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Whats VAP got to do with it? The evolution of blood parasitism in - PowerPoint PPT Presentation

Jan 19, 2023 •199 likes •365 views

Whats VAP got to do with it? The evolution of blood parasitism in flatworms Breanna N. Sipley, Stephen A. Bullard, Jamie R. Oaks, & Kenneth M. Halanych 10 parasitic lineages contain 40% of all animal diversity Parasitism evolved at

  1. What’s VAP got to do with it? The evolution of blood parasitism in flatworms Breanna N. Sipley, Stephen A. Bullard, Jamie R. Oaks, & Kenneth M. Halanych

  2. 10 parasitic lineages contain 40% of all animal diversity Parasitism evolved at least 223 times in Animalia Weinstein & Kuris Biol Letters (2016) Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  3. Collins, J Current Biology (2017) System: Flatworms Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  4. Antagonistic coevolution btwn parasite allergens & host antibodies Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  5. What’s VAP got to do with it? Galen et al. (2012) Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  6. What’s VAP got to do with it? ● 2 main groups of VAPs Group 1: Secretory ○ ○ Group 2: Intracellular ● Secretory VAPs from parasitic flatworms may be under (+) selection Chalmers et al (2008) & Chalmers & Hoffman (2012) Galen et al. (2012) Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  7. What’s VAP got to do with it? ● 2 main groups of VAPs Group 1: Secretory ○ ○ Group 2: Intracellular ● Secretory VAPs from parasitic flatworms may be under (+) selection Chalmers et al (2008) & Chalmers & Hoffman (2012) Included only parasites with medical/ economic relevance Galen et al. (2012) Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  8. Data: 47 transcriptomes Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  9. H1: VAPs expressed in all flatworms H2: Two well-supported major VAP clades H3: Signal peptides predicted in Group 1 VAPs H4: Taxa-specific expansions in secretory VAPs Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  10. Bioinformatics pipeline Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  11. Results H1: VAPs expressed in all flatworms 474 new VAPs Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  12. Results H1: VAPs expressed in all flatworms H2: Two well-supported major VAP clades 99% bootstrap support Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  13. Results H1: VAPs expressed in all flatworms H2: Two well-supported major VAP clades H3: Signal peptides predicted in Group 1 VAPs Yes & only 1 SignalP predicted in Group 2 Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  14. Results H1: VAPs expressed in all flatworms H2: Two well-supported major VAP clades H3: Signal peptides predicted in Group 1 VAPs H4: Taxa-specific expansions in secretory VAPs Deeper exploration & tests for (+) selection to come... Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

  15. Acknowledgements Molette Lab Dr. Kenneth M. Halanych Dr. Li Yuanning Viktoria Bogantes Kyle David Damien Waits Dr. Scott Santos Phyletica Lab Mike Tassia Caitlin Redak Dr. Jamie R. Oaks (talk + workshop) Dr. Brian Folt (poster) Funding Randy Klabacka (poster) AU CMB Peak of Excellence Aundrea Westfall (talk) Research Fellowships Dr. Jesse Grismer NSF DEB-1051106 Kerry Cobb NSF GRFP Breanna.Sipley@gmail.com Phyletica Lab | Molette Lab | Auburn University

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