ARMOR Optimize Chad Byers - Project Manager Brendan Grebur - Domain - - PowerPoint PPT Presentation

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Nov 15, 2023 330 likes •500 views

ARMOR Optimize Chad Byers - Project Manager Brendan Grebur - Domain Expert / Customer Liaison Rory Hool - Project Facilitator Caitlin Russ - Artifacts Manager What Optimization Means Finding solution(s) to maximize / minimize a set of defined

SLIDE 1

ARMOR Optimize

Chad Byers - Project Manager Brendan Grebur - Domain Expert / Customer Liaison Rory Hool - Project Facilitator Caitlin Russ - Artifacts Manager

SLIDE 2

What Optimization Means

Finding solution(s) to maximize / minimize a set of defined criteria, subject

to a set of constraints, for a specific problem

Problem
Improving a patient's quality of life by reducing polypharmacy

interactions

Criteria
Increasing or Reducing
Bodily aspects (appetite, balance, vision, etc.)
Constraints
Drug constraints

§ Increase / Reduce / Remove / No Alteration

Condition constraints

§ "To treat or not to treat"

SLIDE 3

The Basic Terminology

Continuity of Care Record (CCR)
Body Measurements
Afflicting Conditions
Drugs (Past / Present)
Drugs
Prescribed and Over-the-counter (OTC)
Frequency and Dosage
Set of affected body aspects and a quantitative effect
Increase or Decrease
Condition
Treated by a group of drugs
Body Aspect
Similar to side effects
Appetite, vision, balance, depression, diarrhea
Treatment Plan
Current: Existing prescribed treatment plan
Recommended: Optimized treatment plans for review

SLIDE 4

The Extended Terminology

Goal Profile
A collection of:
Body aspects each denoting a desired change
Other Goal Profiles
Example:
Better Balance { vision+ , dizziness- , lightheaded- }
Goal Set
An accumulation of weighted:
Goal profiles
Individual body aspects each with denoted change
Example:
(5 * Better Balance ) + (3 * depression-)

SLIDE 5

Use Case Diagram

SLIDE 6

Web Interface Front-end Class Diagram

SLIDE 7

System Back (Server) - Evolutionary Computation

Modification Encoding
Representation of adjustments to current treatment plan
Treatment Adjustment ("Gene")
Per drug containing:
Increase / Decrease / Reduce / No Alteration
Population
Encodings competing to provide the best solution
Selection Protocol
Roulette
Tournament*
Rank

SLIDE 8

Evolutionary Computation Back-end Class Diagram

SLIDE 9

Evolutionary Optimization Algorithm

SLIDE 10

System Front (Client) Statechart

SLIDE 11

System Back (Server) Statechart

SLIDE 12

Sequence Diagram: Creating And Using New Goal Profile

SLIDE 13

Sequence Diagram: Evolutionary Optimization

SLIDE 14

Sequence Diagram:

Display and Review of Treatment Plans

SLIDE 15

Sequence Diagram: Goals Not Specified for Optimization

SLIDE 16

Prototype Demo

High Level Features of User Interface
Upload CCR with Analysis Results
Select drug / condition constraints
Create custom Goal Profile
Select Goal Profiles and Body Aspects for Goal Set
Select Weighting Criteria for members of Goal Set
View Optimization summary
View Optimized treatment plans
Save / Delete treatment plans