Charles Baum, M.D., M.S., FACG, FTOS Vice President and Head U.S. - - PowerPoint PPT Presentation

Charles Baum, M.D., M.S., FACG, FTOS Vice President and Head U.S. Medical Affairs Vice President and Head U.S. Medical Affairs Takeda Pharmaceuticals International

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Recognizing Obesity as a Disease

• Obesity recognized as a disease
• American Medical Association (June 2013)

Ob it G id li /P iti St t t Surgery Surgery Obesity Guidelines/Position Statements AACE ENDO/TOS ACP VA/D D Pharmacotherapy Pharmacotherapy Lifestyle Modification Lifestyle Modification VA/DoD AGA Lifestyle Modification Lifestyle Modification Diet Diet Physical Activity Physical Activity

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Multifaceted Medical Weight Loss Approaches Are Most Effective Approaches Are Most Effective

• In a randomized clinical trial of obese patients, those subjects who received

combination therapy lost more weight than subjects undergoing a structured lifestyle i i h h l

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intervention or pharmacotherapy alone1

2 4 g

Pharmacotherapy alone (n=45) Structured Lifestyle Intervention alone (n=47) Combined Therapy (pharmacotherapy + Structured lifestyle Intervention) (n=49)

4 6 8 10 Weight Loss, kg 3 6 10 18 40 52 12 14 16 Weeks W

• Another randomized controlled prospective study found significantly greater mean

weight loss with pharmacotherapy plus lifestyle intervention after 1 year and 4 years compared with lifestyle intervention alone (p<0 001)2

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compared with lifestyle intervention alone (p<0.001)2

• 1. Wadden et al, N Engl J Med 2005; 353:2111-20 (adapted with permission)
• 2. Torgerson et al, Diabetes Care 2004;27:155-61

New Approaches to Obesity Pharmacotherapy: Designed to maximize weight loss, maintenance, g g , , program adherence, access & affordability

Product

• Safe and effective for both weight loss induction

and weight maintenance including novel dosing regimens

• Evidence for improvement in clinical outcomes and
• verall cost
• Evidence-based lifestyle/BMOD program results in

Program

y p g additive effects on weight loss and adherence

• Program is integrated into benefits design
• Sustainable

Affordable

• Voucher programs insure affordable pricing
• Reliable price with progressive savings at

Access

retail pharmacy (behavioral economics)

• Novel payer partnerships such as risk-based

contracting are needed to enhance coverage

Digital technology expands reach and allows for personalized tailoring: The ScaleDown approach

• Results

− Higher engagement, lower recidivism with lower intensity − Comparable weight loss as seen with f t f lif t l t face to face lifestyle management programs DPP Look Ahead ScaleDown

Weight loss 7% 5% 7% > 5% weight loss at 6 months 50% 43% 43%

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Face to face sessions 16 28 1

Comprehensive Community Approaches to Obesity

Individuals, Families, Communities, Society

Schools Businesses Faith-Based Initiatives

ics

Physical

Med Mess l Economi

Healthy Food Environment Physical Activity Opport.

dia ages Behaviora

Healthcare Systems

B

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Obesity Treatment

Baum C. Pharmacoeconomics. 2015 Feb 17. [Epub]