A A New Appr Approach h to to HAI Challenges Pathogens are a - - PowerPoint PPT Presentation

A A New Appr Approach h to to HAI Challenges

A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM

Pathogens are a deadly problem

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1: Economic burden of healthcare-associated infections: an American perspective, Patricia W Stone, PhD, FAAN, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827870/ 2: https://www.cdc.gov/hai/surveillance/index.html

90,000

Nearly 90,000 are estimated to die.1

$28 Billion

Direct costs of HAIs ranges: US $28 billion to 45 billion

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On any given day, about one in 25 hospital patients has at least one healthcare- associated infection.2

2 million

Approximately 2 million patients suffer with healthcare- associated infections (HAIs) in the USA.1

A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM

Conventional (low-pressure) UV Expensive, hot, cumbersome, disruptive

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Chemical Disinfectants (bleach, chlorahexidine) Heat (autoclave) Physical (scrubbing) Labor-intensive, time-consuming, skill-dependent, potentially toxic Time-consuming, expensive, not applicable to every surface Labor-intensive, time-consuming, skill-dependent

“No clear, superior device/method at this time.” 1

David Weber, M.D., M.P.H., Associate Chief Medical Officer, UNC Hospitals

1 As presented at APIC 2018 Minneapolis, MN

Antibiotics Decreasing effectiveness, expensive, side- effects

A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM

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Competitors’ low pressure UV technology

mW cm2

Low power: ~32

Conventional (low-pressure) UV Expensive, hot, cumbersome, disruptive

Single wavelength

ULTRAVIOLET VISIBLE INFRARED Wavelength (nm)

A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM

A new weapon: High-intensity photonics

We are advancing the current state of photonics to improve

• ur ability to inactivate viruses,

bacteria and mold.

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Based on physics (of DNA replication), not chemistry or biology (of cell walls).

A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM

The power of high-intensity photonics

Manage multiple wavelengths

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222 253.7 365 405

High energy density

mW cm2

>1000

ULTRAVIOLET VISIBLE INFRARED Wavelength (nm)

A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM

Hyper Light is effective

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1.0 E+13 1.0 E+12 1.0 E+11 1.0 E+10 1.0 E+09 1.0 E+08 1.0 E+07 1.0 E+06 1.0 E+05 1.0 E+04 1.0 E+03 1.0 E+02 1.0 E+01 1.0 E+00

• S. Aureus

(e.g., MRSA)

• A. brasiliesis

(black mold)

• P. aeruginosa
• S. pseudintermedius

VRE

• E. faecalis

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5 sec. 25 sec. 5 sec. 25 sec. 25 sec. 25 sec. Exposure

PFU

EMSL Analytical Laboratory, Research Triangle Park, NC. Data collected 12/2017…6/2018

• C. diff*

75 sec.

• E. coli

25 sec.

*Preliminary results, pending final report from Microbac Laboratory, Sterling VA. Data collected 6/2018

Before exposure After exposure

• ~

A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM

Hyper Light is cool

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80 78 76 74 72 70 68 66 64 62 60

300 600

Temp. (°F)

EMSL Analytical Laboratory, Research Triangle Park, NC. Data collected 12/2017…6/2018

100

Exposure (seconds)

• S. pseudintermedius

VRE

• S. aureus

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• A. brasiliensis
• E. faecalis
• E. coli

I I

A NEW APPROACH TO HAI CHALLENGES / CONFIDENTIAL / WWW.HPLIGHT.COM

The power of Hyper Light

• Inactivates pathogens
• Fast
• Enhances the power, efficacy and usability of UV light
• Fits into health care workflows
• Superior photonics: Intense, controlled
• Superior optics: Precisely focused and amplified
• Superior delivery: Precise hand-held delivery
• Cool (ambient temperatures)
• Patented
• Reduces HAIs

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