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Ph.D., LL.M., F-ABFT, FCSFS Forensic Toxicologist, Chemical Review Services Inc. Adjunct Professor, Forensic Science University of Ontario Institute of Technology
Cannabis – Some Challenges with Determining Impairment - A Forensic Toxicologist’s Perspective.
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Illuminating the Field – Forensic Toxicology
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Illuminating the Field – Cannabis
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Casarett & Doull’s Toxicology
SLIDE 5 Toxicology – Definition - Academic
Toxicology has been defined as the study of the
adverse effects of xenobiotics …
Toxicology, like medicine, is both a science and an
- art. The science of toxicology is defined as the
- bservational and data gathering phase, whereas the
art of toxicology consists of the utilization of the data to predict outcomes of exposure in human and animal populations.
Gallo, M.A. (2013). History and Scope of Toxicology. In C.D. Klaassen (ed.), Casarett & Doull’s Toxicology: The Basic Science of Poisons, 8th ed. Toronto: McGraw Hill. (p.3.)
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Society of Toxicology
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Toxicology – Definition - SOT
The study of the adverse effects of chemical,
physical or biological agents on people, animals, and the environment.
SLIDE 8 SOT – Specialty Sections
27 speciality sections
One of them is entitled Ethical, Legal, and Social Issues
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Society of Forensic Toxicologists - SOFT
SLIDE 10 Forensic Toxicology – Definition - SOFT
Toxicology is the study of the adverse effects of
drugs and chemicals
biological systems. Forensic toxicology deals with the application of toxicology to cases and issues where those adverse effects have administrative
medicolegal consequences, and where the results are likely to be used in court. Forensic toxicology is a modern science, based on published and widely accepted scientific methods and practices, for both analysis of drugs in biological materials, and interpretation of those results.
http://www.soft-tox.org/files/SOFT_Brochure_(2013).pdf
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Alcohol – A Drug with Distinction
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American Board of Forensic Toxicology - ABFT
SLIDE 13 Forensic Toxicology – Definition - ABFT
Forensic toxicology encompasses the measurement
- f alcohol, drugs and other toxic substances in
biological specimens and interpretation
such results in a medicolegal context. (current)
The study and practice of the application of
toxicology to the purposes of the law. (prior)
http://www.abft.org/
SLIDE 14 Toxicology – Specialized Science
A specialized science of the adverse effects of
chemicals on biological subjects (eg. people).
Ethanol Drugs Chemicals Biotoxins Above terms are not mutually exclusive
SLIDE 15 Forensic Toxicology - Specialties
Postmortem Human Performance Employment / Applicant (eg. Insurance) Athletic Competition Equine Environmental
overlap with some other fields Occupational Medicine Medical Toxicology Epidemiology
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Drug Testing – Some Considerations
Specimens Application: Clinical or Forensic Nature: Screening or Confirmation Result: Qualitative or Quantitative Use: Investigative Aid or Evidence
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SLIDE 18 Routes of Flow of Chemicals in the Body
[Casarett & Doull’s Toxicology, p.154.]
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Immunoassay (IA)
Urine – Clin / For – Screening – Qualitative – Investigative Aid
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Gas Chromatography with Mass Spectrometry (GC-MS)
Urine – Forensic – Confirmation – Quantitative - Evidence
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Challenges with Determining Impairment – Times
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Challenge 1: Time of Specimen Collection
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Marijuana and the Cannabinoids
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PL Concentrations After Smoking Cannabis
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Challenge 2 – Time of Use
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I Don’t Know
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Challenge 3: Relating Test Result to Time of Incident
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Human Growth and Development
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Cannabis – Selected Psychoactive Effects
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THC – Individual Subject Effects - High
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Host Factors - Drug Response
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Illuminating – Cannabis – Wake n’ Bake
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Challenge 4: Time of Retainer
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Expert Evidence
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CLE – Interaction with Experts
The expert’s opinion must be and must be seen
to be detached and independent.
Counsel must be fair in ensuring that the expert
has proper material to formulate an opinion.
[Lauwers J., “Comments on Expert Evidence”, in Expert Reports at 8. (Paper presented to the MLST, 23 January 2012)]
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CLE – Experts & Documents
Experts must ensure that they obtain all of the
necessary documents and review them with a critical eye, rather than simply accepting information from a litigant.
[Troy H. Lehman, in Expert Evidence in Personal Injury Cases at 23. (Paper presented to Osgoode Prof. Develop., 2 April 2012)]
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Expert & Counsel – Attempting to Walk on Water
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Finishing Time