Aris Floratos (Flash talk) & Kenneth Smith (Demo) Columbia - PowerPoint PPT Presentation

Jul 27, 2023 •243 likes •320 views

Aris Floratos (Flash talk) & Kenneth Smith (Demo) Columbia University MAGNet : National Center for the Multiscale Analysis of Genomic and Cellular Networks: http://magnet.c2b2.columbia.edu Integrated access to MAGNet Center and 3rd party tools.

Aris Floratos (Flash talk) & Kenneth Smith (Demo) Columbia University
MAGNet : National Center for the Multiscale Analysis of Genomic and Cellular Networks: http://magnet.c2b2.columbia.edu Integrated access to MAGNet Center and 3rd party tools. Java, open source, extensible platform. 70+ analytical and visualization modules. http://www.geworkbench.org
3 new geWorkbench modules (data and tools from Andrea Califano’s lab @ Columbia) : Querying interface for computational LINCS Drug synergy predictions and experimental Synergy Data validation assays (Mariano Alvarez) Virtual Inference of Protein-activity VIPER by Regulon Readout (Mariano Alvarez) Drug Mechanism of Action using DeMAND Network Dysregulation (Yishai Shimoni)
Step 1 : Interactome construction. ARACNe Public GE data Step 2 : Identification of differentially expressed genes. Vs. Differentially expressed genes LINCS Cell Line LINCS Cell Line (untreated) (Drug D treated)
Step 3 : Inference of drug functional mechanism of action. G1 G2 G3 fMoA (Drug D) = {G1, G2, G3}
geWorkbench dev team Califano Lab • Kenneth Smith • Andrea Califano • Zhou Ji • Mariano Alvarez • Meng Wang • Mukesh Bansal • Min You • Gabrielle Rieckhof • Michael Honig National Centers for Biomedical Computing

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