1 Introduction of XtremIA – 5th of December 2017 10 Janvier 2016
Pierrick DREVILLON, Msc, MBA ESCP (Paris) Co-foundeur of Xtremia INSEMINATION 2.0 … FOR ALL FARMERS , FOR ALL SPECIES
A T TECHN HNICAL CAL REVOLU LUTI TION, ON, INSEMIN MINATION ATION 2.0. THE DEEP ARTIFICIAL INSEMINATION: AN ALREADY MASTERED TECHNIQUE!
AI : an omnipresent technique in the world … 110 million ≈ 100 000 Almost 100% of AI in the 2.8% of born 80% of born for some bird mares world children in piglets species like inseminated France 1 / 2 cow in / year turkey France AI : a growing ng-up p techniq nique ue for the last t 70 70 years ! 4
5 An increasingly reduced fertility in World Dairy farms … • Lack of expression (low • Negative genetic Selection at P4 rates) correlations between • Lack of observation by the expense milk production and of fertility the breeder fertility On average: ↑ of the -50% fertility on Montbéliarde Insufficient number of cows in AI1 heat animals with -45% in Normande cows detection genital risks - ≈ 35% in Holstein cows (Le Mezec et al, 2010) • Selection of overturned • Sexed semen (2M basin animal Use of new spz/dose) ≠ biotechnologies uro/pneumovagina conventional semen (10M spz/dose)
6 Development of Deep AI in species Genital tracts AI in fresh AI in fresh and frozen AI in fresh and frozen Dose price: 3-7 € Dose price: 200-3 000 € Dose price: 25-50 € Goal: prolificacy Goal: low [dose] Goal: Sexed semen
7 Development of Deep AI in species Existing DAI devices 75 cm Equine deep AI catheter (Minitüb) Ghent Device (University of Gand), Aspi Gun (IMV), Extra-Flex (Minitüb) ? DeepGoldenPig (IMV), Gédis (Gènes Diffusion), UnicSoft (Cobiporc)
A TECHNICAL TECHNICAL RE REVOLUTIO VOLUTION, N, IN INSEMINATIO SEMINATION N 2. 2.0. 0.
9 XtremiA : a real changing equipment … A safe handling… • Direct use of 0.25ml straws in the device : no risk of destruction of the sperm. • Drop off by a retraction of the sheath : securing the gesture for the animal. Health safeguards… The final touch... • Individual packages with sanitary • Drop the semen up to 25 cm into sheats. the uterine horn. • Consumable and non reusable • Without any constraint for the sheats. operator: the material adapts itself to the animal anatomy. • Perspective of diversification in ET.
10 Xtrem-ET : the revolution in embryo transfer Esayslide, a specific cap with a lateral exit … Time for Embryo Transfer 2.0 Reduced cross-section for a better passage through the closed cervixes of recipients of Rounded extremity with a heifers dilatory effect to facilitate the catheter’s progression into the cervixes
11 Xtrem-ET : the revolution in embryo transfer The first The end of Improved Use cows as transfer device spinal results recipients ! for all users ! anaesthetic
A T A TEC ECHN HNICAL CAL REV EVOLUTI LUTION, ON, INSEMIN MINATION ATION 2.0. NON-EXHAUSTIVE APPLICATION EXAMPLES IN BREEDING
1. SEXED SEMEN
Number of spermatozoids/AI Spectrum of action of the dose male spermatozoids Spectrum of action of the Spectrum of action of the In millions of female spermatozoids female sexed semen spermatozoids/AI dose 12 10 8 6 4 2 5 h 7h 9h 11 13 15 17 19 21 23 1 3 5 7 9 11 13 14 Time Minimum 12h Fertilization window IA Heat detection Sexed semen
Millions Billion Thousands
Millions Spermatozoids in strength and number
17 Results of the tests conducted during summer 2014 Experimental results: • Calving rates, depending on the type of semen 70.00% + 15.2% difference(+ 6.43 pts) ! b 57.7% 60.00% a a 51.3% 48.7% b 50.00% 42.3% 40.00% E N = 314 N = 662 T 30.00% 20.00% 10.00% 0.00% Sexée Gestation Sexée Pas de gestation
2. EMBRYOS
The epidural: a working comfort, a guarantee for the breeder , but… 19
No more epidural Simplified pose
3. HIGHLY PRODUCING COWS
Ketones ↑ the prevalence of mucus ↑ the appearance of free radicals ↑ the inflammation
4. THE CASE OF THERMAL STRESS
THERMAL STRESS
THERMAL STRESS
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