d CISMeF & TIBS, LITIS, Rouen Summary of Product Characteristics - - PowerPoint PPT Presentation

Suzanne PEREIRAa,c,d, Blandine PLAISANTINa, Michelle KORCHIAa, Nicolas ROZANESa,b, Elisabeth SERROTa, Michel JOUBERTc and Stefan J DARMONId

a Vidal, Issy les Moulineaux, France b LINALCO, Paris c LERTIM, Faculté de Médecine, Université de la Méditerranée, Marseille d CISMeF & TIBS, LITIS, Rouen

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– basis of information for health professionals on how to use the medicinal product safely and effectively – contains a description of a certain medicinal product’s properties and the conditions attached to its use

Drug composition Pharmaceutical form and strength Authorized applications (indications) Adverse reactions Cautions Safety regulations

• Summary of Product Characteristics (SPC)

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• SPC indexing : extraction of all the information

needed to analyze a prescription and find some inappropriate medications

Drugs Therapeutic indications Contraindications Undesirable effects Precautions for use

Drug Data Base of Vidal Prescription

TUV* terminology

*Unified Vidal Terminology

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• SPC manual indexing : a tedious task

provided by pharmacists that need to be helped

• Evaluation of the performances of F-MTI

(French Multi-terminology indexer) for SPC automatic indexing

5 MeSH, CCAM, SNOMED, TUV et ICD10 terms NOOJ + Dictionnary

• f constituant

Restriction to one or several terminologies Indexing proposition

Bag of Words Algo

Agreggation A Document A corpus of documents (SPC, Discharge summarie, Web site, and others in txt format)

NOOJ + Dictionnary

• f terms

Identification of items, paragraphs and sentences + localisations

Sentences Corpus of sentences Post-treatment

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• Contains pre-validated variants

– All the different textual forms of the actual terms : inflected forms, synonyms, inflected forms of synonyms

ex : asthma : asthma – asthmatic – asthmatics

– DELA Format

ex : asthma,asthma,TUV11 asthmatic,asthma,TUV11 asthmatics,asthma,TUV11

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Sentence: It is contraindicated in case of gastric ulcer. (*Contraindications*)

Dictionary of terms Gastric ulcer,Gastric ulcer,TUV11 ulcères gastriques, Gastric ulcer,TUV11 ulcère de l’estomac, Gastric ulcer,TUV11

Contraindications indexing for the drug: TUV11 Gastric ulcer *Contraindications*

DELA Format NOOJ tool

• Application to a SPC indexing

SPC

*Therapeutic indications* *Contraindications* *Undesirable effects* *Special warnings and precautions for use* *Overdose* *Effects on ability to drive and use machines*

Identification of the different items

Identification

• f sentences

Indexing

F-MTI

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• Method for automatic construction of dictionaries

Example : « diminution des facteurs de coagulation » « decrease of coagulation factors »

3) Creation of new forms (plurals and singulars) 2) Automatic gathering of new variants 1) Integrate the existing variants

• Variants contained in the terminology
• Variants coming from previous projects

(UMLF, MeSH dictionnary of MAIF, lexicons of the VUMeF project)

• Variants extraction from medical and pharmaceutical

corpus (~50,000 documents)

• Using syntactic graphs and a word dictionnary
• Using a simple algorithm (terms < 3 words)

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• TUV application

– 23,800 forms found in other lexical resources – 550 new inflections generated (After precision of 55%)

• Creation of 11,975 transducers linked to a dictionnary of

38,219 word forms

• Corpus of 50,000 medical and pharmaceutical documents

– 4,279 plurals/singulars created (After precision of 92,3%)

TUV dictionary contains 40,266 inflection forms and synonyms for 11,965 terms

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Code Term Item

TUV11 Gastric ulcer TUV63 Colitis, ulcerative TUV1200 Hypersensitivity TUV200 Child TUV101 Diarrhea

Indexing Manually Automatically SPC

*Therapeutic indications* *Contraindications* *Undesirable effects* *Special warnings and precautions for use* *Overdose* *Effects on ability to drive and use machines*

Identification of the different items and sentences

5,191 SPCs

*Contraindications*

Code Term Type

TUV11 Gastric ulcer Contraindication TUV63 Colitis, ulcerative Contraindication TUV1200 Lactose intolerance Precautions for use TUV200 Child less than 15y. Precautions for use TUV101 Diarrhea Precautions for use *Precautions for use* *Precautions for use* *Contraindications* *Contraindications*

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Categories

Precision (%) Recall (%)

Indication 48.1 21.7 Contraindication 46.1 23.5 Adverse effect 77.0 59.4 Precaution for use 28.4 49.3 All types of terms 52.9 46.2 The entire document indexing 57.6 43.4

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• Advantages and disadvantages of the

dictionary of terms method

– very quick method of indexing documents (less than one minute for our entire corpus) – inflection forms and synonyms are validated before indexing ( generate a minimum of errors) – the quality of the indexing depends on the coverage of the different forms for the terms of a terminology (our dictionary is actually insufficient)

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• Enhance the quality of SPC indexing

– Integration of TUV indexing rules – A better assignation of term types – XMLization of SPCs

• Integration in an helping tool for manual SPC

indexing (BIBLIS)

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• Development of an automatic dictionary

construction method

• Evaluation of a French Multi-Terminology

Indexer to index SPCs with TUV terms

• To help drug properties information extraction

for drug prescription safety

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• The authors would like to thank Vidal, CISMeF and

LERTIM teams for their help in the study design and result analysis.

• J.F. Bergmann and al. Good medical practice for drugs. Definition, guidelines,

references, fields of action and applications, Therapie 63 (2008), 4:267-80.

• S. Pereira, P. Massari, M. Joubert, E. Serrot, S.J. Darmoni. Exploring Multi-

terminology Indexing of Discharge Summaries, Stud Health Technol Inform (2008).

• S. Pereira, A. Névéol, G. Kerdelhué, E. Serrot, M. Joubert, S.J. Darmoni.

Using multi-terminology indexing for the assignment of MeSH descriptors to health resources in a French online catalogue. AMIA Annu Symp Proc (2008), 586-90.

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• Contact
• suzanne.pereira@vidal.fr