1 Tyrosine Tyrosine TH [ 18 F] FDOPA DOPA DDC Amphetamine - - PDF document

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Tyrosine

Tyrosine

Amphetamine Reserpin Tetrabenazine

DA DOPA TH DDC

DOPAC HVA DA [18F] FDOPA [18F] FPCIT [123I] βCIT, FPCIT [11C] cocaine, d-threo-methylphenidate

DAT

D1 D2

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Normal Mild Moderate Severe

[18F] FPCIT/PET

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18F-FPCIT Binding Reductions in PD

H&Y Stage I

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Figure 8 Eidelberg D

Normal Fetal mesencephalic cell implant FDOPA / PET Postop. Preop. Postop. Preop. Sham surgery

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5 4 3 2 1

Fetal Dopamine Cell Transplant FDOPA/PET: SPM Analysis (p<0.001)

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18F-FDG 18F-FPCIT

Parkinson’s Disease H&Y I

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Pons Cerebellum Th PU / GP PMC

PD-related Metabolic Network: Voxel Analysis

(z = -30mm) (z = 54mm) (y = -10mm)

PreSMA Posterior Parietal

PC1 (20.7% VAF) from analysis of 20 PD and 20 Controls

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Network Activity Discriminates PD and Controls

• 30
• 20
• 10

10 20 30 40

Subject Score (PDRP)

PD Normal

p < 0.0001

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• 30
• 20
• 10

10 20 30

OFF ON

PDRP SCORE

Levodopa Infusion

*

* p = 0.01

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PARKINSON’S DISEASE

PUTAMEN GPL GPM STN SNR BC PPN VA-VL

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preoperative 1 yr postop 2 yr postop

Implantation: Two year Follow-up

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MRI-PET Fusion Image Pallidotomy

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18 F-FDG/PET

63 yrs man rt. pallidotomy

Pre Post

14.0 mg/100g/min

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Task Subtractions

52 mm 40 mm

• 36 mm

8 mm

p<0.001

SMA Sensorimotor Thalamus Dentate Vermis preSMA PMC Superior Parietal Lateral cerebellum

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Effect of GPi stimulation on motor task

0 mm

• 40 mm

52 mm 72 mm Threshold p=0.01 (within motor activation mask)

Activation ON > Activation OFF

SMA Motor Putamen Med Cerebellum

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SNr VA / VL DN GPi PPN DN

Effect on Brain Glucose Metabolism

(p < 0.001)

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