Cell Commitment and Epigenetic Memory Reprogramming Embryonic stem - PowerPoint PPT Presentation

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Cell Commitment and Epigenetic Memory Reprogramming Embryonic stem cells Lineage potential Differentiation Progenitor cells Transdetermination De-differentiation Specialised cells Transdifferentiation Lymphocyte Reprogramming strategies

Cell Commitment and Epigenetic Memory
Reprogramming Embryonic stem cells Lineage potential Differentiation Progenitor cells Transdetermination De-differentiation Specialised cells Transdifferentiation Lymphocyte
Reprogramming strategies Somatic cell nuclear transfer (SCNT) Transcription-factor transduction Cell fusion
mES x hB Oct4 translocates 3h 6h 12h mES x hB hES hB 6h 12h 24h Nuclear volume increasing
ES hB hB mES x hB hES 24h Nucleoli reorganize H4K16ac increases H3K9me3 control mES x hB (PRC2 -/- ) H3S10ph increases HP1 α redistributes
MRC Clinical Sciences Centre and collaborators : Imperial College London Andrew deMello Neil Brockdorff • Tomomi Tsubouchi • Jorge Soza-Ried THANKS • Francesco Piccol Hakan Bagci • • Karen Brown • Irene Cantone • David Landeira Feng Li • • Matthias Merkenschlager and other members of the Lymphocyte Development Group (past and present)

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