DEVELOPING NOVEL, FIRST-IN-CLASS CARDIOVASCULAR DRUGS Corporate - - PowerPoint PPT Presentation
DEVELOPING NOVEL, FIRST-IN-CLASS CARDIOVASCULAR DRUGS Corporate - - PowerPoint PPT Presentation
DEVELOPING NOVEL, FIRST-IN-CLASS CARDIOVASCULAR DRUGS Corporate Presentation April 2019 Disclaimer This presentation and the information contained herein does not constitute or form part of, and should not be construed as, an offer or
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This presentation and the information contained herein does not constitute or form part of, and should not be construed as, an
- ffer or invitation to sell or subscribe for, or a solicitation of any offer or invitation to acquire, dispose of or subscribe for, securities
- f Quantum Genomics S.A. (the « Company») in any country where such offer, invitation or subscription would be prohibited by
- law. The publication of this presentation in certain countries may violate applicable regulations.
The new securities referred to herein have not been, and will not be, registered under the United States Securities Act of 1933, as amended (the « Securities Act ») or any securities laws of any state within the US and may not be offered or sold, directly or indirectly, in or into the US, except pursuant to an available exemption from, or a transaction not subject to, the registration requirements of the Securities Act and in compliance with any applicable state securities laws of the US. Any offering of the Shares to be made in the US will be made only to a limited number of persons who: (i) are reasonably believed to be qualified institutional buyers (as defined in Rule 144A under the Securities Act) and/or institutional accredited investors (as defined in Regulation D under the Securities Act), and (ii) have executed and returned an investor issuance agreement, in designated form, to the Company. With respect to the member states of the European Economic Area which have implemented the Directive 2003/71/EC of the European Parliament and the Council of November 4, 2003, as amended in particular by Directive 2010/73/EC of the European Parliament and of the Council of November 24, 2010 (the «Prospectus Directive»), no action has been undertaken or will be undertaken to make an offer to the public of the securities referred to herein requiring a publication of a prospectus in any relevant member state. As a result, the securities may not and will not be offered in any relevant member state, or under any
- ther circumstances which do not require the publication by the Company of a prospectus pursuant to Article 3 of the
Prospectus Directive and/or to applicable regulations of that relevant member state. In accordance with Article 211-3 of the General Regulation of the Autorité des marchés financiers, no prospectus has been prepared nor will be disclosed by the Company or filed with the Autorité des marchés financiers in relation to the issuance of the new securities referred to herein. This presentation contains certain forward-looking statements. No guarantee can be given as to any of the events anticipated by the forward looking statements, which are subject to inherent risks, including those described the Prospectus registered with the Autorité des marchés financiers under number 15-036 on January 26, 2015, and the rapport financier semestriel disclosed by the Company on October 13, 2016, changes in economic conditions, the financial markets or the markets in which the Company operates.
Disclaimer
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Lionel Ségard – Founder & Chairman
- Former CEO of Inserm-Transfert, subsidiary of INSERM (French National Institute for Health and Medical Research)
- Founder and former president of Inserm Transfert Initiative (seed fund dedicated to young, innovative healthcare companies)
- Founder of the Strategic Council for Innovation (Secretary General in 2003-2005), whose goal is to boost French efforts in
research and high technologies and included key figures from France's science, industry and financial community
- Biochemist by training (University of South Paris - Orsay)
Jean-Philippe Milon, PhD – Chief Executive Officer
- Several management positions at Bayer Healthcare, member of the Worldwide Executive Committee
as Head of WW Business Development, Licensing, Mergers & Acquisitions
- Previously head of the cardiovascular business at Sandoz
- More than 25 years of experience in healthcare and pharmaceuticals
Marc Karako – Chief Financial Officer
- Previously Executive Vice President & Chief Financial Officer of Carlson Wagonlit Travel
- Former Chief Financial and Legal Officer of Vallourec and former Vice President Finance at Thomson Multimedia
- 10 years at IBM in various financial management positions
- Master of engineering (Ecole des Ponts ParisTech) and MBA from the University of Chicago
Bruno Besse – Chief Medical Officer
- More than 20 years experience in the pharmaceutical industry
- Held several R&D and Medical Affairs positions in big pharma companies (Aventis, BMS) in cardiology and thrombosis as well as in a start-up
company (medical device)
- MD, cardiologist and graduated in Biostatistics
Fabrice Balavoine – Vice President Research & Development
- 20 years of experience in drug discovery and development
- Held several Executive and R&D positions in biotech companies (Galactis Pharma, Sepal Pharma, Anceris, Cerep)
- Developed several clinical-stage drug candidates (new chemical entities, peptides and recombinant proteins) across various therapeutic areas
- Ph.D. in Organic Chemistry from the University Paris-Sud, M.Sc. from Ecole Supérieure de Physique et de Chimie Industrielle of Paris (ESPCI) and
Executive MBA from the ESSEC & Mannheim Business School
Experienced Management Team
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Professor Mark Caulfield
- Co-director of William Harvey Research Institute, Barts and
The London School of Medicine and Dentistry, Queen Mary University of London (UK)
- Director of the NIHR Biomedical Research Unit in
Cardiovascular Disease at Barts (UK)
- Member of the UK Academy of Medical Sciences
Professor Alexandre Persu
- Head of the Hypertension Clinic, Cardiology Department,
Cliniques Universitaires Saint-Luc, Catholic University of Louvain, Belgium
- Member of the International and European Society of
Hypertension
Scientific & Clinical Advisory Board
Henry Black, MD
- Former President of the American Society of Hypertension
- Led several landmark clinical trials including the Systolic
Hypertension in the Elderly Program
- Member of the Department of Cardiology at the New York
University School of Medicine
Howard Dittrich, MD
- Adjunct Professor of Medicine at the University of Iowa
Carver College of Medicine
- Chairman of the board of Directors of the F. M. Abboud
Cardiovascular Research Center (University of Iowa)
- Cardiologist with >20 years of experience in
cardiovascular research and clinical development
Keith Ferdinand, MD
- Professor of Medicine at the Tulane University School of
Medicine (New Orleans)
- Hypertension specialist certified by the American Society of
Hypertension
- Conducted numerous cardiovascular disease / hypertension
clinical trials especially in racial and ethnic minorities 4
Toshiro Fujita, MD
- Professor of the Department of Clinical Epigenetics, RCAST,
The University of Tokyo
- Former President of the Japanese Society of Hypertension
- Vice-President of the International Society of Hypertension
Frans Leenen, MD
- Director of the Hypertension program at the University of
Ottawa Heart Institute
- Professor of Medicine and Pharmacology at the University
- f Ottawa
- His research focuses on the role of brain mechanisms in
hypertension and congestive heart failure
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Company Highlights
Targeting highly unmet medical needs in resistant hypertension and heart failure Hypertension clinical program with firibastat
Announced on November 12, 2018, excellent results for U.S. phase IIb “NEW-HOPE”. Launch of a pivotal phase III study in Q2 2019. Results expected in H2 2021.
Heart failure clinical program with firibastat
Launch of phase IIb “QUORUM”, proof of concept study in Europe and US, in Q4 2018. Results expected in H2 2020.
Broad intellectual property portfolio
multiple patent families granted or filed, up to 2033.
Novel therapeutic class to treat cardiovascular diseases:
Brain Aminopeptidase A Inhibitors (BAPAIs) provide antihypertensive effects and cardioprotection. Generic name firibastat for QGC001 approved by the World Health Organization.
Experienced management and Scientific/Clinical Advisory Boards
composed of top experts in their fields.
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Development Pipeline
Four R&D Programs based on BAPAI Platform
CONGESTIVE HEART FAILURE HYPERTENSION
First-in-class
Prevention and treatment of congestive heart failure
Firibastat
Proof of efficacy (single dose) in hypertensive rats Regulatory Preclinical results Pharmacokinetics and toxicology (rats and dogs)
First-in-class
Treatment of hypertension as monotherapy
Firibastat
Combination
Treatment of hypertension in combination
QGC011
Best-in-class
Optimized treatment
- f hypertension
as monotherapy
QGC006
Identification of active compounds Preclinical studies Clinical studies Phase I Clinical studies Phase IIa Clinical studies Phase IIb Clinical studies Phase III New drug approval (NDA) Commercia- lisation
Proof of efficacy repeated doses (post infarction rat and dog models) and start of Phase IIb Quantum Genomics Partner
Typically, identification and preclinical phases last 2-3 years, a phase I 1-2 years, a Phase IIa 1-2 years , a Phase IIb 1-2 years, a Phase III 2-3 years and new drug approval and commercialization 2-3 years.
Tolerance, safety and efficacy in hypertensive patients in Phase IIb 6 Nov 12, 2018: Results of U.S Phase IIb trial Q4’18: Initiation of Phase IIb in the EU and U.S.
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Market Data
$40 billion
global anti-hypertensive drug market in 2013 (1)
Sources : (1)The pharmaletter (2014) (2) Heidenreich et al, Circulation Heart Failure (2013). (3) WHO (World Health Organization) - A global brief on hypertension, Silent killer, global public health crisis (2013) (4) National Hospital Discharge Survey, CDC/NCHS and NHLBI,
23 million
people suffer from heart failure worldwide
50% Survival Rate
within 5 years of diagnosis, worse survival rate than most cancers(4)
$39 billion
global heart failure drugs market estimate for 2015 (2)
9.4 million
deaths worldwide every year due to complications of high blood pressure (3)
30% poorly controlled
mostly patients with salt-dependent hypertension. Half of them (15%, 150+ million) have resistant hypertension.
HIGH BLOOD PRESSURE HEART FAILURE
1/3 people worldwide die due to cardiovascular diseases Main cause of death with 17 million deaths per year
1/3 of adults
have high blood pressure. The proportion increases to one-in-two for people above age 50 (1)
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Quantum is targeting areas of high unmet need
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Quantum Genomics is Targeting a Large, Untapped Hypertension Sub-population
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Current blockbuster hypertension drugs only address 70% of the hypertension market
Blockbuster (I.N.N.) Company Diovan (valsartan) Micardis (telmisartan) Benicar, Olmetec (olmesartan) Avapro, Aprovel (irbesartan) Blopress (candesartan)
Quantum Genomics strategy is to develop Firibastat in resistant hypertension
- Resistant hypertension is a high unmet
need (common, leading to high CV morbidity and mortality)
- Firibastat’s MOA(1) makes it effective
whatever the hormone profile (salt- dependent or not)
- Salt-dependent hypertension is common
in elderly, Asian, African American and Hispanic populations
- ACE-I(2) and ARBs(3) have poor efficacy in
salt-dependent hypertension which is
- ften resistant
30% of the hypertensive population is poorly controlled and 15% have resistant hypertension (i.e. uncontrolled despite 3
therapeutic classes including a diuretic)
(1) Mode of action (2) Angiotensin-converting-enzyme inhibitor (ACE-I) (3) Angiotensin-receptor blocker (ARB)
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Other Treatments in Development for Resistant Hypertension Peak sales estimates
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Company Product Mechanism of Action Phase Indication Upcoming Catalyst Aprocitentan Endothelin A & B receptor antagonist Phase III Treatment-Resistant Hypertension Announced enrollment of first patient in PRECISION trial (June ’18) LHW090 Neprilysin inhibitor Phase II Treatment-Resistant Hypertension Initiation of Phase IIb study (YE'18) IONIS-AGT-LRx Angiotensinogen antisense Phase I/II Treatment-Resistant Hypertension Phase I/II Topline Results (2H'18) BAY sGCstim sGC modulator Pre-clinical Treatment-Resistant Hypertension No update
Equity research estimates of annual peak sales in resistant hypertension: For Quantum Genomics, Edison: 2.1 Bio $ For Idorsia, Morgan Stanley and Deutsche Bank: 2.3 Bio $
BAPAI, a novel therapeutic class
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Brain Aminopeptidase A Inhibitors (BAPAIs)
Quantum Genomics, the BAPAI company, is developing first-in-class treatments targeting a new pharmacological pathway in the brain
Hypertension Heart failure Other diseases
Catherine Llorens-Cortes, Ph.D. PhD in Neurobiology, Director of the Central Neuropeptides and cardio-vascular hydro- regulation research team – College de France CIRB-CNRS UMR U1050 7241/INSERM
Novel Therapeutic Approach to Treat Hypertension and Associated Cardiovascular Diseases
BAPAI: Brain AminoPeptidase A Inhibitors
More than 20 years of leading European academic research
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BAPAI Pathway Mechanics
A triple mechanism of action with a single drug
Increase of the diuresis (urinary elimination) Inhibition of Aminopeptidase A (APA) prevents conversion of Angiotensin II into Angiotensin III Innovative novel drugs target a new central pharmacological pathway leading to both antihypertensive effects and cardioprotection Lowering vascular resistance Controlling heart rate
Angiotensin II
BAPAI
Angiotensin III
Vasopressin release Sympathetic nerve activity Baroreflex
Mechanism of action described in several peer-reviewed academic publications *:
Bodineau & al – Hypertension – 2008 Marc & al – ProgNeuroscience – 2011 Marc & al – Hypertension – 2012 * Firibastat (QGC001) also known as RB150
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Reduction in Angiotensin III via APA inhibition results in :
Firibastat for the treatment of hypertension
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Phase I and IIa studies
159 subjects were enrolled and 129 received QGC001
Phase Ia • 2012
Randomized, double-blind, placebo controlled study
- f single ascending doses in 80 healthy volunteers
Positive: overall safety and tolerability
- f firibastat up to 2g
Phase Ib • 2013
Randomized, double-blind, placebo controlled study
- f multiple ascending doses in 44 healthy volunteers
Positive: overall safety and tolerability
- f firibastat up to 750mg twice a day
and no food interaction
Phase IIa • Q1 2015
Initiation of a phase IIa in 34 moderate hypertensive patients
Positive: firibastat led to a decrease in ambulatory (-2,7 mmHg) and office blood pressure (-4,7 mmHg) as compared to placebo and was safe Blood pressure decrease was higher in patients with a higher baseline hypertension
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Q4 2017: Start of NEW-HOPE Phase IIb in hypertension leading to Phase III if successful trial
NEW-HOPE (Novel Evaluation With QGC001 in Hypertensive Overweight Patients of Multiple Ethnic Origins)
Firibastat, Phase IIb Clinical Study Design in Hypertension
Preclinical studies Phase I Phase IIa Phase IIb Phase III New drug approval (NDA) Commercialisa tion
Trial subjects: 250 patients with primary hypertension, overweight
- r obese, at least 50% of African Americans and Hispanics
Trial sites: 38 centres in the United States End of recruitments was announced on September 6, 2018, more than 6 months ahead of initial schedule Excellent results were presented on November 10, 2018, at the late- breaking science session
- f
the American Heart Association meeting in Chicago
Clinical studies
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First-in-class
Treatment of hypertension as monotherapy
Firibastat
- Professor of Medicine at the Tulane
University School of Medicine (New Orleans)
- Hypertension
specialist certified by the American Society of Hypertension
Professor Keith Ferdinand, MD
Tolerance, safety and efficacy in hypertensive patients in Phase II
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Phase II
NEW-HOPE Study
Study design Multicenter, Open-Label, US trial Treatment period: 8 weeks Primary Endpoint : change from baseline in automated office systolic blood pressure (SPRINT-like) Secondary Endpoints : ABPM, safety, PK
BID: twice daily (bis in die); QD: once a daily (quaque die) HCTZ: Hydrochlorothiazide
2 weeks 2 weeks 2 weeks 4 weeks
Run-in (no treatment) Firibastat 250mg BID Firibastat 250mg BID Firibastat 500mg BID If AOBP >140/90 Firibastat 250mg BID Firibastat 500mg BID Firibastat 500mg BID + 25mg HCTZ QD If AOBP >160/110
D56 End of treatment period D28 D14 Baseline D0 Screening
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Study population 256 high-risk, difficult-to-treat hypertensive patients Age: 58.3 years old 100 % overweight – including 65 % obese 28 % type-2 diabetes 53 % minorities patients – including 38 % blacks Baseline AOBP: 154/91 mmHg
BP: Blood Pressure; AOBP: Automated Office Blood Pressure ABPM: Ambulatory Blood Pressure Monitoring Clinicaltrials.gov : NCT03198793
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Change at day 56 P value* Systolic AOBP
- 9.7 mmHg
<0.0001 Diastolic AOBP -4.3 mmHg <0.0001
153.9±7.2 .2 144.3*±14.2 .2
7 14 14 28 28 56 56
N=254 54
*ITT population-LOCF LOCF: Last observation carried forward 95% confidence interval
N=254 54
Firibastat Phase IIb clinical study
Primary Endpoint: change after week 8 in systolic AOBP
Multivariate analysis: baseline blood pressure is the only predictive factor (the higher the initial BP, the larger the effect)
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Black N = 96 Non-Black N = 158 Age, mean (SD), y 57.2 (8.5) 59.0 (10.6) BMI, mean (SD), kg/m² 34.3 (5.1) 32.2 (5.1) Systolic AOBP, mean (SD), mmHg 153.8 (7.1) 154.0 (7.3) Change in systolic AOBP (mmHg)
- 10.5 (14.7)
p<0.0001
- 9.1 (14.2)
p<0.0001
Firibastat Phase IIb clinical study
Effectiveness in subgroups of patients Obese N = 166 Non-Obese N = 88 Systolic AOBP, mean (SD), mmHg 153.8 (7.2) 154.3 (7.3) Change in systolic AOBP (mmHg)
- 10.4 (14.6)
p<0.0001
- 8.3 (13.9)
p<0.0001
In addition, Firibastat had a good safety profile.
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Firibastat
Consistency between experimental and clinical (human) data
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- 35
- 30
- 25
- 20
- 15
- 10
- 5
normotensive rat SHR DOCA-Salt
Rat
Placebo QGC001
- 9
- 7
- 5
- 3
- 1
1
normotensive volunteers unselected hypertensive High-risk, difficult to treat hypertensive
Human
Placebo firibastat Change in blood pressure (mmHg) Change in office blood pressure (mmHg)
Firibastat for the treatment of heart failure
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Based on excellent efficacy data in animals and good safety profile in pilot phase IIa, initiation in Q4 2018 of a Phase IIb trial (QUORUM): efficacy and safety in patients with reduced ejection fraction after acute myocardial infarction, head to head versus reference therapy (ACE-i)
Firibastat, Phase IIb in Congestive Heart Failure
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QUORUM Study Design
- Lead expert in acute coronary syndrome, acute myocardial infarction
- Chairman of the ESC guidelines committee for acute coronary syndrome
- Head of the cardiology department at Hôpital Pitié-Salpétrière, Paris V University.
Other steering committee members: Pr John Alexander (Duke University, USA), Pr Leonardo Bolognese (Toscana University, Italy), Pr Angel Cequier-Fillat (Bellvitge University, Spain), Pr Harald Darius (Vivantes Berlin, Germany), Pr Scott Solomon (Harvard University, USA) Principal investigator: Professor Gilles Montalescot Trial subjects: 294 patients with reduced ejection fraction following acute anterior myocardial infarction Randomized, double-blind, active-controlled, 3 parallel groups (Firibastat 100mg BID, Firibastat 500mg BID, Ramipril 5mg BID), 3 month-treatment period Primary endpoint: change from baseline in left ventricular ejection fraction (Cardiac MRI) Trial sites: approximately 38 hospitals in USA, France, Germany, UK, Spain, Czech Republic, Hungary and Slovakia Results: H2 2020
Efficient organisation and strong assets
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Patent family 1
(granted)
Patent family 2
(granted)
Patent family 3
(granted)
Patent family 4
(filed)
Patent family 5
(filed)
Patent family 6
(filed)
Applicants
(exclusive WW license) (exclusive WW license) (exclusive WW license)
Area of invention Concept of BAPAI to treat hypertension (active ingredient patent) QGC001 for the treatment of hypertension and related diseases QGC006 for the treatment of hypertension and related diseases QGC001 trihydrate form (current product) for the treatment of hypertension and related diseases QGC011 for the treatment of hypertension and related diseases QGC001 L-lysine form for the treatment of hypertension and related diseases Status
Granted Granted Granted
International application
Granted
International application
Granted
International application
Granted
Expiration date
14/01/2019 16/07/2023 * 06/08/2024 ** 07/11/2031* 21/12/2032 * 10/22/2033 *
Patents operated by Quantum Genomics provide secure protection for firibastat up to 2031 (plus possible 5 years extension)
* Potential patent protection extention for 5 years ** Data exclusivity if the patent expires before the date of market availability ( 10 years in France, 5 years in the USA)
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Strong and Broad Intellectual Property Composition of matter patents
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Financials
Simplified Income Statements and Balance Sheet
Audited data in K€ French GAAP FY 2018 FY 2017 Income 71.3 25.7 Personnel expenses (2,402.6) (2,456.0) Other operating expenses (11,266.8) (7,8612.6) OPERATING RESULT (13,598.1) (10,291.9) FINANCIAL RESULT 104,0 (63.3) EARNINGS BEFORE TAXES (13,448.5) (10,631.2) RESEARCH TAX CREDIT 1,458.4 1,150.0 NET INCOME (11,990.1) (9,481.2) Audited data in K€ French GAAP 12/31/2018 Fixed assets 625.5 Inventory/receivables 2,443.1 Cash 14,797.2 Prepaid expenses 614.6 TOTAL ASSETS 18,480,4 Shareholders equity 11,867.7 Other equity (conditional advance) 1,030.0 Provisions 259.7 Financial debt 0.0 Current liabilities 5,323.0 TOTAL EQUITY AND LIABILITIES 18,480.4
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Remaining equity financing facility of 9.1 M€, structured and backed by Kepler Cheuvreux
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Financials
Optimized Cash Management
Data in K€ - audited FY 2018 FY 2017 FY 2016 Net income corrected for non-cash effects (11,828) (9,208) (5,213) Change in net working capital 926.0 1,231 (318) Investments (231) 146 (208) FREE CASH FLOW (11,132) (7,831) (5,736) Capital increase (net) 15,071 7,733 7,744 Borrowings and shareholders’ loans Debt repayment Other elements (mainly Bpifrance loans) (231) (10) 540 FINANCINGS 14,841 7,723 8,284 Change in cash 3,708 (108) 2,545 CASH (END OF PERIOD) 14,797 11,089 11,197
€ 48.6 million
Cash expenses (primarily R&D)
Cash from inception
January 2006 – December 2018
€ 56.0 million
Equity financing
€ 2.4 million
Subsidies/loans from Bpifrance (Public Innovation Bank) and ANR (National Research Agency)
€ 5.0 million
Research Tax Credits (RTC)
Joint capital increases USA & Europe in 2016 and 2017
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Financials
Shareholding & Stock Exchange Information
Stock market data
Listed on Euronext Growth Paris since April 10, 2014. ISIN : FR0011648971; ticker: ALQGC. Trading in the U.S. on OTCQX; symbol: QNNTF. Market capitalisation: 87 M€ as of April 5, 2019.
Potential dilution
Up to 2,180,006 new shares could be issued if all existing common share purchase warrants were to be exercised, which represents 11.6% potential dilution. Total number of shares as of March 31st, 2019: 16,618,985 Capital breakdown as of January 31st, 2019:
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Retail investors
74.9%
Tethys
6.1%
Management
7.8%
Institutional funds
11.2%
A strategy focused on rapid value creation
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Representative Transactions
Acquirer Developer Indication Status Terms
Resistant hypertension Phase II Exercise of license option = Milestone of $230 million, plus Royalties from 20% to 35% according to sales Heart Failure Phase II Acquisition up to $2 billion+, with $300 M upfront and potentially a further $1.775 billion based on development, regulatory and sales related milestones Cardiovascular Phase I Upfront payment + up to €120 million license fees and milestone payments; Servier to continue development of XEN-D0103; Owns commercial rights ex US and Japan
Business Development Strategy
Targeting Partnerships with Big Pharma
Goal
Building an alliance with a pharmaceutical company to develop the BAPAI platform
Upfront/Milestones
Financing clinical and regulatory trials starting from the signature of the license
Royalties
▪ The partner will be in charge
- f marketing and sales activities
▪ Starting sales ASAP after New Drug Approval ▪ Quantum Genomics will receive royalties on sales
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Appendix 1
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Mode of action of major anti-hypertensive drugs
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Appendix 2
QGC011: Combination Program
Target discovery Identification
- f active
compounds Preclinical studies Clinical studies Phase I
Combo BAPAI / IEC
Treatment of hypertension in combination with other antihypertensives/ combination therapy for reduced dosing and reduction of side effects
QGC011
An alternative product to current marketed antihypertensive drugs
Therapeutic solution for patients resistant to existing treatments Synergistic action that allows for dosage reduction and minimized side-effects
Preclinical results demonstrate high interest in combination with the Angiotensin Converting Enzyme inhibitor, Enalapril (Renitec/Vasotec) Synergy of action should improve the control of BP in hypertensive patients
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Firibastat reduces the renal sympathetic nerve hyperactivity and improves left ventricular dysfunction observed in rat post myocardial infarction better than losartan Sham MI size (%) Vehicle Losartan Firibastat Renal sympathetic nerve activity (%) EF (%) LVPSP (mmHg) LVEDP (mmHg) dP/dtmax (mmHg/s)
- 25 ± 1
24 ± 2 24 ± 1 7259 ± 293 17 ± 2 34 ± 2 23 ± 2 20 ± 2 92 ± 2 126 ± 2 3 ± 1 8076 ± 145 66 ± 3 120 ± 1 6116 ± 141 16 ± 2 63 ± 3 6740 ± 63 9 ± 1 118 ± 3 124 ± 2 76 ± 2 9 ± 1 Left ventricular function: MI
Adapted from Huang et al, Cardiovasc Res 2013
Appendix 3
QGC101: BAPAI Rationale for Treatment of Heart Failure
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QUANTUM GENOMICS SA
Tour Montparnasse 33 avenue du Maine 75015 PARIS FRANCE T : + 33 (0)1.85.34.77.70 marc.karako@quantum-genomics.com