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Accessible version: https://youtu.be/Z80AgLojsy0
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Accessible version: https://youtu.be/Z80AgLojsy0 - - PowerPoint PPT Presentation
Accessible version: https://youtu.be/Z80AgLojsy0 - - PowerPoint PPT Presentation
Accessible version: https://youtu.be/Z80AgLojsy0 Persistent infection with high-risk types required for progression to
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Persistent infection with high-risk types required for progression to precancer and cancer Peak incidence of precancers in late 20’s and of cancers in mid to late 40’s
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Oropharynx
Average Number of New HPV-associated Cancers Overall, and by Sex, in the United States, 2005-2009
n=694 n=4771 n=1003 n=3039 n=694 n=3039 n=2317 n=3084 n=11279 n=9312 n=1687 n=1003
*In addition: Cervical disease and pre-invasive cancers: CIN1,2,3~ 1.4 million;
AIN3~4300; VIN3~27,000,VAIN3~7600 (CDC, unpublished data)
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Y axis scale is different for cervical cancer.
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0.2
- 2.5
- 0.3
1.7 0.8 4.9 1.0
- 1.6
3.9
Hispanic AI/AN API Black White
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1 2 3 4 5 6 7 8 9
Males Females
Oropharynx 0.7 1.6 2.5 3.7 0.9 2.1 5.6 2.6
Hispanic AI/AN API Black White
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Anus
* * * * * * *
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HPV attributable cancers = 26,000 cancers HPV 16/18 attributable cancers= 21,000 cancers
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2006 2007 2008 2009 2010 2011 2012
June October October
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2 4 6 8 10 12 14 16 18 Proportion with genital warts % Half year Resident women
73% decrease in genital warts Vaccine first introduced in Australia in 2006 (dashed line)
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Tdap MCV4 >1 dose HPV (girls) 3 doses HPV (girls)
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Alabama Arizona Arkansas California Colorado
Connecticut
Delaware Florida Georgia Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada
N e w H a m ps hire
New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Rhode Island South Carolina South Dakota Tennessee Texas Utah
V e rm
- nt
Virginia Washington West Virginia Wisconsin Wyoming
Alaska Hawaii Alaska
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Percent
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Response categories are not mutually exclusive
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Among girls unvaccinated for HPV, 78% had a missed opportunity
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booster 3-dose series 1st dose Annual immunization 1 dose
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Percent
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*p<0.05 Vaccine
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Age-standardized incidence
(per 100 000 women/year) 42 to 60 (12) 39 to 42 (4) 36 to 39 (4) 33 to 36 (9) 30 to 33 (6) 27 to 30 (14) 24 to 27 (9) 21 to 24 (12) 18 to 21 (12) 15 to 18 (20) 12 to 15 (16) 9 to 12 (19) 6 to 9 (23) 3 to 6 (16) 0 to 3 (6)
80% of cervical cancer deaths occur in developing countries
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No (150 countries or 77%) Yes (40 countries or 21%) Yes (Part of the country) (4 countries or 2%)
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