Designed Antibodies as Weapons against Infectious Diseases Jan Terje Andersen Department of Biosciences - University of Oslo Department of Immunology - Oslo University Hospital
Viruses 3 http://www.public-domain-image.com/free-imagesh ttp://phil.cdc.gov/phil/quicksearch.asp
Genetic material Protein coat Photo: Dan Higgins. ttp://phil.cdc.gov/phil/quicksearch.asp
The winter vomiting bug
The immune system
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BUBBLE BOY DISEASE 8 Credit: Baylor College of Medicine Photo Archives
Antibiotics and anti-viral drugs
The Body’s Binding to intruder Foot Soldiers Binding to cells 10
Expanding use of therapeutic antibodies • The fastest growing class of bio-therapeutics • The global sale in 2014: >100 billion USD • Autoimmune diseases and cancer • Few against infectious diseases
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Designed foot soldiers Site-specific Improved binding to modifications cell receptors
Killing of a virus in cell cultures 0% 50% 100% Natural antibody Designed antibodies
The soldiers are patrolling the blood
Superior lifespan of antibodies beyond that of natural antibodies Level in blood Designed antibodies Natural antibody Days after injection
• Patient compliance • Economy • Health system
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