A Comparison of EIT Lung Perfusion Measures Symon Stowe 1 , Alistair - PowerPoint PPT Presentation

A Comparison of EIT Lung Perfusion Measures Symon Stowe 1 , Alistair Boyle 1 , Michaël Sage 2 , Mathieu Nadeau 2 , Jean-Paul Praud 2 , É@enne For@n-Pellerin 2 , Andy Adler 1 1 Carleton University, OFawa, Canada, 2 Université de Sherbrooke, Canada symon.stowe@carleton.ca A Comparison of EIT Lung Perfusion Measures, 1 Symon Stowe, 2018/06/11

Why Monitor Lung Perfusion? • Pulmonary embolisms are notoriously challenging to diagnose and monitor • Mainly diagnosed using CT pulmonary angiography • Associated with radia:on exposure and invasive administra:on of a contrast agent • Clinical need to improve diagnosis and monitoring • Safe and low-cost method with few false posi:ves A Comparison of EIT Lung Perfusion Measures, 2 Symon Stowe, 2018/06/11

Perfusion/Ven,la,on Monitoring Perfusion/Ven,la,on match Perfusion/Ven,la,on mismatch Sample sketches represent ven;la;on and perfusion in a human thorax A Comparison of EIT Lung Perfusion Measures, 3 Symon Stowe, 2018/06/11

Ventilation Perfusion • Less understood and validated • Validated and reasonably well understood A Comparison of EIT Lung Perfusion Measures, 4 Symon Stowe, 2018/06/11

Perfusion Monitoring Techniques A Comparison of EIT Lung Perfusion Measures, 5 Symon Stowe, 2018/06/11

Contrast agent measures of perfusion • Requires apnoea • Non-con0nuous • Invasive • Can be performed a limited number of 0mes • Provides a series of blood flow images A Comparison of EIT Lung Perfusion Measures, 6 Symon Stowe, 2018/06/11

A Comparison of EIT Lung Perfusion Measures, 7 Symon Stowe, 2018/06/11

A Comparison of EIT Lung Perfusion Measures, 8 Symon Stowe, 2018/06/11

A Comparison of EIT Lung Perfusion Measures, 9 Symon Stowe, 2018/06/11

Experimental Protocol A Comparison of EIT Lung Perfusion Measures, 10 Symon Stowe, 2018/06/11

Experimental Protocol A Comparison of EIT Lung Perfusion Measures, 11 Symon Stowe, 2018/06/11

Pulsa&lity Analysis A Comparison of EIT Lung Perfusion Measures, 12 Symon Stowe, 2018/06/11

Frequency filtering technique A Comparison of EIT Lung Perfusion Measures, 13 Symon Stowe, 2018/06/11

Shortcomings of Pulsa2lity • Heart rate is unstable over time • Many pixels throughout the image are out of phase • Events at the heart rate frequency are not limited to perfusion A Comparison of EIT Lung Perfusion Measures, 14 Symon Stowe, 2018/06/11

Conclusion • Many challenges accurately es/ma/ng perfusion from pulsa/lity • Preliminary analysis shows correla/on between the three methods of perfusion measures • Comparing both center of mass and overall shape A Comparison of EIT Lung Perfusion Measures, 15 Symon Stowe, 2018/06/11

A Comparison of EIT Lung Perfusion Measures Symon Stowe 1 , Alistair Boyle 1 , Michaël Sage 2 , Mathieu Nadeau 2 , Jean-Paul Praud 2 , É@enne For@n-Pellerin 2 , Andy Adler 1 1 Carleton University, OFawa, Canada, 2 Université de Sherbrooke, Canada symon.stowe@carleton.ca A Comparison of EIT Lung Perfusion Measures, 16 Symon Stowe, 2018/06/11