- 2,3*%4!5%6!27 ( %7, ( 8 !)4%498!9%* (4 )$4)&)76%6!27 ( 2+ (( - - PowerPoint PPT Presentation

▶
2 3 4 5 6 27 7 8 4i8 9 4 4 76 6 27 2 2 2 93 4 7 6 24
SMART_READER_LITE
LIVE PREVIEW

- 2,3*%4!5%6!27 ( %7, ( 8 !)4%498!9%* (4 )$4)&)76%6!27 ( 2+ (( - - PowerPoint PPT Presentation

Jan 16, 2024 26 likes •676 views

!"#$%&'(" !)*)+)*, (- %. (/010 !"#$#%&'()*'#+,-.-/& - 2,3*%4!5%6!27 ( %7, ( 8 !)4%498!9%* (4 )$4)&)76%6!27 ( 2+ (( " !2-2*)93*%4 (7 )6:24;& (( :!68 ($ )64! (7 )6& (6 4%7&!6!27 (! 7<%4!%76&

slide-1
SLIDE 1

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

!"#$%&'("!)*)+)*,(-%.(/010

  • 2,3*%4!5%6!27(%7,(

8!)4%498!9%*(4)$4)&)76%6!27(2+(( "!2-2*)93*%4(7)6:24;&((

:!68($)64!(7)6&(64%7&!6!27(!7<%4!%76&

  • =>?@A(8B?>BC

"CA>DB>EFCG(3>?HBCI?JK(=L(6BMN>=O=GK(9=JJEFI ,BPJQ(=L(9&

slide-2
SLIDE 2

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

+4%-):24;R(&.&6)-&("!2*2S.

!"#$%$&'( )*&+,*- (#.'- #!$',/'. !'0*/"#+, 1,'."2&'. !'0*/"#+, A)(.2;# *-<).9;2')<# )BC)5,*)0(#<)',/0 )BC)5,*)0(' 7-5*2.,D,0/# 80<)5'(20<,0/ A)(.2;# )BC)5,*)0('

  • 2,)**!7S((((T(((((+24-%*(;72:*),S)(4)$4)&)76%6!27
slide-3
SLIDE 3

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

+4%-):24;R(&.&6)-&("!2*2S.

!"#$%$&'( )*&+,*- (#.'- #!$',/'. !'0*/"#+, 1,'."2&'. !'0*/"#+, A)(.2;# *-<).9;2')<# )BC)5,*)0(#<)',/0 )BC)5,*)0(' 7-5*2.,D,0/# 80<)5'(20<,0/ A)(.2;# )BC)5,*)0(' (#.'-3 /*-".*&"#)

  • 2,)**!7S((((T(((((+24-%*(;72:*),S)(4)$4)&)76%6!27
  • 2,)*(<%*!,%6!27((((T((((927+!,)79)(!794)%&)(
slide-4
SLIDE 4

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

&6439634)(2+(68)(6%*;

! :NAJ(ACB(E?=MNBU?MAOOK(?>JBCPCBJBD($BJC?(>BJI(V ! :NAJ(ACB(6#?>HAC?A>JI(V 9E ,0()5C5)(2(,-0' 9E 7-5*2.#<)7,0,(,-0 ! -=DFOAC?WAJ?=>(A>D(N?BCACMN?MAO(CBPCBIB>JAJ?=>(FI?>G(6#?>HAC?A>JI 9E 2;'(52:(#<)C)0<)0(#(520',(,-0#')('#<)7,0)#.-/,:2.#;8,.<,0/#;.-:1' ! &=UB(APPO?MAJ?=>I 9E /.&:-.&','# 9E 2C-C(-',' 9E# 4&C-B,2# #9E C-(2(-#(8;)5 ! &FUUACK 9E C5-'#$#:-0'

slide-5
SLIDE 5

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

:8%6(%4)(

"!298)-!9%**.(!76)4$4)6),(

$)64!(7)6&V

slide-6
SLIDE 6

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

"!2($)64!(7)6&'()X1

(

5@F#####G#9E#>#+# 5>F##>#G#9E#H#I

slide-7
SLIDE 7

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

"!2($)64!(7)6&'()X1

( 4 5 ,4 ,6 7 8 9

5@F#####G#9E#>#+#

4

5>F##>#G#9E#H#I

slide-8
SLIDE 8

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

"!2($)64!(7)6&'()X1

( 4 5 ,4 ,6 7 8 9

5@F#####G#9E#>#+#

4 4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9 4

5>F##>#G#9E#H#I

slide-9
SLIDE 9

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

64%7&!6!27(!7<%4!%76&' %(94%&8(9234&)

slide-10
SLIDE 10

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

64%7&!6!27(!7<%4!%76&' %(94%&8(9234&)

!"#$%$&$'()*+#,%-.#&/0$1

slide-11
SLIDE 11

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X1

( 4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9

1 1 /

6#!7<%4!%76(1 6#!7<%4!%76(/

5@F####G#9E#>#+#

4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9

/ 1 Y

4 4

5>F#>#G#9E#H#I

slide-12
SLIDE 12

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

!79!,)79)(-%64!X(9

! A(CBPCBIB>JAJ?=>(=L(JNB(>BJ(IJCFMJFCB TZ(IJ=?MN?=UBJC?M(UAJC?[ ! UAJC?[(B>JCK(2";R J=@B>(MNA>GB(?>(POAMB(P?(EK(L?C?>G(=L(JCA>I?J?=>(J\( ! UAJC?[(M=OFU>(&;R HBMJ=C(DBIMC?E?>G(JNB(MNA>GB(=L(JNB(]N=OB(UAC@?>G(EK(L?C?>G(=L(J\ ! I?DB#M=>D?J?=>I(ACB(>BGOBMJBD

< = &6 &; &( 16 1" 1)

2";

:,J#K#LC,M#(JN#K#OL(JMC,N#9#OLC,M#(JN#K##(JLC,N

> > > > > > > > >

I3?

3 &;3 (J#K##(JLPN3

')@%(' ! * ')@%('A2*&*-%$'.3 ,'*2&"#) B B

M?\(T(0 \ ?

slide-13
SLIDE 13

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

!79!,)79)(-%64!X(9'()X1

( 4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9 4

slide-14
SLIDE 14

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

!79!,)79)(-%64!X(9'()X1

( 4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9 4 9 8 7 ,6 ,4 1,#.:9 2#)$:8 2#)$:7 < =

slide-15
SLIDE 15

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

!79!,)79)(-%64!X(9'()X1

( 4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9 4 9 8 7 ,6 ,4 1,#.:9 2#)$:8 2#)$:7 < = A6 4 A4 5 6 A6 A6

slide-16
SLIDE 16

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

!79!,)79)(-%64!X(9'()X1

( 4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9 4 9 8 7 ,6 ,4 1,#.:9 2#)$:8 2#)$:7 < = A6 4 A4 5 6 A6 A6

/ 1 1

slide-17
SLIDE 17

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

!79!,)79)(-%64!X(9'()X1

( 4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9 4 9 8 7 ,6 ,4 1,#.:9 2#)$:8 2#)$:7 < = A6 4 A4 5 6 A6 A6

/ 1 1 / 1 1

slide-18
SLIDE 18

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

!79!,)79)(-%64!X(9'()X1

( 4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9 4 9 8 7 ,6 ,4 1,#.:9 2#)$:8 2#)$:7 < = A6 4 A4 5 6 A6 A6

Y 1 / Y 1 /

slide-19
SLIDE 19

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'("%&!9&

! *AFJB>EAMN'(1^_Y #Z((&MNFIJBC'(1^^Y ! 6#?>HAC?A>J([ 9E# *8.(,')(#-7#(520',(,-0' 9E ,0()/)5#'-.8(,-0'#-7## 9E# !25,14#Q):(-5 ! IFPP=CJ(=L(A(6#?>HAC?A>J([((((#Z((IFPP`[a 9E# ')(#-7#(520',(,-0' 9E ')(#-7#(520',(,-0'#,0Q-.Q)<M#,3)3# # ! U?>?UAO(6#?>HAC?A>JI 9E (4)5)#,'#0-#R9,0Q25,20(#A,(4#2#'*2..)5#'8CC-5( 9E /:S#-7#2..#0-09D)5-#)0(5,)'#,'#@ ! A>K(6#?>HAC?A>J(?I(A(>=>#>BGAJ?HB(O?>BAC(M=UE?>AJ?=>(=L(U?>?UAO(=>BI 9E *8.(,C.,:2(,-0#A,(4#2#C-',(,Q)#,0()/)5 9E 2<<,(,-0 9E S,Q,',-0#;&#2#:-**-0#<,Q,'-5 !" ! " ! " !

  • "

" # !

  • $"

%#"# #

  • "
slide-20
SLIDE 20

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'(!76)4$4)6%6!27&

! 6#?>HAC?A>JI(T(`UFOJ?#a(IBJI(=L(JCA>I?J?=>I(T($AC?@N(HBMJ=C 9E D)5-#)77):(#-0#*251,0/ 9E# 5)C5-<8:,0/#2#*251,0/#T#'&'()*#'(2() ! J]=(?>JBCPCBJAJ?=>I @3# C25(,2..&#-5<)5)<#(520',(,-0#')U8)0:) #Z EBNAH?=FC(F>DBCIJA>D?>G

  • 7#(520',(,-0'#-::85,0/#-0)#27()5#(4)#-(4)5

9E '8;'(20:)#T#',/02.#7.-A >3 5).2(,Q)#(520',(,-0#7,5,0/#52()' #Z IJBADK(IJAJB(EBNAH?=FC

  • 7#(520',(,-0'#-::85,0/#C)5*20)0(.&#$#:-0:855)0(.&

9E '()2<&#'(2()#;)42Q,-85# ! A(U?>?UAO(6#?>HAC?A>J(DBL?>BI(A(M=>>BMJBD(IFE>BJ 9E# (4)#R9,0Q25,20(V'#(520',(,-0'#L(4)#'8CC-5(NM# W#2..#(4),5#C5)9#20<#C-'(9C.2:)' W#(4)#25:'#,0#;)(A))0 9E C5)9')(#-7#'8CC-5(#K#C-'(9')(#-7#'8CC-5(

slide-21
SLIDE 21

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'(!76)4$4)6%6!27&

! 6#?>HAC?A>JI(T(`UFOJ?#a(IBJI(=L(JCA>I?J?=>I(T($AC?@N(HBMJ=C 9E D)5-#)77):(#-0#*251,0/ 9E# 5)C5-<8:,0/#2#*251,0/#T#'&'()*#'(2() ! J]=(?>JBCPCBJAJ?=>I @3# C25(,2..&#-5<)5)<#(520',(,-0#')U8)0:) #Z EBNAH?=FC(F>DBCIJA>D?>G

  • 7#(520',(,-0'#-::85,0/#-0)#27()5#(4)#-(4)5

9E '8;'(20:)#T#',/02.#7.-A >3 5).2(,Q)#(520',(,-0#7,5,0/#52()' #Z IJBADK(IJAJB(EBNAH?=FC

  • 7#(520',(,-0'#-::85,0/#C)5*20)0(.&#$#:-0:855)0(.&

9E '()2<&#'(2()#;)42Q,-85# ! A(U?>?UAO(6#?>HAC?A>J(DBL?>BI(A(M=>>BMJBD(IFE>BJ 9E# (4)#R9,0Q25,20(V'#(520',(,-0'#L(4)#'8CC-5(NM# W#2..#(4),5#C5)9#20<#C-'(9C.2:)' W#(4)#25:'#,0#;)(A))0 9E C5)9')(#-7#'8CC-5(#K#C-'(9')(#-7#'8CC-5(

slide-22
SLIDE 22

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'(!76)4$4)6%6!27&

! 6#?>HAC?A>JI(T(`UFOJ?#a(IBJI(=L(JCA>I?J?=>I(T($AC?@N(HBMJ=C 9E D)5-#)77):(#-0#*251,0/ 9E# 5)C5-<8:,0/#2#*251,0/#T#'&'()*#'(2() ! J]=(?>JBCPCBJAJ?=>I @3# C25(,2..&#-5<)5)<#(520',(,-0#')U8)0:) #Z EBNAH?=FC(F>DBCIJA>D?>G

  • 7#(520',(,-0'#-::85,0/#-0)#27()5#(4)#-(4)5

9E '8;'(20:)#T#',/02.#7.-A >3 5).2(,Q)#(520',(,-0#7,5,0/#52()' #Z IJBADK(IJAJB(EBNAH?=FC

  • 7#(520',(,-0'#-::85,0/#C)5*20)0(.&#$#:-0:855)0(.&

9E '()2<&#'(2()#;)42Q,-85# ! A(U?>?UAO(6#?>HAC?A>J(DBL?>BI(A(M=>>BMJBD(IFE>BJ 9E# (4)#R9,0Q25,20(V'#(520',(,-0'#L(4)#'8CC-5(NM# W#2..#(4),5#C5)9#20<#C-'(9C.2:)' W#(4)#25:'#,0#;)(A))0 9E C5)9')(#-7#'8CC-5(#K#C-'(9')(#-7#'8CC-5(

slide-23
SLIDE 23

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-24
SLIDE 24

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/ JC?H?AO(U?>Q(6#?>HAC?A>JI(`ba

! E=F>DACK(JCA>I?J?=>I(=L AF[?O?ACK(M=UP=F>DI 9E L/X2M#5X2NM#L/X;M#5X;NM# L/X:M#5X:N ! CBHBCI?EOB(CBAMJ?=>I 9E L5YM#5YX5)QNM#L5ZM#5ZX5)QN

>=>#JC?H?AO(U?>Q(6#?>HAC?A>JI(`_a

! M=HBC?>G E=F>DACK(JCA>I?J?=>I(=L ?>PFJ(c(=FJPFJ(M=UP=F>DI( 9E ,T-9R9,0Q25,20(' ! ?>>BC(MKMOBI(

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8

#Z(96!

slide-25
SLIDE 25

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

! ?c=#6#?>HAC?A>J'(B[AUPOB @># [######?35@############F##@ [######@35>##############F##@M ##### [######H35ZX5)Q#######F##@M ##### [######\35]##############F##@M ##### [######Y35^##############F##@M ##### [######_35_##############F##>M ##### [#####@>35@@###########F##>M ##### [#####@H3/XG##########F##@M ##### [#####@\35X`###########F##>M ## [#####@Y3/X;##########F##\M ##### [#####@Z35X:###########F##\M ##### [#####>?35X2###########F##\#

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-26
SLIDE 26

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

! ?c=#6#?>HAC?A>J'(B[AUPOB @># [######?35@############F##@ [######@35>##############F##@M ##### [######H35ZX5)Q#######F##@M ##### [######\35]##############F##@M ##### [######Y35^##############F##@M ##### [######_35_##############F##>M ##### [#####@>35@@###########F##>M ##### [#####@H3/XG##########F##@M ##### [#####@\35X`###########F##>M ## [#####@Y3/X;##########F##\M ##### [#####@Z35X:###########F##\M ##### [#####>?35X2###########F##\# ! IFU(BdFAJ?=> G#W#\;#9E#>`#W\2#W#\:

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-27
SLIDE 27

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

! ?c=#6#?>HAC?A>J'(B[AUPOB @># [######?35@############F##@ [######@35>##############F##@M ##### [######H35ZX5)Q#######F##@M ##### [######\35]##############F##@M ##### [######Y35^##############F##@M ##### [######_35_##############F##>M ##### [#####@>35@@###########F##>M ##### [#####@H3/XG##########F##@M ##### [#####@\35X`###########F##>M ## [#####@Y3/X;##########F##\M ##### [#####@Z35X:###########F##\M ##### [#####>?35X2###########F##\# ! IFU(BdFAJ?=> G#W#\;#9E#>`#W\2#W#\:

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-28
SLIDE 28

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

! ?c=#6#?>HAC?A>J'(B[AUPOB @># [######?35@############F##@ [######@35>##############F##@M ##### [######H35ZX5)Q#######F##@M ##### [######\35]##############F##@M ##### [######Y35^##############F##@M ##### [######_35_##############F##>M ##### [#####@>35@@###########F##>M ##### [#####@H3/XG##########F##@M ##### [#####@\35X`###########F##>M ## [#####@Y3/X;##########F##\M ##### [#####@Z35X:###########F##\M ##### [#####>?35X2###########F##\# ! IFU(BdFAJ?=> G#W#\;#9E#>`#W\2#W#\:

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-29
SLIDE 29

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

! ?c=#6#?>HAC?A>J'(B[AUPOB @># [######?35@############F##@ [######@35>##############F##@M ##### [######H35ZX5)Q#######F##@M ##### [######\35]##############F##@M ##### [######Y35^##############F##@M ##### [######_35_##############F##>M ##### [#####@>35@@###########F##>M ##### [#####@H3/XG##########F##@M ##### [#####@\35X`###########F##>M ## [#####@Y3/X;##########F##\M ##### [#####@Z35X:###########F##\M ##### [#####>?35X2###########F##\# ! IFU(BdFAJ?=> G#W#\;#9E#>`#W\2#W#\:

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-30
SLIDE 30

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

! ?c=#6#?>HAC?A>J'(B[AUPOB @># [######?35@############F##@ [######@35>##############F##@M ##### [######H35ZX5)Q#######F##@M ##### [######\35]##############F##@M ##### [######Y35^##############F##@M ##### [######_35_##############F##>M ##### [#####@>35@@###########F##>M ##### [#####@H3/XG##########F##@M ##### [#####@\35X`###########F##>M ## [#####@Y3/X;##########F##\M ##### [#####@Z35X:###########F##\M ##### [#####>?35X2###########F##\# ! IFU(BdFAJ?=> G#W#\;#9E#>`#W\2#W#\:

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-31
SLIDE 31

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

! ?c=#6#?>HAC?A>J'(B[AUPOB @># [######?35@############F##@ [######@35>##############F##@M ##### [######H35ZX5)Q#######F##@M ##### [######\35]##############F##@M ##### [######Y35^##############F##@M ##### [######_35_##############F##>M ##### [#####@>35@@###########F##>M ##### [#####@H3/XG##########F##@M ##### [#####@\35X`###########F##>M ## [#####@Y3/X;##########F##\M ##### [#####@Z35X:###########F##\M ##### [#####>?35X2###########F##\# ! IFU(BdFAJ?=> G#W#\;#9E#>`#W\2#W#\:

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-32
SLIDE 32

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

! ?c=#6#?>HAC?A>J'(B[AUPOB @># [######?35@############F##@ [######@35>##############F##@M ##### [######H35ZX5)Q#######F##@M ##### [######\35]##############F##@M ##### [######Y35^##############F##@M ##### [######_35_##############F##>M ##### [#####@>35@@###########F##>M ##### [#####@H3/XG##########F##@M ##### [#####@\35X`###########F##>M ## [#####@Y3/X;##########F##\M ##### [#####@Z35X:###########F##\M ##### [#####>?35X2###########F##\# ! IFU(BdFAJ?=> G#W#\;#9E#>`#W\2#W#\:

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-33
SLIDE 33

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'()X/

! ?c=#6#?>HAC?A>J'(B[AUPOB @># [######?35@############F##@ [######@35>##############F##@M ##### [######H35ZX5)Q#######F##@M ##### [######\35]##############F##@M ##### [######Y35^##############F##@M ##### [######_35_##############F##>M ##### [#####@>35@@###########F##>M ##### [#####@H3/XG##########F##@M ##### [#####@\35X`###########F##>M ## [#####@Y3/X;##########F##\M ##### [#####@Z35X:###########F##\M ##### [#####>?35X2###########F##\# ! IFU(BdFAJ?=> G#W#\;#9E#>`#W\2#W#\:

4 4C 4D 4D ,:* E:* ,:2 E:2 ,:! E:! ,:F E:9 ,66 ,G ,C ,5 ,6H ,D ,I ,J ,K ,4 ,6 * ! 2 * F ! 2 2 ! . * L 2 ! 2 ! M N O P 7 9 8 4B 4B 4B IB IB IB

slide-34
SLIDE 34

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

6#!7<%4!%76&'(2"&)4<%6!27&

! 6#?>HAC?A>JI(UAK(M=>JA?>(A>K(IJCFMJFCB ! 6#?>HAC?A>JI(GB>BCAOOK(=HBCOAP 9E#:-*;,02(-5,2.#)77):(#;5,0/'#)BC.-',-0#,0#(4)#08*;)5#-7#*,03#R9,0Q25,20('###`(/(e(a

slide-35
SLIDE 35

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

  • 2,3*%4!5%6!27(%7,(

8!)4%498!9%*(4)$4)&)76%6!27( 3&!7S(6#!7<%4!%76&

slide-36
SLIDE 36

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

  • 2,3*%4!5%6!27(%7,(

8!)4%498!9%*(4)$4)&)76%6!27( 3&!7S(6#!7<%4!%76&

!"#)21(*)3(#0$4$'0$'(#(*)'15(5/'#1$(1 6#)0(!1$(1#7

slide-37
SLIDE 37

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%,6#&)6&'()X1 ((

4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9

1 1 /

6#!7<%4!%76(1 6#!7<%4!%76(/

5@F####G#9E#>#+#

4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9

/ 1 Y

4 4

5>F#>#G#9E#H#I

slide-38
SLIDE 38

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%,6#&)6&'()X1

( 4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9

1 1 /

6#!7<%4!%76(1 6#!7<%4!%76(/

5@F####G#9E#>#+#

4 5 2#)$:7 2#)$:8 ,4 ,6 1,#.:9 7 8 9

/ 1 Y

4 4

5>F#>#G#9E#H#I

slide-39
SLIDE 39

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%"&64%96(,)$)7,)76(64%7&!6!27(&)6&(`%,6#&)6&a

! *BJ(!"DB>=JB(A(IBJ(=L(`AOO(c(>=>#JC?H?AOa(U?>?UAO(6#?>HAC?A>JI(#"=L(A(G?HB>($7Q ! DBPB>DB>MK(CBOAJ?=>R 6]=(JCA>I?J?=>I"$'(%(DBPB>D(=>(BAMN(=JNBC'( ?L(JNBK(AO]AKI(APPBAC(J=GBJNBC(?>(AOO(U?>?UAO(6#?>HAC?A>JI(#'(?QBQ (( !"" ! BdF?HAOB>MB(CBOAJ?=>(?>(JNB(JCA>I?J?=>(IBJ'(OBAD?>G(J=(A(PACJ?J?=>(=L(6 9E 5)7.)B,Q) 9E '&**)(5,: 9E# (520',(,Q) ! JNB(BdF?HAOB>MB(MOAIIBI(&(CBPCBIB>J(UA[?UAO(%,6#IBJI "" !" " &

  • #

'()) "

  • *

'()) "

  • "

&

  • +

'()) "

  • +

'()) "

  • "
slide-40
SLIDE 40

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%,6#&)6&'()X/

( ,4 ,6 1,#.:9 9

5@F####G#9E#>#+#

4 5 2#)$:8 8 4

5>F#>#G#9E#H#+

slide-41
SLIDE 41

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%,6#&)6&'()X/

( ,4 ,6 1,#.:9 9

1 1

6#!7<%4!%76(1 6#!7<%4!%76(/

5@F####G#9E#>#+#

4 5 2#)$:8 8

/ 1 Y

4

5>F#>#G#9E#H#+ /

,4 ,6 1,#.:9 9 4 5 2#)$:8 8 4

slide-42
SLIDE 42

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%,6#&)6&'()X/

( ,4 ,6 1,#.:9 9

1 1

6#!7<%4!%76(1 6#!7<%4!%76(/

5@F####G#9E#>#+#

4 5 2#)$:8 8

/ 1 Y

4

5>F#>#G#9E#H#+ /

,4 ,6 1,#.:9 9 4 5 2#)$:8 8 4

slide-43
SLIDE 43

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%,6#&)6&'(%$$*!9%6!27&

! UA[?UAO(%,6#IBJI 9E 0-(#0):)''25,.&#:-00):()< ! DBM=UP=I?J?=>(?>J=(M=>>BMJBD(%,6#IBJI 9E C-'',;.&#2::-5<,0/#(-#C5,*25&#:-*C-80<'M#-0.&M ,3)3#0)/.):(,0/#:-00):(,-0'#;&#28B,.,25&#:-*C-80<' 9E 0-09*2B,*2.#GSR9')(' ! M=ACIB(>BJ]=C@(IJCFMJFCB'(DBL?>?J?=>( 9E *2:5-#(520',(,-0'# 9# 2;'(52:(#75-*#:-00):()<#GSR9')(' 9E C.2:)' 9# ,0()572:)#;)(A))0#:-00):()<#GSR9')(' ! M=ACIB(>BJ]=C@(IJCFMJFCB'(]NAJ(L=CV 9E ')(#-7#R9,0Q25,20('#/)('#'(58:(85)< 9E ;)(()5#80<)5'(20<,0/#-7#(4)#0)(#;)42Q,-85

slide-44
SLIDE 44

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

"!2($)64!(7)6&' &2-)()X%-$*)&

slide-45
SLIDE 45

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)X1(#(SOKM=OKI?I(A>D($B>J=IB($N=IPNAJB($AJN]AK

(

#$%& ' % ($%& #%& ) *+& ,-& + .'& /)& ,-& 1% 2-34 4 &5 ,)& /)& 1!

  • 6&
  • 3&

/7& 11 18 39-& 1: 1'

  • 6&
  • 3&

; ,<$= 1>:?7&,

  • 6&
  • 3&

1)

  • 6&
  • 3&

1; 2-34 2-39 8! :&, 1+ 8&, &.& 10 &@A BC= 8D2-3&4 8D2-3&9 'D,*9 8 : 1 8D,**, 2-39

f4BDDK(1^^Yg

slide-46
SLIDE 46

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)X1(#(SOKM=OKI?I(A>D($B>J=IB($N=IPNAJB($AJN]AK

(

NADP+ NADPH GSSG GSH Ru5P Xu5P R5P S7P GAP GAP E4P F6P F6P Gluc G6P FBP DHAP 1,3−BPG 3PG 2PG PEP Pyr Lac NAD+ NAD+ NADH NADH Pi Pi ATP ATP ATP ATP ATP ADP ADP ADP ADP ADP 15 16 17 18 19 20 13 14 12 11 10 9 2 1 3 4 5 6 7 8 2 2 2 2

f8)!7)4(1^^hg

slide-47
SLIDE 47

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)X1(#(SOKM=OKI?I(A>D($B>J=IB($N=IPNAJB($AJN]AK

GAP GAP F6P F6P G6P DHAP G6P 13 14 10 10 red blue1 blue3 blue2 red blue1 blue2_3

slide-48
SLIDE 48

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)X1(#(SOKM=OKI?I(A>D($B>J=IB($N=IPNAJB($AJN]AK

GAP GAP F6P G6P G6P F6P B 10 B 10 A1 C A2 A1 C A2

slide-49
SLIDE 49

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)X/R(%$2$62&!&(!7(-%--%*!%7(9)**&

fS27(/00Yg

slide-50
SLIDE 50

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)X/R(%$2$62&!&(!7(-%--%*!%7(9)**&

Fas−Ligand FADD Procaspase−8 Caspase−8 Bid BidC−Terminal Bax_Bad_Bim Apoptotic_Stimuli Bcl−2_Bcl−xL CytochromeC dATP/ATP Apaf−1 (m20) (m22) Procaspase−9 Caspase−9 Procaspase−3 Caspase−3 DFF CleavedDFF45 DFF40−Oligomer DNA DNA−Fragment Mitochondrion s1 s7 s9 s8 s5 s10 s11 s2 s12 s13 s3 s4 s6

f8)!7)4i(;298i(:!**(/00eg fS27(/00Yg

slide-51
SLIDE 51

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)X/R(%$2$62&!&(!7(-%--%*!%7(9)**&

Caspase-8 Procaspase-3 Caspase-3 Mitochondrion s2

slide-52
SLIDE 52

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)X/R(%$2$62&!&(!7(-%--%*!%7(9)**&

$1*$'AC <,#2*$1*$'A5 $1*$'A5 Q"&#20#).,"#) Q"&#20#).,"#) 7*$1*$'A5 <,#2*$1*$'A5 7*$1*$'AC Q"&#2 7*$1*$'A5 <,#2*$1*$'A5 7*$1*$'AC 8 4 74 EC 74 EC 8 4 74 EC 8 4 9 L P 76 O 9 L P 76 O 9 L P 76 O

slide-53
SLIDE 53

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)XY(#(8.$2X!%

f.3()6(%*Q(/00_g

!"#$%&'( !"#)*+,-$%&.( !"#)*+,-)!+/$%&0( !"#)1!2$%&3'( !"#$%&'() *+,-./0123-4 5+4 6.5780-$95., *+,-$%&4( !"#)*+,-)1!2$%&3.( !+/$%&5( !"#6!)*+,-)!+/$%&77( !"#6!)*+,-$%&35( !"#)8!%&34( !"#6!)9!:%&3;( 9!:$%&30( <+,* "=>?@<?ABC>?D' "=>?@<?ABC>?D7 "=>?@<?ABC>?D3

67 67

!"#$%$!"& !#'$%$!&( !##$%$!#" !")%$!"* !)$%$!* !&$%$!+ !" !# !",$%$!"' !"+ !"" !"- !#( !"( !' !, !- !-

:( 8+4-9-+4-+, 95,;<5=/' :( 4-9-+4-+, !5,;<5= / ( :( 4-9-+4-+, !5,;<5= / ' #-7.545,81+ 95,;<5=

slide-54
SLIDE 54

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)XY(#(8.$2X!%

S7 H1F:ARNT:HRE S5 H1F:ARNT S3 H1F S13 H1F:PHD S14 H1FOH S18 H1FOH:VAL S17 VHL S12 PHD S4 ARNT S15 H1F:ARNT:PHD S16 H1FOH:ARNT S6 HRE S22 H1FOH:ARNT:HRE O2 Oxygen O2 Oxygen k1 k2 k12 k13 k14 k19 k18 k20 k4 k3 k15 k16 k17 k21 k22 k6 k5 k29 k30

f8)!7)4i(&4!4%-(/010g

slide-55
SLIDE 55

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)XY(#(8.$2X!%

S5 H1F:ARNT S3 H1F S13 H1F:PHD S14 H1FOH S18 H1FOH:VAL S17 VHL S12 PHD S4 ARNT S15 H1F:ARNT:PHD S16 H1FOH:ARNT O2 Oxygen O2 Oxygen k1 k2 k12 k14 k18 k20 k3 k15 k17 k22

slide-56
SLIDE 56

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)XY(#(8.$2X!%

S3 H1F S14 H1FOH S12 PHD k1 A k2 B k18, k20 E k12, k14 C k3, k15, k17, k22 D

slide-57
SLIDE 57

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)XY(#(8.$2X!%

R64 <MP R6I M6LSM R5 M6L R64 <MP R6I M6LSM R5 M6L R64 <MP R6I M6LSM R5 M6L T4 8 T6 9 T4 8 T6 9 T4 8 T6 9 T6CU3T4H O T64U3T6I 7 T5U3T6GU3T6JU3T44 P T6CU3T4H O T64U3T6I 7 T5U3T6GU3T6JU3T44 P T6CU3T4H O T64U3T6I 7 T5U3T6GU3T6JU3T44 P

slide-58
SLIDE 58

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)Xe(#(9ACE=>(-BJAE=O?IU(?>($=JAJ=(6FEBC

f;298i(j37;)4i(8)!7)4(/00bg

GSR9')('#A,(4-8(#(5,Q,2.#R9,0Q25,20('

slide-59
SLIDE 59

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

)Xe(#(9ACE=>(-BJAE=O?IU(?>($=JAJ=(6FEBC

f;298i(j37;)4i(8)!7)4(/00bg

Suc eSuc Glc Frc UDPglc G6P F6P G1P UDP UDP UTP S6P PP PP starch AMP ATP ATP ATP ATP ATP ATP ADP 29 ADP 29 ADP 29 ADP 29 ADP 29 ADP 29 Pi 28 Pi 28 Pi 28 Pi 28 SucTrans Inv HK FK SPP StaSy(b) Glyc(b) ATPcons(b) PPase rstarch geSuc SuSy SPS PGI PGM NDPkin UGPase AdK 29 29 28 2 2 2

GSR9')('#A,(4-8(#(5,Q,2.#R9,0Q25,20('

slide-60
SLIDE 60

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

&3--%4.

slide-61
SLIDE 61

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%,6#&)6&'(6BMN>?MAO?J?BI

! U?>?UAO(6#?>HAC?A>JI UA[?UAO(%,6#IBJI 9E -Q)5.2CC,0/#'8;0)(' 9E <,'J80:(,Q)#'8;0)(' 9E :-00):()< 9E 0-(#0):)''25,.&#:-00):()< ! HAC?AJ?=>I 9E A,(4#T#A,(4-8(#(5,Q,2.#R9,0Q25,20(' 9E A4-.)#T#C25(,2.#')(#-7#R9,0Q25,20(' ! MOAII?L?MAJ?=>(=L(AOO(JCA>I?J?=>I(EAIBD(=>(JNB(6#?>HAC?A>JIk(IFPP=CJ ! ?>JBCPCBJAJ?=> 9E '(58:(852.#<):-*C-',(,-0#,0(-#52(4)5#'*2..#'8;0)('# 9E '*2..)'(#;,-.-/,:2..&#*)20,0/78.#780:(,-02.#80,(' 9E ;8,.<,0/#;.-:1' M=>>BMJBD(%,6#IBJI 9E#<,'J80:(,Q)#20<#:-00):()<#'8;0)(' 0-(#0):)''25,.&#*2B,*2.#GSR9')('

slide-62
SLIDE 62

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%,6#&)6&'(!>JBCPCBJAJ?=>I

! lPC=U=JB(N?BCACMN?MAO(JN?>@?>G(m(F>E?AIBD(U=DFOAC?WAJ?=>n ! IJCFMJFCBD(CBPCBIB>JAJ?=>(=L(?>HAC?A>JI 9E *2&#:-0(5,;8()#(-#2#;)(()5#80<)5'(20<2;,.,(&# ! M=ACIB(>BJ]=C@(IJCFMJFCB(?DB>J?L?BI(IB>I?J?HB(>BJ(PACJI( 9E (4)#10-:19-77#-7#,0()572:)#C.2:)'#277):('#')Q)52.#GSR9')(' ! (BLL?M?B>J(DBI?G>(=L(]BJOAE(B[PBC?UB>JI 9E *,0,*2.#')('#-7#-;')5Q2(,-0#C-,0('#C5-Q,<,0/#:-Q)52/)#-7#(4)#A4-.)#0)(A-51# L-0)#7-5#)2:4#GSR9')(#N ! IFPP=CJ(=L(DBD?MAJBD(OAK=FJ(AOG=C?JNUI a:20#,0:.8<)#0-09-;Q,-8'#/5-8C'#-7#5)2:(,-0'#20<#<,77)5#75-* /5-8C,0/'#-7#5)2:(,-0'#;2')<#-0#2#Q,'82.#,0'C):(,-0#-7#(4)#0)(A-51#(-C-.-/&b ##L!2C,0M#c))<M#!2.''-0#>??\N

slide-63
SLIDE 63

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

%,6#&)6&'(&3--%4.

! $42& 9E 2./-5,(4*,:2..&#<)7,0)< 9E '(2(,:#202.&','#():40,U8)#L'(2()#'C2:)#0-(#:-0'(58:()<NM A-51'#2.'-#7-5#80;-80<)<#*-<).' ! 927& 9E *2&#;)#:-*C8(2(,-02.#)BC)0',Q)# 9E##(-#2Q-,<#:-*C8(2(,-0#-7#2..#LR9N#,0Q25,20('F#

##()&$)9!%**.(8)*$+3*(+24(%7%*.5!7S("!2($)64!(7)6&(##

M### !" ! " ! " !

  • "

" # ! " * ! # * ,

  • "
slide-64
SLIDE 64

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

4)+)4)79)&

! CBOAJBD(]=C@ 9E# C25(,2..&#:-55).2()<#5)2:(,-0#')('#L!2C,0M#c))<M#!2.''-0#>??\N 9E O.8B#:-8C.,0/#202.&','#L+85/25<#>??\N 9E =IR9')('#L%2:1*200M#d),0)5M#`-:4#>??]N 9E# LGNSR9')('#Le,0<)5#>??]N 3#3#3 9E C5-;2;.&#'-*)#*-5)# ! Q3M'")',V f0<)5'(20<,0/#")(A-51#+)42Q,-85#;&#%(58:(85)<#c)C5)')0(2(,-0'#-7#R520',(,-0# g0Q25,20('#9#G#!)(5,#")(#!)5'C):(,Q)#-0#%&'()*'#20<#%&0(4)(,:#+,-.-/&h3 ")33937#).#)U3P3M*,'-U3WX3F#TU393R*-#(**U3O3Y")Z,''3['.$>\V39-E#,"&0("238"#1,#2A '$$'$]370*1&',36DU3R1,")E',U3W+-%34HHD> ! Q3M'")',U3F3R,",*(V R&,+2&+,*-39)*-%$"$3&#3P'&',(")'3&0'37#,'3#Z3M%1#B"*3^'$1#)$'3X'&_#,T] <`#R3SXO3G[6\V3'CKHHU3.#"V6H>65J6a;#+,)*->1#)'>HHHCKHHU3W*)+*,%34H6H>

slide-65
SLIDE 65

!"#$#%&'()*'#+,-.-/& *-0,1234),0)56,07-5*2(,13(89:-((;8'3<) #####=2&#>?@?

68%7;&(o

866$Rcc:::#,&&5Q!7+24-%6!;Q63#9266"3&Q,)