Lecture in INF5890 April 26th 2016
Critical Perspectives on Management, Governance and Control of ICT
Margunn Aanestad
Critical Perspectives on Management, Governance and Control of ICT - - PowerPoint PPT Presentation
Lecture in INF5890 April 26th 2016 Critical Perspectives on Management, Governance and Control of ICT Margunn Aanestad Today: Critique of traditional management approaches Too much reliance on command and control Alternative
Lecture in INF5890 April 26th 2016
Margunn Aanestad
Chapter 2: A Critical Review of the Literature on the Management
Asset: «A resource with economic value that an individual, corporation or country
– Different national regulation (accounting, tax, environmental impact) – Different market models and business cultures
– Customized for every division
Support services Network, OS, PC’s Desktop- applications SAP Lotus Notes user interface Web-browsere Lotus Notes database
Naturally, managers and consultants tend to downplay challenges and emphasize achievements. But what about researchers? Do we need to «go deeper»?
Traditional managerial approach (Deming) Double loop learning (Argyris)
Some of the external parties that NAV systems communicate with
EXOM base med varians filer EXOM base funksjonell annotering Klinisk algoritme/ Ekspert system
Gradert tilgang avhengig av klinisk spørsmål/ bruk og tillatelser Brukere PASIENTER Pleietjeneste? Allmennlege Spesialister
Spesial IT systemer Ekspert/ Med. genetiker Tillatelse til bruk fra pasient LOGG for queries, bruker
Genom- data Hva er CYP3A5, CYP3A4 og POR? CYP3A5 *1/*3 CYP3A4 *18/*1b POR *28/*28
Genom- data Hvordan doserer jeg Marevan for akkurat denne pasienten? Et øyeblikk
Bzzbzz.. CYP2C9..bzzbzz.. VCORKC1 Bzzbzz.. CYP2C9*1..bzzbz z..VCORKC1*3
Almenpraktiker
Genom- data Er dette den arvelige formen for kardio- myopati? Et øyeblikk
Bzzbzz.. MYH7..bzzbzz… TNNT2..TPM1… Bzzbzz.. MYH7..bzzbzz… TNNT2..TPM1…
Hei! Den varianten har jeg aldri sett før! Hjelp meg, Kjære genetiker! Hm… stoppkodon midt i myomet, det kan umulig gå bra Ok.
Almenpraktiker Genetiker
Sample loading and QC Frequency and inheritance External databases References Pathogenicity prediction Final evaluation and report Matching against in-house DB
Gene Variant (HGVS) Norvariome ESP6500 1000G Contradictory information Filter out : Select all BRCA1 c.434A>C 0.0234
c.2311T>C
Variant (HGVS) Norvariome ESP6500 1000G Contradictory information Filter out : Select all BRCA1 c.873T>C
c.1067A>G
Details for variant BRCA1 c.1067A>G
HGVS cDNA c.1067A>G Observed genotype CA HGMD Pro Disease-associated polymorphism Effect Missense SIFT TOLERATED MutationTaster Polymorphism
View raw
View all
View external record
genAP
analysis workbench
VarDB Sample Options | Sign out | Help External DB Prediction References Report Next Previous Frequency Neutral variants (>0.008) Sample 000001A loaded | Gene panel: Breast and ovarial cancer v1.0 Probably neutral variants (0.001-0.008) Only variants with frequency >0.008 are shown. Filter
Mockup v0.1
Removes checked variants from further analysis, adds to report. Pathogenicity prediction tools Extracting, adding and scoring of references Report with all details, suggested classification and export tools External databases In-house database Sample loading
BIC ClinVar dbSNP HGMD Pro SeqScapeDetails for selected variant.
(”The Cynefin framework”)