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Carnitol A specific formulation for horses Carnitol, a special formulation for horses A unique combination Carnitol is a unique combination of ingredients selected to stimulate energy metabolism and to optimize overall performances of

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Carnitol

A specific formulation for horses

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A unique combination

  • Carnitol is a unique combination of ingredients selected to

stimulate energy metabolism and to optimize overall performances

  • f horses

Carnitol, a special formulation for horses

L-Carnitine Sorbitol Plant extracts Magnesium

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Carnitine, a key ingredient

  • Carnitine, derived from an amino acid, is

found in nearly all cells of the body.

  • Carnitine is the generic term for a number of

compounds that include L-carnitine, acetyl-L- carnitine, and propionyl-L-carnitine.

  • The D-form does not occur in nature but may

be obtained by chemical synthesis. The D isomer of carnitine is biologically inactive and it also hinders activities of L-carnitine.

Carnitol, a special formulation for horses

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L- Carnitine : Main applications

SPORT ANIMALS HORSES SPECIAL EFFECTS LIVESTOCK Muscle Buffer function Liver protection Buffer function Reproduction energy status Detoxification Fertility Growth Myocard Immune system Feed coversion Membranes effects Source : practical experiences with l-Carnitine Dr Stephan Jacobs (Cuxhaven, germany) lohmann information

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L-Carnitine, a key ingredient for horses

  • Convert fat into energy.

– Improve energy metabolism and energy feed convertion

  • Cardio-vascular system

– Heart energy comes mostly from fat and L-Carnitine

  • Antioxidant support

– Serves as an antioxidant

  • Maintaining muscle integrity

– provide blood flow to smooth muscles

Carnitol, a specific formula for horses

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L-Carnitine, a key ingredient for improving the glucose metabolism

Carnitine plays a critical role in energy production. It transports long-chain fatty acids into the mitochondria so they can be oxidized ("burned") to produce energy (ATP) during the Beta oxydation process. Fats under long- chain fatty acids, constitutes an important source of energy for horses , at calm period or different intensive activities. It improves the efficiency of energy turn over.

Carnitol, a specific formula for horses

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L-Carnitine, maintain muscle integrity

By allowing a complete oxidation of the carbon hydrates which limits the formation of lactic acid By reducing the amount of harmful toxins produced during hard work it means less muscle damage and a better recovery.

Carnitol, a specific formulation for horses

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L-Carnitine, for foals, yearling,..

. The plasmatic concentration of carnitine increase with age by an improvement of the endogenic biosynthesis of the carnitine. (Foster et al. 1989) A supplementation in carnitine is recommended for pre-matured foals and young animals under two years old. Benamou and harris 1993 demonstrate that a supplementation in carnitine in the mare increase the concentration of carnitine in the plasma of their foals.

Carnitol, a specific formulation for horses

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L-Carnitine, for stallion fertility

  • Studies on others species show that a

supplementation in carnitine has benefic results on the spermatozoid caracteristics. (Jacyno et al. 2007)

  • Carnitine is also a mark for the viability of

the sperm after a fridge storage for an AI. (Stardaioli et al. 2000)

  • And at least carnitine supplementation act
  • n hypo fertil stallion by an improvement
  • n the formation and motility of the
  • sperms. (Stradaiolo et al.2004)

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L-Carnitine, for horse with metabolic syndrome (overfat horses)

A supplementation in carnitine upon its good effect on insulino sensibility improve the intake of glucids by the organism (van Weyenberg et al. 2009) and also increase the level of leptin in the blood after the feed intake . Leptin help to reduce appetite and so to prevent from obesity for horses and poneys.

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L-Carnitine, supplementary sources

  • Carnitine occurs naturally in microorganisms, plants and animals.
  • The major dietary sources are red meat, poultry, fish and dairy

products [59]. Animal meals contain 10 to 20 times more L- carnitine than plant-based feedstuffs.

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L-Carnitine for animal health

  • Because feedstuffs are mainly

composed by non-animal raw materials, it is useful to incorporate L-carnitine into diets to ensure that animals receive adequate amounts of L-carnitine.

Carnitol, a specific formulation for horses

  • L-carnitine oral supplementation is recommended in case of

metabolic burdens such as exercise, heat or cold exposure or when energy demands are elevated (growth in young animals, high zootechnical performance or fat-enriched diet).

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L-Carnitine, distribution

  • L-carnitine oral supplementation can be

realised either in the drinking water or directly in the diet. Since this compound is easily dissolved in water, the drinking water is often preferred to achieve a homogeneous mixture.

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Sorbitol, choleretic and cholagogue

  • Sorbitol is especially indicated for its favorable effect on liver

metabolism.

  • Sorbitol increases the secretion of digestive enzymes (pancreatic one)

and therefore promotes good digestion of feed and avoids fat

  • verload by increasing the production of bile salt (choleretic and

cholagogue effect)

  • Sorbitol acts as an osmotic substance and facilitates the elimination of

toxic products. (lactic acid)

Carnitol, a specific formulation for horses

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Magnesium

  • Magnesium is the fourth most abundant

cation in the body and plays an important physiological role in many of its functions.

  • Magnesium balance is maintained by renal

regulation of magnesium reabsorption.

Carnitol, a specific formulation for horses

  • Magnesium has a key role in many biological processes such as

cellular energy metabolism, cell replication, and protein synthesis.

  • Magnesium allows horses to manage adrenaline rushes when

they become stressed.

  • Magnesium also plays a huge role in allowing muscles to stay

supple.

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Plant extracts :

Artichock (Cynara scolymus)

  • The active contituents of C. scolymus are

mainly flavonoids and caffeoylquinic acid

  • These compounds have been proved to

have hepatoprotective activity, hypolipidemic effect, antioxidant capacity and anti-inflammatory properties

Carnitol, a specific formulation for horses

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Plant extracts :

Gentiana (Gentiana lutea)

  • The active principles are the bitter tasting

secoiridoid glycosides gentiopicrin and amarogentin.

  • G. lutea is very popular as a stomachic as

well as a component in preparations showing beneficial effects in gall and liver diseases

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Carnitol, a specific formulation for horses

Magnesium Energy metabolism Protein synthesis help the horses to manage stressful situation and to keep supple muscle. Plant extracts Hepatoprotective and digestive functions AROMA Sorbitol Encourages bile production and secretion Stimulates liver activity L-carnitine Transports long chain fatty acids Allows storage and release of fats in case of high energy needs Impact on milk mare, foals, stallion, racing horse.

Energy metabolism improvement

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Carnitol, a specific formulation for horses

Carnitol, advance formulation

  • L-carnitine : 60 000 mg/L
  • Sorbitol liquid : 360 g/L
  • Magnesium chloride hexahydrate

170 g/L

  • Plant extracts : Cynara scolymus

and Gentiana lutea

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Carnitol, a specific formulation for horses

Direction for use

  • Poultry, swine:

1ml/L of drinking water for 3 to 5 days

  • Cattle, camels,

horses: 20 ml/100kg body weight per day.

  • Sheep, goats,

calves: 4 ml/10 kg body weight per day.

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  • Bibliographie
  • Benamou, A. E. and R. C. Harris (1993). Effect of carnitine supplement to the dam on plasma carnitine

concentration in the sucking foal. Equine veterinary journal 25(1): 49-52.

  • Biagi, G., R. Luddi, et al. (1985). Use of l-carnitine in the working American trotting horse. Atti della Societa

Italiana delle Scienze Veterinarie

  • 39(2): 305-308.
  • Foster, C. V., R. C. Harris, et al. (1989). Survey of plasma free carnitine levels
  • in 74 Thoroughbred horses at stud and in training. Equine veterinary journal 21(2): 139-141.
  • Foster, C. V. L. and R. C. Harris (1989). Plasma carnitine concentrations in the
  • horse following oral supplementation using a triple dose regime. Equine Veterinary Journal 21(5): 376-377.
  • Foster, C. V. L., R. C. Harris, et al. (1988). The effect of oral L-carnitine
  • supplementation on the muscle and plasma concentrations in the Thoroughbred horse. Comparative

Biochemistry and Physiology, A (Comparative Physiology) 91(4): 827-835.

  • Iben, C., E. Moschitz, et al. (1999). Effect of L-carnitine supplementation on
  • heart rate and some blood parameters in the eventing horse. Wiener
  • Tierarztliche Monatsschrift 86(10): 330-338.

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  • Jacyno, E., Ako?odziej, et al. (2007). Effect of L-carnitine supplementation on boar semen quality. Acta

Veterinaria Brno 76(4): 595-600.

  • Muller, D. M., H. Seim, et al. (2002). Effects of oral L-carnitine supplementation on in vivo long-chain fatty

acid oxidation in healthy adults. Metabolism: Clinical and Experimental 51(11): 1389-1391.

  • Orme, C. E., R. C. Harris, et al. (1995). Effect of elevated plasma FFA on fat utilisation during low intensity
  • exercise. Equine Vet. J Suppl. 18: 199-
  • 204.
  • Rivero, J. L., H. P. Sporleder, et al. (2002). Oral L-carnitine combined with training promotes changes in

skeletal muscle. Equine veterinary journal. Supplement(34): 269-274.

  • Souffleux, G. (1994). Benefit of using Rossovet carnitine for horses in preparation for amateur carriage-
  • racing. Pratique Veterinaire Equine
  • 26(4): 241-248.
  • Stradaioli, G., L. Sylla, et al. (2004). Effect of L-carnitine administration on the seminal characteristics of
  • ligoasthenospermic stallions.
  • Theriogenology 62(3-4): 761-777.
  • Stradaioli, G., L. Sylla, et al. (2000). Seminal carnitine and acetylcarnitine content and carnitine

acetyltransferase activity in young Maremmano stallions. Animal Reproduction Science 64(3/4): 233-245.

  • Van Weyenberg, S., J. Buyse, et al. (2009). Increased plasma leptin through
  • l-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies. Journal of

Animal Physiology and Animal Nutrition 93(2): 203-208.

Carnitol a specific formulation for horses

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