ANALYTICAL CHEMISTRY Philip.Doble@uts.edu.au School of Mathematical - - PowerPoint PPT Presentation

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ANALYTICAL CHEMISTRY Philip.Doble@uts.edu.au School of Mathematical - - PowerPoint PPT Presentation

Apr 03, 2024 530 likes •661 views

ANALYTICAL CHEMISTRY Philip.Doble@uts.edu.au School of Mathematical and Physical Sciences UTS:SCIENCE UTS CRICOS PROVIDER CODE: 00099F science.uts.edu.au CORE CAPABILITIES Inductively Coupled Plasma - Mass Spectrometry (ICP-MS)

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UTS CRICOS PROVIDER CODE: 00099F

UTS:SCIENCE School of Mathematical and Physical Sciences

ANALYTICAL CHEMISTRY

science.uts.edu.au

Philip.Doble@uts.edu.au

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CORE CAPABILITIES

  • Inductively Coupled Plasma - Mass Spectrometry (ICP-MS)
  • Laser Ablation (LA)
  • High Performance Liquid Chromatography (HPLC)
  • Gas Chromatography (GC)
  • Ion Chromatography (IC)
  • LOC on a Chip (LOC)
  • DNA Analysers
  • Micro Paper Analytical Devices (uPADs)
  • Tandem Mass Spectrometry
  • Triple Quad (QqQ)
  • Quadrupole Time of Flight (QTOF)

science.uts.edu.au

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CORE CAPABILITIES

  • Hyphenated Techniques
  • HPLC-QqQ
  • HPLC-QTOF
  • LA-ICP-MS
  • IC-MS
  • GC-MS
  • Automated Sample Preparation
  • EPREP

science.uts.edu.au

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IMAGING MASS SPECTROMETRY

  • Laser Ablation – Inductively Coupled Plasma – Mass

Spectrometry

  • Applications
  • Analysis of elements in neurodegenerative disorders
  • Analysis of proteins
  • Three dimensional reconstructions of mouse neuroanatomy
  • Cancer diagnosis
  • Endogenous metals in teeth and brains, etc.

science.uts.edu.au

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VISUALISING MOUSE NEUROANATOMY

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Hippocampus Zn > 5 Compacta, Fe >20, Yb > 5000 cps Reticulata, Fe > 40 mg /kg

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THERMO FISHER WATER SECURITY POC LABS

  • Established May 2016
  • Equipped with latest separation science and mass spectrometry

instrumentation

  • A state of the art facility to undertake proof of concepts for the analysis of

water

  • Train PhDs (including industry doctorates)
  • Interact with industry partners (including internships)
  • Undertake short and long term priority projects
  • Be responsive to emerging water security issues

science.uts.edu.au

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WATER SECURITY POC LABS

  • Non targeted LC-MS analysis of polyfluoroalkyl substances
  • Perfluroalkyl and poly- fluoroalkyl substances (FPAS) have been used

since the 1950’s as surfactants and protectors for a plethora of industrial, commercial and consumer product applications.

  • FPAS are of increasing environmental concern as they are highly

persistent with significant bio-accumulation potential.

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EPREP

  • Developed as an affordable solution to preparing samples prior to analysis

in any laboratory

  • High pressure SPE
  • Faster and more efficient sample prep to reduce cost of analysis
  • UTS will develop methods for the automated sample preparation of

important classes of chemicals

  • EPREP co-funds PhD students
  • Initial target are EPA methods of solid phase

extraction

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WATER SECURITY POC LABS AND EPREP

  • Application development and validation of automated micro solid phase

extraction applications

  • This UTS-EPREP industry based PhD projects aims to investigate the

capabilities of the automated solid phase extraction sample preparation instrument, and its application to high profile and important analyses performed in Australia.

  • Phthalate Esters
  • Organochlorine pesticides
  • Polychlorinated biphenyls
  • Organophosphorus pesticides
  • Nitroaromatics and nitramines
  • TCLP leachates containing semi-volatiles

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  • Customisable micro solid phase extraction applications
  • This UTS-EPREP industry based PhD projects aim to investigate the

methods of binding ligands to customisable generic substrates for targeted sample preparation for samples of biological and environmental significance.

  • The customised stationary phases will be incorporated into the EPREP

automated SPE system to improve sample preparation specificity, simplicity and functionality for analysis by mass spectrometry techniques.

  • Potential ligands include antibodies, crytpands, functionalised

surfactants, and aptamers.

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WATER SECURITY POC LABS AND EPREP

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Bubble-in-drop single drop microextraction

  • Improves over SDME
  • 2-4x for triazines (water and soil samples)
  • 1.5-2x for organochlorine pesticides (natural water

samples)

  • 1.5-2x for synthetic growth hormones (bovine urine)
  • Potential for drugs, environmental analysis

Solvent-assisted headspace analysis

  • Improves over HS-SPME
  • 1-2 orders of magnitude for chlorophenols
  • Broad potential for application
  • Short fibre lifetime – current research

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WATER SECURITY – MICROEXTRACTION

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CONTACTS

Philip.Doble@uts.edu.au (https://www.uts.edu.au/staff/philip.doble) Analytical chemistry, organic and inorganic analyses, application development and validation Bradley.Williams@uts.edu.au (https://www.uts.edu.au/staff/bradley.williams) Analytical micro-extraction techniques, organic synthesis, homogeneous catalysis, Lewis acid catalysis Nerida.Cole@uts.edu.au (https://www.uts.edu.au/staff/nerida.cole) LA-ICP-MS, immunohistochemistry, method development and validation David.Bishop@uts.edu.au (https://www.uts.edu.au/staff/david.bishop) LA-ICP-MS, LC-MS, GC-MS and method development Lucas.Blanes@uts.edu.au (https://www.uts.edu.au/staff/lucas.blanes) Lab-on-chip, uPADS, and explosives detection

science.uts.edu.au