Accurate Regression Parameters and Summary Statistics Estimation - - PowerPoint PPT Presentation

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accurate regression parameters and summary statistics
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Accurate Regression Parameters and Summary Statistics Estimation - - PowerPoint PPT Presentation

Jan 18, 2023 359 likes •533 views

Accurate Regression Parameters and Summary Statistics Estimation in Data with Censored Missing Values Yuliya Karpievitch Imputation And Censored Values Yuliya Karpievitch Missing Values and Imputation Some algorithms expect a

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Yuliya Karpievitch

Accurate Regression Parameters and Summary Statistics Estimation in Data with Censored Missing Values

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Yuliya Karpievitch

Imputation And Censored Values

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Missing Values and Imputation

  • Some algorithms expect a ‘complete’ matrix
  • Differential Expression Analysis is affected by

missing values

  • Censored values are lower than the observed ones
  • Simple imputation methods are not good enough
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Example Protein

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Simple Imputation – Detection Limit

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Simple Imputation - Mean

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Model-based Imputation

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ROC Curve for Numerical Estimation

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Half of the Detection Limit

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NORM

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NORM Squeezed

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Estimating Regression Coefficients

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Estimating the Mean

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Collaborators: Firouzeh Noghrehchi John McKinlay