1 Satellit project on project MDMA & Mem ory Database 1 : MDMA - - PDF document

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1 Satellit project on project MDMA & Mem ory Database 1 : MDMA - - PDF document

Reference corpus of Dutch drug users I : IAFPA research grant MDMA / Ecstasy Viktria Papp, Rice University/ NZI LBB Maartje Schreuder, Eef Theunissen, Jan Ramaekers, Maastricht University I AFPA 2011 Bundeskrim inalam t Vienna, Austria


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Reference corpus of Dutch drug users I : MDMA / Ecstasy

Viktória Papp, Rice University/ NZI LBB Maartje Schreuder, Eef Theunissen, Jan Ramaekers, Maastricht University

I AFPA 2011 Bundeskrim inalam t Vienna, Austria July 27, 2011 Faculty of Psychology and Neuroscience

IAFPA research grant

Faculty of Psychology and Neuroscience

Overview

  • Drugs-intoxicated speech databases
  • Research context
  • Database 1: Methyleen Dioxy Meth Amphetamine

(Ecstasy)

Faculty of Psychology and Neuroscience

Drugs- intoxicated speech

  • Wire-tapped phone calls

– Drugs-related crimes – Under the influence of drugs

  • Effects of alcohol quite well-described

– Effects of heroin: Papp (2008) – Effects of other drugs: unknown

  • Relevant for forensic speaker

identification/ verification

Faculty of Psychology and Neuroscience

Psychopharm acological drugs research Research team:

  • E.L. Theunissen, PhD (Project Manager,

Investigator)

  • J.G. Ramaekers, PhD (Principle investigator)
  • K.P.C. Kuypers, PhD (Co-investigator)
  • C.J. van Leeuwen, MD (Medical Supervisor)
  • Anique van Dorp, MD (Medical Supervisor)

Maastricht University, Department of Psychopharmacology & Neuropsychology

Faculty of Psychology and Neuroscience

Drugs

  • CNS depressants

– Alcohol – Heroin

  • CNS Stimulants

– Cocaine

  • Hallocinogens and Psychedelics

– Cannabis – MDMA (Ecstasy) (CNS = Central Nervous System)

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Faculty of Psychology and Neuroscience

Satellit project on project “MDMA & Mem ory perform ance”

  • Acute administration of MDMA causes memory

deficits in humans

  • Aim to investigate whether memantine (Alzheimer’s

disease medication) can reverse the memory impairment caused by acute MDMA administration in humans

  • Ethical approval granted (NL35155.068.11 / MEC 11-3-007)

Start: August (first week)

Faculty of Psychology and Neuroscience

1st treatment placebo

  • r

Memantine 2nd treatment placebo or MDMA placebo

  • r

MDMA Treatment 1 2 3 4

Database 1 : MDMA ( Ecstasy)

The four-way crossover study design (double blind, (pseudo-)random).

Faculty of Psychology and Neuroscience

Methodology

  • 16 participants (within subjects design)
  • All recreational users of MDMA, not addicted
  • Medical tests
  • Drugs/alcohol tests on each test day

As recommended by Morrison et al. (in press):

  • 2 x 4 non-contemporaneous recordings of each speaker
  • Within each session: different speaking styles
  • each session (at the same time):

– recorded in studio quality – recorded through a mobile phone line

Faculty of Psychology and Neuroscience

Speaking styles, stimulus m aterials

  • Word lists (35 words), read 3x,

within sentence ‘I k zeg nu het woord …tegen jou’ [ I now say the word …to you]

– Controlled for (written) frequency (Celex) – All Dutch consonants

  • + some non-Dutch consonants, in loan words
  • + some clusters
  • Combined with all Dutch vowels, on basis of

– Place – Manner – Voicing/ sonority

Faculty of Psychology and Neuroscience

Speaking styles, stimulus m aterials

  • Free (guided) conversation (through phone)
  • Picture descriptions

– With target words containing / a/ , / i/ , / u/

  • Price list com pletion of illegible text

– Numbers, strange words – Interaction – Meta speech

  • Pseudo-police-style interview on drugs use

– Also questions answered with ‘Ik maak gebruik van mijn zwijgrecht’ [ No comment]

  • Each session different lists, pictures, price lists (to overcome

repetition effect)

Faculty of Psychology and Neuroscience

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Faculty of Psychology and Neuroscience Faculty of Psychology and Neuroscience Faculty of Psychology and Neuroscience

Recordings

  • Conversation:
  • Pictures:
  • Price list:
  • Police-like interview:
(will be bett er quality)

Faculty of Psychology and Neuroscience

Recording equipment

  • Direct recordings:

– Sound-attenuated cabin – M-Audio MicroTrack 24/ 96 Memory Card recorder – Knowles electronics in-ear microphone (mini) FC-23652-P16, mounted on simple headset, Omni-directional – Windows PCM WAV, 44100 Hz, 16-bit, Mono

  • Via phone line:

– Blackberry mobile phone – B-line Yellowtec telephone hybrid – Recorded with Adobe Audition 3.0 on PC (Dell Optiplex 760 with Soundmax high definition integrated audio device sound card) – Windows PCM WAV, 44100 Hz, 16-bit, Stereo (speakers in separate channels)

Faculty of Psychology and Neuroscience

Drugs

  • CNS depressants

– Alcohol – Heroin

  • CNS Stimulants

– Cocaine

  • Hallocinogens and Psychedelics

– Cannabis – MDMA (Ecstasy) (CNS = Central Nervous System)

Faculty of Psychology and Neuroscience

Effects of MDMA

  • Intensifies bodily senses (taste, smell, touch, vision, hearing)
  • Experience mental imagery and auditory and visual distortions
  • Increased confidence, intimacy, energy, endurance, alertness

and wakefulness

  • CNS: initiating motor activity

– Starting and stopping motor events – Coordination of co-occuring events

  • respiration, initialization, phonation and articulation during speech
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Faculty of Psychology and Neuroscience

Research objectives – speech effects

Hypotheses:

  • Tim ing of articulators: delayed or uncertain
  • Reaching vowel targets and consonant loci uncertain
  • I m paired synchronizing of
– Respirat io n – Init ializat ion – Phonat io n – Art iculators
  • General m uscle stiffness, cheek stiffness
  • I ncreased energy:
– Possibly : not undershoot, but overshoot of art iculatory targets ( hyper-art iculate) – Wider f0 range – Larger pitch variat ion – Faster art iculat io n – Higher speech rate – Higher heart rate and breat h rate: decreased num ber of sy llables per breat h group – Extrem ely t alkat iv e

Faculty of Psychology and Neuroscience

MDMA – acoustic measurements

  • Vowel formant values
  • Center of gravity (/ s/ and / S/ )
  • Formant structure of nasals and laterals
  • F0 range, unit-by-unit pitch variation
  • Articulation rate
  • Speech rate
  • Number of syllables per breath group

Faculty of Psychology and Neuroscience

Perceptual differences

  • Speakers under influence of MDMA perceived

differently than without MDMA?

– If so, general perceived differences? – What differences?

  • Speakers under influence of MDMA still recognized

when speaking without MDMA?

– (And vice versa?)

Faculty of Psychology and Neuroscience

I AFPA

Corpus available to IAFPA members

Faculty of Psychology and Neuroscience

Questions