1 Tyrosine Tyrosine TH [ 18 F] FDOPA DOPA DDC Amphetamine - PDF document

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Tyrosine Tyrosine TH [ 18 F] FDOPA DOPA DDC Amphetamine Reserpin DA Tetrabenazine DAT [ 18 F] FPCIT DOPAC DA [ 123 I] β CIT, FPCIT HVA [ 11 C] cocaine, d-threo-methylphenidate D2 D1 NSUH NSUH [ 18 F] FPCIT/PET 18F-FPCIT Binding Reductions in PD H&Y Stage I Mild Moderate Normal Severe NSUH NSUH Sham surgery Fetal Dopamine Cell Transplant FDOPA / PET Preop. Postop. Fetal mesencephalic cell implant 5 4 Normal 3 2 1 Figure 8 0 Eidelberg D FDOPA/PET: SPM Analysis (p<0.001) Preop. Postop. NSUH NSUH 2

Parkinson’s Disease PD-related Metabolic Network: Voxel Analysis H&Y I 18 F-FPCIT 18 F-FDG PreSMA PMC Pons 2.5 3.0 PU / GP 2.0 Posterior 2.5 Cerebellum Th 1.5 2.0 Parietal 1.5 1.0 (z = -30mm) (y = -10mm) (z = 54mm) PC1 (20.7% VAF) from analysis of 20 PD and 20 Controls NSUH NSUH Levodopa Infusion Network Activity Discriminates PD and Controls 30 p < 0.0001 * 40 20 Subject Score (PDRP) 30 PDRP SCORE 10 20 0 10 -10 0 -10 -20 -20 * p = 0.01 -30 OFF ON -30 PD Normal NSUH NSUH Implantation: Two year Follow-up PUTAMEN VA-VL GP L GP M STN SNR PARKINSON’S DISEASE preoperative 1 yr postop 2 yr postop BC PPN NSUH NSUH 3

NSUH NSUH NSUH NSUH MRI-PET Fusion Image 18 F-FDG/PET Pallidotomy mg/100g/min 63 yrs man rt. pallidotomy 14.0 Pre Post 0 NSUH NSUH 4

Task Subtractions Effect of GPi stimulation on motor task SMA preSMA 52 mm Activation ON > Activation OFF PMC Sensorimotor Superior Parietal Putamen Med Cerebellum SMA Motor 40 mm Thalamus 8 mm 52 mm 0 mm 72 mm -40 mm -36 mm Lateral Dentate Threshold p=0.01 (within motor activation mask) cerebellum p<0.001 Vermis NSUH NSUH Effect on Brain Glucose Metabolism VA / VL SNr GPi DN (p < 0.001) PPN DN NSUH NSUH NSUH NSUH 5

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