CRISPR Ethics: New Challenges, or Nothing New Under the Sun? Robin - - PowerPoint PPT Presentation

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CRISPR Ethics: New Challenges, or Nothing New Under the Sun? Robin - - PowerPoint PPT Presentation

Feb 04, 2024 562 likes •736 views

CRISPR Ethics: New Challenges, or Nothing New Under the Sun? Robin Pals Rylaarsdam Benedictine University Lisle, Illinois Outline 1. CRISPR technology 2. Current documented uses of CRISPR a. Human health and disease b. Environmental and

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CRISPR Ethics: New Challenges, or Nothing New Under the Sun?

Robin Pals Rylaarsdam Benedictine University Lisle, Illinois

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Outline

  • 1. CRISPR technology
  • 2. Current documented uses of CRISPR
  • a. Human health and disease
  • b. Environmental and agricultural applications
  • 3. Ethical concerns:
  • a. Human genetic modifications
  • b. Environmental impacts
  • 4. Old or new? Or some of both?
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Background: CRISPR Technology

By Guido4 - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=63789047 By Guido4 - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=63789049

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Why is CRISPR a game-changer? Efficiency Specificity Cost

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Current uses of CRISPR: basic research

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Current uses of CRISPR: basic research

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Current uses of CRISPR: genetic modification of whole organisms

Nature 553:217-221, 11 Jan 2018

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Newly developing uses of CRISPR: Diagnostic tests for viruses

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Developing uses of CRISPR: Ex vivo genetic modification of human cells

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Developing uses of CRISPR: genetic modification of human embryos

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Ethical Concerns: Human germline modifications

  • Practical considerations: PGD parallels
  • Ethical considerations for changing future

generations: ○ Autonomy and self-determination ○ Unintended consequences ○ Nature of humanity

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Developing uses of CRISPR: Agriculture

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Developing uses of CRISPR: Pest management

By Muhammad Mahdi Karim - Own work, GFDL 1.2, https://commons.wikimedia.org/w/index.php?curid=9556152

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Ethical Concerns: Ecosystem changes and Gene Drive

By Mariuswalter - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=62766590

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Developing uses of CRISPR: De-extinction

By Mauricio Antón - from Caitlin Sedwick (1 April 2008). "What Killed the Woolly Mammoth?". PLoS Biology 6 (4): e99. DOI:10.1371/journal.pbio.0060099., CC BY 2.5, https://commons.wikimedia.org/w/index.php?curid=11781070 By James St. John - Ectopistes migratorius (passenger pigeon) 5, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=39 354081

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Considerations

  • Unintended consequences
  • Wise use of finite resources
  • Health of “de-extincted” population