SLIDE 1
Cocaine
http://www.nida.nih.gov/pubs/teaching/
Cocaine http://www.nida.nih.gov/pubs/teaching/ PET study and slot - - PowerPoint PPT Presentation
Cocaine http://www.nida.nih.gov/pubs/teaching/ PET study and slot - - PowerPoint PPT Presentation
Cocaine http://www.nida.nih.gov/pubs/teaching/ PET study and slot machine study [ 11 C] raclopride tracer Iowa Gambling Task (IGT) 18 GDS og 16 HC Baseline & control Ventral striatum [ 11 C] raclopride tracer Iowa
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- [11C] raclopride tracer
- Iowa Gambling Task (IGT)
- 18 GDS og 16 HC
- Baseline & control
- Ventral striatum
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SLIDE 5
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- [11C] raclopride tracer
- Iowa Gambling Task (IGT)
- 18 GDS og 16 HC
- Baseline & control
- Ventral striatum
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- 15 GDS vs 15 HC
- 2s vs 3s Event Frequency
- 50% vs 83% Reward Return
- Variable Reward Frequency
- Randomized order
- Up to 60 min. gambling
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Fallacy I:
Gambling Disorder Sufferers have lower baseline binding potentials
SLIDE 9
Volkow et al. (2002). Neurobiology of Learning and Memory 78, 610–624
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Controls Bmax/Kd Abusers Bmax/Kd p Alcoholics 2.71 0.6 (n 17) 2.10 0.5 (n 10) 0.05 Heroin abusers 2.97 0.5 (n 11) 2.44 0.4 (n 11) 0.01 Cocaine abusers 2.90 0.3 (n 23) 2.59 0.3 (n 20) 0.01 METH abusers 2.81 0.3 (n 20) 2.45 0.3 (n 15) 0.001
Volkow et al. (2002). Neurobiology of Learning and Memory 78, 610–624
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Volkow et al. (2002). Neurobiology of Learning and Memory 78, 610–624 Linnet et al. (2010). Acta Psychiatr Scand: 122: 326–333
Controls Bmax/Kd Abusers Bmax/Kd p Alcoholics 2.71 0.6 (n 17) 2.10 0.5 (n 10) 0.05 Heroin abusers 2.97 0.5 (n 11) 2.44 0.4 (n 11) 0.01 Cocaine abusers 2.90 0.3 (n 23) 2.59 0.3 (n 20) 0.01 METH abusers 2.81 0.3 (n 20) 2.45 0.3 (n 15) 0.001
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Clark et al. (2012). Neuroimage: 63: 40-46
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VLS ADC PDC ADP PDP GP 1 2 3 4 5
[11C]raclopride BPND
Boileau et al. (2013). Addiction: 108 (5): 953-963
PG HC ventral striatum anterior dorsal putamen posterior dorsal putamen
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Gambling Disorder Sufferers differ in magnitude of dopamine release when gambling
Fallacy II:
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Volkow et al. (1997). Nature, Apr 24;386(6627), 830-3
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Linnet et al. (2010). Acta Psychiatr Scand: 122: 326–333
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Gambling Disorder Sufferers differ in magnitude of dopamine release when winning
Fallacy III:
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Steeves et al. (2009). Brain: 132; 1376–1385
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Steeves et al. (2009). Brain: 132; 1376–1385
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Steeves et al. (2009). Brain: 132; 1376–1385