SLIDE 10 Boot Camp 2015 3/5/15 NAACCR 2014-2015 Webinar Series 10
HE R2 T E ST ING
- Recommendations for Human Epidermal Growth Factor
2 Testing in Breast Cancer
- http://www.cap.org/apps/cap.Portal?_nfpb=true&cntvwrPtlt
_actionOverride=%2Fportlets%2FcontentViewer%2Fshow&cnt vwrPtlt%7BactionForm.contentReference%7D=committees%2 Fimmunohistochemistry%2Fher2_index.html&_pageLabel=cnt vwr
- ASCO–CAP HER2 Test Guideline Recommendations
- Summary of Recommendations
- http://www.cap.org/apps/cap.Portal?_nfpb=true&cntvwrP
tlt_actionOverride=%2Fportlets%2FcontentViewer%2Fshow& cntvwrPtlt%7BactionForm.contentReference%7D=committe es%2Fimmunohistochemistry%2Fher2_index.html&_pageLab el=cntvwr
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2013 RE COMME NDAT ION
- Report HER2 test result positive
- IHC 3+ based on circumferential membrane staining
that is complete, intense
- ISH positive based on:
- Single-probe average HER2 copy number ≥6.0 signals/cell
- Dual-probe HER2/CEP17 ratio ≥2.0; with an average HER2
copy number ≥4.0 signals/cell
- Dual-probe HER2/CEP17 ratio ≥2.0; with an average HER2
copy number <4.0 signals/cell
- Dual-probe HER2/CEP17 ratio < 2.0; with an average HER2
copy number ≥6.0 signals/cell
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E XAMPL E
- HER2 FISH test result: Ratio of 1.52; average
copy number 6.0 signals/cell; elevated HER2
- What is the code for CS SSF10 (FISH Lab
Value)?
- What is the code for CS SSF11(HER2: FISH Test
Interpretation)?
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