the European Parliament and of the Council of November 24, 2010 (the «Prospectus Directive»), no action has been undertaken or will be undertaken to make an offer to the public of the securities referred to herein requiring a publication of a prospectus in any relevant member state. As a result, the securities may not and will not be offered in any relevant member state, or under any

  • ther circumstances which do not require the publication by the Company of a prospectus pursuant to Article 3 of the

Prospectus Directive and/or to applicable regulations of that relevant member state. In accordance with Article 211-3 of the General Regulation of the Autorité des marchés financiers, no prospectus has been prepared nor will be disclosed by the Company or filed with the Autorité des marchés financiers in relation to the issuance of the new securities referred to herein. This presentation contains certain forward-looking statements. No guarantee can be given as to any of the events anticipated by the forward looking statements, which are subject to inherent risks, including those described the Prospectus registered with the Autorité des marchés financiers under number 15-036 on January 26, 2015, and the rapport financier semestriel disclosed by the Company on October 13, 2016, changes in economic conditions, the financial markets or the markets in which the Company operates.

Disclaimer

2

slide-3
SLIDE 3

www.quantum-genomics.com

Lionel Ségard – Founder & Chairman

  • Former CEO of Inserm-Transfert, subsidiary of INSERM (French National Institute for Health and Medical Research)
  • Founder and former president of Inserm Transfert Initiative (seed fund dedicated to young, innovative healthcare companies)
  • Founder of the Strategic Council for Innovation (Secretary General in 2003-2005), whose goal is to boost French efforts in

research and high technologies and included key figures from France's science, industry and financial community

  • Biochemist by training (University of South Paris - Orsay)

Jean-Philippe Milon, PhD – Chief Executive Officer

  • Several management positions at Bayer Healthcare, member of the Worldwide Executive Committee

as Head of WW Business Development, Licensing, Mergers & Acquisitions

  • Previously head of the cardiovascular business at Sandoz
  • More than 25 years of experience in healthcare and pharmaceuticals

Marc Karako – Chief Financial Officer

  • Previously Executive Vice President & Chief Financial Officer of Carlson Wagonlit Travel
  • Former Chief Financial and Legal Officer of Vallourec and former Vice President Finance at Thomson Multimedia
  • 10 years at IBM in various financial management positions
  • Master of engineering (Ecole des Ponts ParisTech) and MBA from the University of Chicago

Bruno Besse – Chief Medical Officer

  • More than 20 years experience in the pharmaceutical industry
  • Held several R&D and Medical Affairs positions in big pharma companies (Aventis, BMS) in cardiology and thrombosis as well as in a start-up

company (medical device)

  • MD, cardiologist and graduated in Biostatistics

Fabrice Balavoine – Vice President Research & Development

  • 20 years of experience in drug discovery and development
  • Held several Executive and R&D positions in biotech companies (Galactis Pharma, Sepal Pharma, Anceris, Cerep)
  • Developed several clinical-stage drug candidates (new chemical entities, peptides and recombinant proteins) across various therapeutic areas
  • Ph.D. in Organic Chemistry from the University Paris-Sud, M.Sc. from Ecole Supérieure de Physique et de Chimie Industrielle of Paris (ESPCI) and

Executive MBA from the ESSEC & Mannheim Business School

Experienced Management Team

3

slide-4
SLIDE 4

www.quantum-genomics.com

Professor Mark Caulfield

  • Co-director of William Harvey Research Institute, Barts and

The London School of Medicine and Dentistry, Queen Mary University of London (UK)

  • Director of the NIHR Biomedical Research Unit in

Cardiovascular Disease at Barts (UK)

  • Member of the UK Academy of Medical Sciences

Professor Alexandre Persu

  • Head of the Hypertension Clinic, Cardiology Department,

Cliniques Universitaires Saint-Luc, Catholic University of Louvain, Belgium

  • Member of the International and European Society of

Hypertension

Scientific & Clinical Advisory Board

Henry Black, MD

  • Former President of the American Society of Hypertension
  • Led several landmark clinical trials including the Systolic

Hypertension in the Elderly Program

  • Member of the Department of Cardiology at the New York

University School of Medicine

Howard Dittrich, MD

  • Adjunct Professor of Medicine at the University of Iowa

Carver College of Medicine

  • Chairman of the board of Directors of the F. M. Abboud

Cardiovascular Research Center (University of Iowa)

  • Cardiologist with >20 years of experience in

cardiovascular research and clinical development

Keith Ferdinand, MD

  • Professor of Medicine at the Tulane University School of

Medicine (New Orleans)

  • Hypertension specialist certified by the American Society of

Hypertension

  • Conducted numerous cardiovascular disease / hypertension

clinical trials especially in racial and ethnic minorities 4

Toshiro Fujita, MD

  • Professor of the Department of Clinical Epigenetics, RCAST,

The University of Tokyo

  • Former President of the Japanese Society of Hypertension
  • Vice-President of the International Society of Hypertension

Frans Leenen, MD

  • Director of the Hypertension program at the University of

Ottawa Heart Institute

  • Professor of Medicine and Pharmacology at the University
  • f Ottawa
  • His research focuses on the role of brain mechanisms in

hypertension and congestive heart failure

slide-5
SLIDE 5

www.quantum-genomics.com

Company Highlights

Targeting highly unmet medical needs in resistant hypertension and heart failure Hypertension clinical program with firibastat

Announced on November 12, 2018, excellent results for U.S. phase IIb “NEW-HOPE”. Launch of a pivotal phase III study in Q2 2019. Results expected in H2 2021.

Heart failure clinical program with firibastat

Launch of phase IIb “QUORUM”, proof of concept study in Europe and US, in Q4 2018. Results expected in H2 2020.

Broad intellectual property portfolio

multiple patent families granted or filed, up to 2033.

Novel therapeutic class to treat cardiovascular diseases:

Brain Aminopeptidase A Inhibitors (BAPAIs) provide antihypertensive effects and cardioprotection. Generic name firibastat for QGC001 approved by the World Health Organization.

Experienced management and Scientific/Clinical Advisory Boards

composed of top experts in their fields.

5

slide-6
SLIDE 6

www.quantum-genomics.com

Development Pipeline

Four R&D Programs based on BAPAI Platform

CONGESTIVE HEART FAILURE HYPERTENSION

First-in-class

Prevention and treatment of congestive heart failure

Firibastat

Proof of efficacy (single dose) in hypertensive rats Regulatory Preclinical results Pharmacokinetics and toxicology (rats and dogs)

First-in-class

Treatment of hypertension as monotherapy

Firibastat

Combination

Treatment of hypertension in combination

QGC011

Best-in-class

Optimized treatment

  • f hypertension

as monotherapy

QGC006

Identification of active compounds Preclinical studies Clinical studies Phase I Clinical studies Phase IIa Clinical studies Phase IIb Clinical studies Phase III New drug approval (NDA) Commercia- lisation

Proof of efficacy repeated doses (post infarction rat and dog models) and start of Phase IIb Quantum Genomics Partner

Typically, identification and preclinical phases last 2-3 years, a phase I 1-2 years, a Phase IIa 1-2 years , a Phase IIb 1-2 years, a Phase III 2-3 years and new drug approval and commercialization 2-3 years.

Tolerance, safety and efficacy in hypertensive patients in Phase IIb 6 Nov 12, 2018: Results of U.S Phase IIb trial Q4’18: Initiation of Phase IIb in the EU and U.S.

slide-7
SLIDE 7

www.quantum-genomics.com

Market Data

$40 billion

global anti-hypertensive drug market in 2013 (1)

Sources : (1)The pharmaletter (2014) (2) Heidenreich et al, Circulation Heart Failure (2013). (3) WHO (World Health Organization) - A global brief on hypertension, Silent killer, global public health crisis (2013) (4) National Hospital Discharge Survey, CDC/NCHS and NHLBI,

23 million

people suffer from heart failure worldwide

50% Survival Rate

within 5 years of diagnosis, worse survival rate than most cancers(4)

$39 billion

global heart failure drugs market estimate for 2015 (2)

9.4 million

deaths worldwide every year due to complications of high blood pressure (3)

30% poorly controlled

mostly patients with salt-dependent hypertension. Half of them (15%, 150+ million) have resistant hypertension.

HIGH BLOOD PRESSURE HEART FAILURE

1/3 people worldwide die due to cardiovascular diseases Main cause of death with 17 million deaths per year

1/3 of adults

have high blood pressure. The proportion increases to one-in-two for people above age 50 (1)

7

Quantum is targeting areas of high unmet need

slide-8
SLIDE 8

www.quantum-genomics.com

Quantum Genomics is Targeting a Large, Untapped Hypertension Sub-population

8

Current blockbuster hypertension drugs only address 70% of the hypertension market

Blockbuster (I.N.N.) Company Diovan (valsartan) Micardis (telmisartan) Benicar, Olmetec (olmesartan) Avapro, Aprovel (irbesartan) Blopress (candesartan)

Quantum Genomics strategy is to develop Firibastat in resistant hypertension

  • Resistant hypertension is a high unmet

need (common, leading to high CV morbidity and mortality)

  • Firibastat’s MOA(1) makes it effective

whatever the hormone profile (salt- dependent or not)

  • Salt-dependent hypertension is common

in elderly, Asian, African American and Hispanic populations

  • ACE-I(2) and ARBs(3) have poor efficacy in

salt-dependent hypertension which is

  • ften resistant

30% of the hypertensive population is poorly controlled and 15% have resistant hypertension (i.e. uncontrolled despite 3

therapeutic classes including a diuretic)

(1) Mode of action (2) Angiotensin-converting-enzyme inhibitor (ACE-I) (3) Angiotensin-receptor blocker (ARB)

slide-9
SLIDE 9

www.quantum-genomics.com

Other Treatments in Development for Resistant Hypertension Peak sales estimates

9

Company Product Mechanism of Action Phase Indication Upcoming Catalyst Aprocitentan Endothelin A & B receptor antagonist Phase III Treatment-Resistant Hypertension Announced enrollment of first patient in PRECISION trial (June ’18) LHW090 Neprilysin inhibitor Phase II Treatment-Resistant Hypertension Initiation of Phase IIb study (YE'18) IONIS-AGT-LRx Angiotensinogen antisense Phase I/II Treatment-Resistant Hypertension Phase I/II Topline Results (2H'18) BAY sGCstim sGC modulator Pre-clinical Treatment-Resistant Hypertension No update

Equity research estimates of annual peak sales in resistant hypertension: For Quantum Genomics, Edison: 2.1 Bio $ For Idorsia, Morgan Stanley and Deutsche Bank: 2.3 Bio $

slide-10
SLIDE 10

BAPAI, a novel therapeutic class

1

slide-11
SLIDE 11

www.quantum-genomics.com

Brain Aminopeptidase A Inhibitors (BAPAIs)

Quantum Genomics, the BAPAI company, is developing first-in-class treatments targeting a new pharmacological pathway in the brain

Hypertension Heart failure Other diseases

Catherine Llorens-Cortes, Ph.D. PhD in Neurobiology, Director of the Central Neuropeptides and cardio-vascular hydro- regulation research team – College de France CIRB-CNRS UMR U1050 7241/INSERM

Novel Therapeutic Approach to Treat Hypertension and Associated Cardiovascular Diseases

BAPAI: Brain AminoPeptidase A Inhibitors

More than 20 years of leading European academic research

11

slide-12
SLIDE 12

www.quantum-genomics.com

BAPAI Pathway Mechanics

A triple mechanism of action with a single drug

Increase of the diuresis (urinary elimination) Inhibition of Aminopeptidase A (APA) prevents conversion of Angiotensin II into Angiotensin III Innovative novel drugs target a new central pharmacological pathway leading to both antihypertensive effects and cardioprotection Lowering vascular resistance Controlling heart rate

Angiotensin II

BAPAI

Angiotensin III

Vasopressin release Sympathetic nerve activity Baroreflex

Mechanism of action described in several peer-reviewed academic publications *:

Bodineau & al – Hypertension – 2008 Marc & al – ProgNeuroscience – 2011 Marc & al – Hypertension – 2012 * Firibastat (QGC001) also known as RB150

12

Reduction in Angiotensin III via APA inhibition results in :

slide-13
SLIDE 13

Firibastat for the treatment of hypertension

2

slide-14
SLIDE 14

www.quantum-genomics.com

14

Phase I and IIa studies

159 subjects were enrolled and 129 received QGC001

Phase Ia • 2012

Randomized, double-blind, placebo controlled study

  • f single ascending doses in 80 healthy volunteers

Positive: overall safety and tolerability

  • f firibastat up to 2g

Phase Ib • 2013

Randomized, double-blind, placebo controlled study

  • f multiple ascending doses in 44 healthy volunteers

Positive: overall safety and tolerability

  • f firibastat up to 750mg twice a day

and no food interaction

Phase IIa • Q1 2015

Initiation of a phase IIa in 34 moderate hypertensive patients

Positive: firibastat led to a decrease in ambulatory (-2,7 mmHg) and office blood pressure (-4,7 mmHg) as compared to placebo and was safe Blood pressure decrease was higher in patients with a higher baseline hypertension

slide-15
SLIDE 15

www.quantum-genomics.com

Q4 2017: Start of NEW-HOPE Phase IIb in hypertension leading to Phase III if successful trial

NEW-HOPE (Novel Evaluation With QGC001 in Hypertensive Overweight Patients of Multiple Ethnic Origins)

Firibastat, Phase IIb Clinical Study Design in Hypertension

Preclinical studies Phase I Phase IIa Phase IIb Phase III New drug approval (NDA) Commercialisa tion

Trial subjects: 250 patients with primary hypertension, overweight

  • r obese, at least 50% of African Americans and Hispanics

Trial sites: 38 centres in the United States End of recruitments was announced on September 6, 2018, more than 6 months ahead of initial schedule Excellent results were presented on November 10, 2018, at the late- breaking science session

  • f

the American Heart Association meeting in Chicago

Clinical studies

15

First-in-class

Treatment of hypertension as monotherapy

Firibastat

  • Professor of Medicine at the Tulane

University School of Medicine (New Orleans)

  • Hypertension

specialist certified by the American Society of Hypertension

Professor Keith Ferdinand, MD

Tolerance, safety and efficacy in hypertensive patients in Phase II

slide-16
SLIDE 16

www.quantum-genomics.com

Phase II

NEW-HOPE Study

Study design Multicenter, Open-Label, US trial Treatment period: 8 weeks Primary Endpoint : change from baseline in automated office systolic blood pressure (SPRINT-like) Secondary Endpoints : ABPM, safety, PK

BID: twice daily (bis in die); QD: once a daily (quaque die) HCTZ: Hydrochlorothiazide

2 weeks 2 weeks 2 weeks 4 weeks

Run-in (no treatment) Firibastat 250mg BID Firibastat 250mg BID Firibastat 500mg BID If AOBP >140/90 Firibastat 250mg BID Firibastat 500mg BID Firibastat 500mg BID + 25mg HCTZ QD If AOBP >160/110

D56 End of treatment period D28 D14 Baseline D0 Screening

16 16

Study population 256 high-risk, difficult-to-treat hypertensive patients Age: 58.3 years old 100 % overweight – including 65 % obese 28 % type-2 diabetes 53 % minorities patients – including 38 % blacks Baseline AOBP: 154/91 mmHg

BP: Blood Pressure; AOBP: Automated Office Blood Pressure ABPM: Ambulatory Blood Pressure Monitoring Clinicaltrials.gov : NCT03198793

slide-17
SLIDE 17

www.quantum-genomics.com

Change at day 56 P value* Systolic AOBP

  • 9.7 mmHg

<0.0001 Diastolic AOBP -4.3 mmHg <0.0001

153.9±7.2 .2 144.3*±14.2 .2

7 14 14 28 28 56 56

N=254 54

*ITT population-LOCF LOCF: Last observation carried forward 95% confidence interval

N=254 54

Firibastat Phase IIb clinical study

Primary Endpoint: change after week 8 in systolic AOBP

Multivariate analysis: baseline blood pressure is the only predictive factor (the higher the initial BP, the larger the effect)

17

slide-18
SLIDE 18

www.quantum-genomics.com

Black N = 96 Non-Black N = 158 Age, mean (SD), y 57.2 (8.5) 59.0 (10.6) BMI, mean (SD), kg/m² 34.3 (5.1) 32.2 (5.1) Systolic AOBP, mean (SD), mmHg 153.8 (7.1) 154.0 (7.3) Change in systolic AOBP (mmHg)

  • 10.5 (14.7)

p<0.0001

  • 9.1 (14.2)

p<0.0001

Firibastat Phase IIb clinical study

Effectiveness in subgroups of patients Obese N = 166 Non-Obese N = 88 Systolic AOBP, mean (SD), mmHg 153.8 (7.2) 154.3 (7.3) Change in systolic AOBP (mmHg)

  • 10.4 (14.6)

p<0.0001

  • 8.3 (13.9)

p<0.0001

In addition, Firibastat had a good safety profile.

18

slide-19
SLIDE 19

www.quantum-genomics.com

Firibastat

Consistency between experimental and clinical (human) data

19

  • 35
  • 30
  • 25
  • 20
  • 15
  • 10
  • 5

normotensive rat SHR DOCA-Salt

Rat

Placebo QGC001

  • 9
  • 7
  • 5
  • 3
  • 1

1

normotensive volunteers unselected hypertensive High-risk, difficult to treat hypertensive

Human

Placebo firibastat Change in blood pressure (mmHg) Change in office blood pressure (mmHg)

slide-20
SLIDE 20

Firibastat for the treatment of heart failure

3

slide-21
SLIDE 21

www.quantum-genomics.com

Based on excellent efficacy data in animals and good safety profile in pilot phase IIa, initiation in Q4 2018 of a Phase IIb trial (QUORUM): efficacy and safety in patients with reduced ejection fraction after acute myocardial infarction, head to head versus reference therapy (ACE-i)

Firibastat, Phase IIb in Congestive Heart Failure

21

QUORUM Study Design

  • Lead expert in acute coronary syndrome, acute myocardial infarction
  • Chairman of the ESC guidelines committee for acute coronary syndrome
  • Head of the cardiology department at Hôpital Pitié-Salpétrière, Paris V University.

Other steering committee members: Pr John Alexander (Duke University, USA), Pr Leonardo Bolognese (Toscana University, Italy), Pr Angel Cequier-Fillat (Bellvitge University, Spain), Pr Harald Darius (Vivantes Berlin, Germany), Pr Scott Solomon (Harvard University, USA) Principal investigator: Professor Gilles Montalescot Trial subjects: 294 patients with reduced ejection fraction following acute anterior myocardial infarction Randomized, double-blind, active-controlled, 3 parallel groups (Firibastat 100mg BID, Firibastat 500mg BID, Ramipril 5mg BID), 3 month-treatment period Primary endpoint: change from baseline in left ventricular ejection fraction (Cardiac MRI) Trial sites: approximately 38 hospitals in USA, France, Germany, UK, Spain, Czech Republic, Hungary and Slovakia Results: H2 2020

slide-22
SLIDE 22

Efficient organisation and strong assets

4

slide-23
SLIDE 23

www.quantum-genomics.com

Patent family 1

(granted)

Patent family 2

(granted)

Patent family 3

(granted)

Patent family 4

(filed)

Patent family 5

(filed)

Patent family 6

(filed)

Applicants

(exclusive WW license) (exclusive WW license) (exclusive WW license)

Area of invention Concept of BAPAI to treat hypertension (active ingredient patent) QGC001 for the treatment of hypertension and related diseases QGC006 for the treatment of hypertension and related diseases QGC001 trihydrate form (current product) for the treatment of hypertension and related diseases QGC011 for the treatment of hypertension and related diseases QGC001 L-lysine form for the treatment of hypertension and related diseases Status

Granted Granted Granted

International application

Granted

International application

Granted

International application

Granted

Expiration date

14/01/2019 16/07/2023 * 06/08/2024 ** 07/11/2031* 21/12/2032 * 10/22/2033 *

Patents operated by Quantum Genomics provide secure protection for firibastat up to 2031 (plus possible 5 years extension)

* Potential patent protection extention for 5 years ** Data exclusivity if the patent expires before the date of market availability ( 10 years in France, 5 years in the USA)

23

Strong and Broad Intellectual Property Composition of matter patents

slide-24
SLIDE 24

www.quantum-genomics.com

Financials

Simplified Income Statements and Balance Sheet

Audited data in K€ French GAAP FY 2018 FY 2017 Income 71.3 25.7 Personnel expenses (2,402.6) (2,456.0) Other operating expenses (11,266.8) (7,8612.6) OPERATING RESULT (13,598.1) (10,291.9) FINANCIAL RESULT 104,0 (63.3) EARNINGS BEFORE TAXES (13,448.5) (10,631.2) RESEARCH TAX CREDIT 1,458.4 1,150.0 NET INCOME (11,990.1) (9,481.2) Audited data in K€ French GAAP 12/31/2018 Fixed assets 625.5 Inventory/receivables 2,443.1 Cash 14,797.2 Prepaid expenses 614.6 TOTAL ASSETS 18,480,4 Shareholders equity 11,867.7 Other equity (conditional advance) 1,030.0 Provisions 259.7 Financial debt 0.0 Current liabilities 5,323.0 TOTAL EQUITY AND LIABILITIES 18,480.4

24

Remaining equity financing facility of 9.1 M€, structured and backed by Kepler Cheuvreux

slide-25
SLIDE 25

www.quantum-genomics.com

Financials

Optimized Cash Management

Data in K€ - audited FY 2018 FY 2017 FY 2016 Net income corrected for non-cash effects (11,828) (9,208) (5,213) Change in net working capital 926.0 1,231 (318) Investments (231) 146 (208) FREE CASH FLOW (11,132) (7,831) (5,736) Capital increase (net) 15,071 7,733 7,744 Borrowings and shareholders’ loans Debt repayment Other elements (mainly Bpifrance loans) (231) (10) 540 FINANCINGS 14,841 7,723 8,284 Change in cash 3,708 (108) 2,545 CASH (END OF PERIOD) 14,797 11,089 11,197

€ 48.6 million

Cash expenses (primarily R&D)

Cash from inception

January 2006 – December 2018

€ 56.0 million

Equity financing

€ 2.4 million

Subsidies/loans from Bpifrance (Public Innovation Bank) and ANR (National Research Agency)

€ 5.0 million

Research Tax Credits (RTC)

Joint capital increases USA & Europe in 2016 and 2017

25

slide-26
SLIDE 26

www.quantum-genomics.com

Financials

Shareholding & Stock Exchange Information

Stock market data

Listed on Euronext Growth Paris since April 10, 2014. ISIN : FR0011648971; ticker: ALQGC. Trading in the U.S. on OTCQX; symbol: QNNTF. Market capitalisation: 87 M€ as of April 5, 2019.

Potential dilution

Up to 2,180,006 new shares could be issued if all existing common share purchase warrants were to be exercised, which represents 11.6% potential dilution. Total number of shares as of March 31st, 2019: 16,618,985 Capital breakdown as of January 31st, 2019:

26

Retail investors

74.9%

Tethys

6.1%

Management

7.8%

Institutional funds

11.2%

slide-27
SLIDE 27

A strategy focused on rapid value creation

5

slide-28
SLIDE 28

www.quantum-genomics.com

Representative Transactions

Acquirer Developer Indication Status Terms

Resistant hypertension Phase II Exercise of license option = Milestone of $230 million, plus Royalties from 20% to 35% according to sales Heart Failure Phase II Acquisition up to $2 billion+, with $300 M upfront and potentially a further $1.775 billion based on development, regulatory and sales related milestones Cardiovascular Phase I Upfront payment + up to €120 million license fees and milestone payments; Servier to continue development of XEN-D0103; Owns commercial rights ex US and Japan

Business Development Strategy

Targeting Partnerships with Big Pharma

Goal

Building an alliance with a pharmaceutical company to develop the BAPAI platform

Upfront/Milestones

Financing clinical and regulatory trials starting from the signature of the license

Royalties

▪ The partner will be in charge

  • f marketing and sales activities

▪ Starting sales ASAP after New Drug Approval ▪ Quantum Genomics will receive royalties on sales

28

slide-29
SLIDE 29

www.quantum-genomics.com

Appendix 1

29

Mode of action of major anti-hypertensive drugs

slide-30
SLIDE 30

www.quantum-genomics.com

Appendix 2

QGC011: Combination Program

Target discovery Identification

  • f active

compounds Preclinical studies Clinical studies Phase I

Combo BAPAI / IEC

Treatment of hypertension in combination with other antihypertensives/ combination therapy for reduced dosing and reduction of side effects

QGC011

An alternative product to current marketed antihypertensive drugs

Therapeutic solution for patients resistant to existing treatments Synergistic action that allows for dosage reduction and minimized side-effects

Preclinical results demonstrate high interest in combination with the Angiotensin Converting Enzyme inhibitor, Enalapril (Renitec/Vasotec) Synergy of action should improve the control of BP in hypertensive patients

30

slide-31
SLIDE 31

www.quantum-genomics.com

Firibastat reduces the renal sympathetic nerve hyperactivity and improves left ventricular dysfunction observed in rat post myocardial infarction better than losartan Sham MI size (%) Vehicle Losartan Firibastat Renal sympathetic nerve activity (%) EF (%) LVPSP (mmHg) LVEDP (mmHg) dP/dtmax (mmHg/s)

  • 25 ± 1

24 ± 2 24 ± 1 7259 ± 293 17 ± 2 34 ± 2 23 ± 2 20 ± 2 92 ± 2 126 ± 2 3 ± 1 8076 ± 145 66 ± 3 120 ± 1 6116 ± 141 16 ± 2 63 ± 3 6740 ± 63 9 ± 1 118 ± 3 124 ± 2 76 ± 2 9 ± 1 Left ventricular function: MI

Adapted from Huang et al, Cardiovasc Res 2013

Appendix 3

QGC101: BAPAI Rationale for Treatment of Heart Failure

31

slide-32
SLIDE 32

QUANTUM GENOMICS SA

Tour Montparnasse 33 avenue du Maine 75015 PARIS FRANCE T : + 33 (0)1.85.34.77.70 marc.karako@quantum-genomics.com