Cloud-Based Drug Design and Development Cavendish Global Health - - PowerPoint PPT Presentation

www.cloudpharmaceuticals.com

Cloud-Based Drug Design and Development

Cavendish Global Health Impact Forum October 25-28, 2015

Pancreatic Cancer

Key statistics for 2015 from the American Cancer Society:

Source: American Cancer Society, Inc.

50,000

People diagnosed

40,560

Will die from pancreatic cancer

3%

Of all cancers in the US

7%

Of all cancer deaths in the US

Finding a Cure

Targets pancreatic cancer using real genomics data Uses genome data and DNA analysis to discover novel drug targets Designing drug leads for those targets

Central Nervous System Diseases

Alzheimer’s

50,000

Americans have it

2/3

Are women

6th

leading cause of death cause of death in the top 10 in America that can't be prevented, slowed, or cured

Only

Amyotrophic Lateral Sclerosis

Progressive degeneration of motor nerve cells in the brain and spinal cord Does not impair your intellect or senses Impairs voluntarily and involuntary muscles Often results in respiratory failure Considered by NIH as orphan disease

Source: Alzheimer’s Association Source: The Johns Hopkins University

Finding a Cure

AI technology identifies novel targets by souring published research enabling basket trials Designs drug leads for those targets and filters for drug properties such as blood–brain barrier

Virtual Molecular Space

Contains every small molecule to increase the wellness of people around the world, to prevent people from dying, and to relieve their pain and suffering

The trick is to find the right ones

Our Mission

Improve health

and well-being through the rapid and efficient design of new medicines

Design small

molecules that drug novel targets produced by pathologies

Apply cloud

computing and computational chemistry to design drugs

Pre-qualified candidates enable us to reduce cost, accelerate development, and target elusive indications

The Time is Now for In Silico Why?

• Moore's Law
• Accessibility of cloud-based super computing
• Artificial intelligence
• Store 3D model of every human protein in the

druggable genome

• Analyze a proposed drug for toxicity prior to

clinical trial

How?

Emerging life sciences data center

Valuable Relationships

Collaboration developing 12 drugs, validation data Grant for development of discovery methods and select drugs Muscle growth and inflammation research Autism and cancer research Paid proof of concept Malaria collaboration Collaboration developing 7 drug programs Drug discovery platform to model and analyze druggable genome

How Do We Develop Medicines for Challenging Diseases?

Identify the molecules with outstanding drug-like properties that modulate the activity of protein targets

Apply

the right technology

Partner

with visionary companies

Harness

the trends of the digital revolution

Questions?

Ed Addison, CEO Cloud Pharmaceuticals Inc. 6 Davis Drive Research Triangle Park, NC 27709 (910) 398-1200 ed.addison@cloudpharmaceuticals.com www.cloudpharmaceuticals.com