Carnitol Stimulate energy metabolism Optimize overall performances - - PowerPoint PPT Presentation

Carnitol

Stimulate energy metabolism Optimize overall performances of animals

11/2013 Page 2

A unique combination

• Carnitol is a unique combination of ingredients selected to

stimulate energy metabolism and to optimize overall performances

• f animals.

Carnitol, for improved hepatic functions

L-Carnitine Sorbitol Plant extracts Magnesium

11/2013 Page 3

Carnitine, a key ingredient

• Carnitine, derived from an amino acid, is

found in nearly all cells of the body.

• Carnitine is the generic term for a number of

compounds that include L-carnitine, acetyl-L- carnitine, and propionyl-L-carnitine.

• The D-form does not occur in nature but may

be obtained by chemical synthesis. The D isomer of carnitine is biologically inactive and it also hinders activities of L-carnitine.

Carnitol, for improved hepatic functions

11/2013 Page 4

L-Carnitine, a key ingredient

• Convert fat into energy.

– Improve energy metabolism and energy feed convertion

• Cardio-vascular system

– Heart energy comes mostly from fat and L-Carnitine

• Antioxidant support

– Serves as an antioxidant

• Maintaining muscle integrity

– provide blood flow to smooth muscles

Carnitol, for improved hepatic functions

11/2013 Page 5

L-Carnitine, a key ingredient

• Carnitine plays a critical role in energy production. It transports

long-chain fatty acids into the mitochondria so they can be oxidized ("burned") to produce energy.

Carnitol, for improved hepatic functions

11/2013 Page 6

L-Carnitine, other functions

• Buffering and removing of the potentially toxic

acyl groups from cells

• Regulate the ratios free CoA / acylCoA in 2

separate cellular compartments (cytosol and mitochondria)

• Regulate gluconeogenesis, fatty acid synthesis

and ketone bodies, branched chain amino acid, triglyceride and cholesterol metabolism

Carnitol, for improved hepatic functions

11/2013 Page 7

L-Carnitine, supplementary sources

• Carnitine occurs naturally in microorganisms, plants and animals.
• The major dietary sources are red meat, poultry, fish and dairy

products [59]. Animal meals contain 10 to 20 times more L- carnitine than plant-based feedstuffs.

Carnitol, for improved hepatic functions

11/2013 Page 8

L-Carnitine for animal health

• Because feedstuffs are mainly

composed by non-animal raw materials, it is useful to incorporate L-carnitine into diets to ensure that animals receive adequate amounts of L-carnitine.

Carnitol, for improved hepatic functions

• L-carnitine oral supplementation is recommended in case of

metabolic burdens such as exercise, heat or cold exposure or when energy demands are elevated (growth in young animals, high zootechnical performance or fat-enriched diet).

11/2013 Page 9

L-Carnitine, distribution

• L-carnitine oral supplementation can be

realised either in the drinking water or directly in the diet. Since this compound is easily dissolved in water, the drinking water is often preferred to achieve a homogeneous mixture.

Carnitol, for improved hepatic functions

11/2013 Page 10

Sorbitol, choleretic and cholagogue

• Sorbitol is especially indicated for its favorable effect on liver

metabolism.

• Sorbitol increases the secretion of digestive enzymes (pancreatic one)

and therefore promotes good digestion of feed and avoids fat

• verload by increasing the production of bile salt (choleretic and

cholagogue effect)

• Sorbitol acts as an osmotic substance and facilitates the elimination of

toxic products.

Carnitol, for improved hepatic functions

11/2013 Page 11

Magnesium

• Magnesium is the fourth most abundant

cation in the body and plays an important physiological role in many of its functions.

• Magnesium balance is maintained by

renal regulation of magnesium reabsorption.

• Magnesium has a key role in many

biological processes such as cellular energy metabolism, cell replication, and protein synthesis.

Carnitol, for improved hepatic functions

11/2013 Page 12

Plant extracts :

Artichock (Cynara scolymus)

• The active contituents of C. scolymus are

mainly flavonoids and caffeoylquinic acid

• These compounds have been proved to

have hepatoprotective activity, hypolipidemic effect, antioxidant capacity and anti-inflammatory properties

Carnitol, for improved hepatic functions

11/2013 Page 13

Plant extracts :

Gentiana (Gentiana lutea)

• The active principles are the bitter tasting

secoiridoid glycosides gentiopicrin and amarogentin.

• G. lutea is very popular as a stomachic as

well as a component in preparations showing beneficial effects in gall and liver diseases

Carnitol, for improved hepatic functions

11/2013 Page 14

Carnitol, for improved hepatic functions

Magnesium Energy metabolism Protein synthesis Plant extracts Hepatoprotective and digestive functions Sorbitol Encourages bile production and secretion Stimulates liver activity L-carnitine Transports long chain fatty acids Allows storage and release of fats in case of high energy needs

Energy metabolism improvement

11/2013 Page 15

Carnitol, for improved hepatic functions

Field trial (2006):

Effect of Carnitol on growth performances of broilers Materials and method.

• 360 birds d-1 old allocated into 2 groups (Control or Carnitol)
• Feed: standard broiler prestarter (0 to10 days), a starter (10 to 21

days), a grower “high-energy diet” 3280 kcal/kg (21 to 35 days- pellets) and a finisher (35 to 42 days-pellets).

• Treatment: Addition of Carnitol in drinking water at 1 ml/L on days

28, 29 and 30 for Carnitol group only.

11/2013 Page 16

Carnitol, for improved hepatic functions

Field trial (2006):

Effect of Carnitol on growth performances of broilers Results.

Carnitol supplemented in drinking water on broilers fed with high energy diet improves growth performance by increasing body weight gain and FCR.

11/2013 Page 17

Carnitol, for improved hepatic functions

Carnitol, main targets

• Reduction of fatty liver syndrome
• Optimized energetic metabolism
• Improve fat digestibility
• Improved production performances

11/2013 Page 18

Carnitol, for improved hepatic functions

Carnitol, advance formulation

• L-carnitine : 60 000 mg/L
• Sorbitol syrup : 250 000 mg/L
• Magnesium : 20 000 mg/L
• Plant extracts : Cynara scolymus

and Gentiana lutea

11/2013 Page 19

Carnitol, for improved hepatic functions

Direction for use

• Poultry, swine: 1ml/L of drinking water for 3 to 5 days
• Cattle, camels, horses: 20 ml/100kg body weight per day.
• Sheep, goats, calves: 4 ml/10 kg body weight per day.