Cell Commitment and Epigenetic Memory Reprogramming Embryonic stem - - PowerPoint PPT Presentation

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Mar 12, 2023 281 likes •431 views

Cell Commitment and Epigenetic Memory Reprogramming Embryonic stem cells Lineage potential Differentiation Progenitor cells Transdetermination De-differentiation Specialised cells Transdifferentiation Lymphocyte Reprogramming strategies

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Cell Commitment and Epigenetic Memory

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Embryonic stem cells Progenitor cells Specialised cells

Reprogramming

Transdifferentiation De-differentiation Transdetermination Differentiation Lineage potential

Lymphocyte

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Somatic cell nuclear transfer (SCNT) Transcription-factor transduction Cell fusion

Reprogramming strategies

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3h 6h 12h

mES x hB

Oct4 translocates

6h 12h 24h

mES x hB hB hES

Nuclear volume increasing

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mES (PRC2-/-) x hB

mES x hB hB hES

Nucleoli reorganize H4K16ac increases H3K9me3 control H3S10ph increases HP1α redistributes hB ES 24h

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MRC Clinical Sciences Centre Imperial College London

Tomomi Tsubouchi
Jorge Soza-Ried
Francesco Piccol
Hakan Bagci
Karen Brown
Irene Cantone
David Landeira
Feng Li
Matthias Merkenschlager

and other members of the Lymphocyte Development Group (past and present) and collaborators : Andrew deMello Neil Brockdorff

Cell Commitment and Epigenetic Memory

Reprogramming

THANKS