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Complexity Yesterday, Today, Tomorrow Peter Schuster Institut fr - - PowerPoint PPT Presentation
Complexity Yesterday, Today, Tomorrow Peter Schuster Institut fr - - PowerPoint PPT Presentation
Complexity Yesterday, Today, Tomorrow Peter Schuster Institut fr Theoretische Chemie, Universitt Wien, Austria and The Santa Fe Institute, Santa Fe, New Mexico, USA Complexity Science Hub Vienna Visions for Complexity Wien, 23.05.2016
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Complexity may result from lack of insight
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Sacrobosco‘s Tractatus de Sphaere, 1230 Pythagoras, 575 – 495 BC
celestial spheres and epicycles
Isaac Newton, 1643 - 1727
b m F r m m g F F × = × = = ;
2 2 1 2 1
law of gravity
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Complexity may result from lack of methods
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deterministisches chaos
Henri Poincaré, 1854 -1912 Wilhelm Ostwald, 1853-1932
spatiotemporal pattern in chemical reactioons
Alan Turing, 1912 - 1954
mathematics of chemical pattern formation
Edward N. Lorenz, 1917-2008
combined analytical and numerical approaches in the analysis of complex systems and many others.
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Complexity may be inherent in the system
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The reaction network of cellular metabolism published by Boehringer-Mannheim.
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Christopher R. Bauer, Andrew M. Epstein, Sarah J. Sweeney, Daniela C. Zarnescu, and Giovanni Bosco. Genetic and Systems level analysis of Drosophila sticky/citron kinase and dFmrl mutants reveal common regulation of genetic networks. BMC Systems Biology 2:e101 (2008).
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Hongwu Ma, An-Ping Zeng. Reconstruction of metabolic networks from genome data and analysis of their global structure for various
- rganisms. Bioinformatics 18:270-277 (2003).
Escherichia coli
reversible reactions irreversible reactions
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Robert Schuetz, Nicola Zamboni, Mattia Zampieri, Matthias Heinemann, Uwe Sauer. Multidimensional optimality of microbial metabolism. Science 336:601-604 (2012)
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Sydney Brenner, 1927 - …… the prime intellectual task of the future lies in constructing an appropriate theoretical framework for biology …… theoretical biology has a bad name because of its past …… I have decided to forget and forgive the past and call it –the badly required new discipline – theoretical biology.
Sydney Brenner. Theoretical biology in the third millenium. Phil.Trans.Roy.Soc.London B 354:1963-1965, 1999
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Complexity will be manageable in the future only by the right combination of rigorous mathematical analysis, big ig da data and computer simulation
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Thank you for your attention!
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Web-Page for further information: http://www.tbi.univie.ac.at/~pks
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Die Bakterienzelle als Beispiel für die einfachste Form autonomen Lebens Das Escherichia coli Genom: 4 Millionen Nukleotide 4460 Gene
Die räumliche Struktur des Bakteriums Escherichia coli
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Robert Schuetz, Nicola Zamboni, Mattia Zampieri, Matthias Heinemann, Uwe Sauer. Multidimensional
- ptimality of microbial metabolism. Science 336:601-604 (2012)
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Sir Peter Brian Medawar, 1915 - 1987
…… no new principle will declare itself from below a heap of facts. ……
Torbjörn Fagerström, Peter Jagers, Peter Schuster, and Eörs Szathmáry. Biologists put on mathematical glasses. Science 271:2039-240, 1996.
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Theodosius Dobzhansky, 1900 - 1975
Nothing makes sense in biology except in the light of evolution, …
Theodosius Dobzhansky. Biology, molecular and organismic. American Zoologist 4:443-452, 1974.
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Turing patterns in embryological morphogenesis: „…… although reaction-diffusion theory provides a very elegant mechanism for segmentation, nature seems to have chosen a much less elegant way of doing it.“
Philip Maini, 1959 - Alan M.Turing, 1912 - 1954 Philip K. Maini, Kevin J. Painter, and Helene Nguyen Phong Chau. Spatial pattern formation in chemical and biological systems. J.Chem.Soc., Fraday Trans. 93:3602-3610, 1997.