Adolescent Depression (PI: Gunlicks-Stoessel) First-stage - - PowerPoint PPT Presentation

R IPT-A for 4 weeks

Sufficient Response Insufficient Response

Add Fluoxetine Increase IPT-A Dose Continue IPT-A IPT-A for 8 weeks

R R

A Subgroups B C D E F Study and IPT-A Treatment Begin Week 8 Week 32 Study Ends

Experimental Conditions Second-stage intervention Intermediate

• utcome

First-stage intervention

Week 16 Treatment Ends Add Fluoxetine Increase IPT-A Dose Continue IPT-A Week 4

Insufficient Response Sufficient Response

IPT-Aà Interpersonal Psychotherapy for Depressed Adolescents Fluoxetine à medication for depression; also known as Prozac Week 4 Insufficient Response à <20% reduction in depressive sx Week 8 Insufficient Response à <40% reduction in depressive sx

Adolescent Depression (PI: Gunlicks-Stoessel)

R JASPER + EMT JASPER + EMT + SGD Intensified JASPER + EMT

Early Response Slow Response

JASPER + EMT Intensified JASPER + EMT + SGD JASPER + EMT + SGD JASPER + EMT + SGD

R

A Subgroups B C D E Study and Treatment Begin Week 12 Month 6

Experimental Conditions Second-stage intervention Intermediate

• utcome

First-stage intervention

Early Response Slow Response

JASPER à Joint Attention and joint Engagement EMT à Enhanced Milieu Teaching SGD à Speech Generating Device (e.g., an iPad or Dynavox) Early Response à 25%+ improvement on 7+ communication measures

Autism (PI: Kasari)

R MED + Monitoring

Response Non- Response

Intensify MED Augment (MED+BMOD)

Response Non- Response

Continue Intensify BMOD Augment (BMOD+MED) Continue BMOD + Monitoring

R R

A Subgroups B C D E F Beginning of school year Monthly, starting at Week 8 End of school year

Experimental Conditions Second-stage intervention Intermediate

• utcome

First-stage intervention

MEDà Low-dose methylphenidate (am) Intensify MEDà Higher-dose or add pm

BMODà Behavioral Modification Intensify BMODà Intensify/add components

Non-responseà Teacher-rated Individualized Target Behavior Evals < 75% and

Teacher-rated Impairment Rating Scale > 3 on at least one domain

Child ADHD (PI: Pelham)