CRISPR Ethics: New Challenges, or Nothing New Under the Sun? Robin - PowerPoint PPT Presentation

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CRISPR Ethics: New Challenges, or Nothing New Under the Sun? Robin Pals Rylaarsdam Benedictine University Lisle, Illinois Outline 1. CRISPR technology 2. Current documented uses of CRISPR a. Human health and disease b. Environmental and

CRISPR Ethics: New Challenges, or Nothing New Under the Sun? Robin Pals Rylaarsdam Benedictine University Lisle, Illinois
Outline 1. CRISPR technology 2. Current documented uses of CRISPR a. Human health and disease b. Environmental and agricultural applications 3. Ethical concerns: a. Human genetic modifications b. Environmental impacts 4. Old or new? Or some of both?
Background: CRISPR Technology By Guido4 - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=63789047 By Guido4 - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=63789049
Why is CRISPR a game-changer? Efficiency Specificity Cost
Current uses of CRISPR: basic research
Current uses of CRISPR: basic research
Current uses of CRISPR: genetic modification of whole organisms Nature 553: 217-221, 11 Jan 2018
Newly developing uses of CRISPR: Diagnostic tests for viruses
Developing uses of CRISPR: Ex vivo genetic modification of human cells
Developing uses of CRISPR: genetic modification of human embryos
Ethical Concerns: Human germline modifications ● Practical considerations: PGD parallels ● Ethical considerations for changing future generations: ○ Autonomy and self-determination ○ Unintended consequences ○ Nature of humanity
Developing uses of CRISPR: Agriculture
Developing uses of CRISPR: Pest management By Muhammad Mahdi Karim - Own work, GFDL 1.2, https://commons.wikimedia.org/w/index.php?curid=9556152
Ethical Concerns: Ecosystem changes and Gene Drive By Mariuswalter - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=62766590
Developing uses of CRISPR: De-extinction By Mauricio Antón - from Caitlin Sedwick (1 April 2008). "What Killed the Woolly Mammoth?". PLoS By James St. John - Ectopistes migratorius Biology 6 (4): e99. DOI:10.1371/journal.pbio.0060099., CC BY 2.5, (passenger pigeon) 5, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=11781070 https://commons.wikimedia.org/w/index.php?curid=39 354081
Considerations ● Unintended consequences ● Wise use of finite resources ● Health of “de-extincted” population

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