Welcome to the presentation of Lars Kattner Endotherm Life Science - - PowerPoint PPT Presentation
Welcome to the presentation of Lars Kattner Endotherm Life Science Molecules Science Park 2 66123 Saarbrcken Germany 1 Location Our facilities are favorably located on the campus of the Universitt des Saarlandes, Saarbrcken
Lars Kattner Endotherm Life Science Molecules Science Park 2 66123 Saarbrücken Germany
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Our facilities are favorably located on the campus
Consequently we have, besides our own facilities and personnel, access to additional
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>3000 „Inhouse-made“ research chemicals for the Life Sciences
ingredients up to 100g, intermediates, impurities
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Fluorescent probes
CCF4-AM DIFMUP 25-Hydroxyvitamin D2
OH HO OH OH HO
Stable isotopes
Calcitriol
Vitamin D metabolites
Ethosuximid-13C, d3 Zonisamid-15N d4 HMG-CoA
Coenzyme A ester
Contract research, exclusive synthesis of research chemicals for
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> Additional capacity
> High scope of resources concerning equipment and staff > State-of-the-art facilities > High safety standard > Moderate costs > Highly skilled scientific staff > Access to expertise which may not be available in-house > Professional project management > Commitment to quality > High confidentiality (protection of your IP) > Focused on timelines > Realistic match of expectations > Quick response to inquiries and immediate feedbacks > Speedy and pragmatic contract negotiations > Constant availability to talk about changes/problems/hurdles > Professional communication and reporting > High flexibility, ability to respond quickly to changing conditions > Proven track record
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20 projects 6 libraries (10-30 compounds each) 14 building blocks and reference compounds 11 projects 5 libraries (>100 compounds, >300 steps) 6 building blocks (6-8 steps each) 35 projects (API´s, 50-100g each) > 300 steps 13 projects (libraries,building blocks and reference compounds > 200 steps, 4 FTE´s over 2 years 8 projects (steroids, benzodiazepines, steroid mimetics)
New Inhibitors of MurA, an Antibacterial Target Enzyme
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O O H O O NH UDP OH O C H3 COOH H
MurA MurB
PEP NADPH+H+NADP+
UDP-N-Acetylglucosamine (UNAG) Enolpyruvyl-UNAG (EP-UNAG) UDP-N-Acetyl- Muramin acid (UNAM) Cytoplasma
C55- Carri er
Cross-linking, murein-structure MurC- F
UDP-N-Acetyl- muraminacid- pentapeptide UNAG + C55
Cell wall
O O H O O H NH UDP OH O O3PO COO O O H O O NH UDP OH O COOH O O H O O NH UDP OH O C H3 H O
L-Ala D-Glu L-Lys D-Ala D-Ala
MIC [µg/ml] Code MS SA MR SA E. coli ESBL
iella Ps. aerug . PI120 4 4 4 16 2 PI129 16 16 16 >32 8 PI131 2 2 2 16 4
Scholz T, Heyl CL, Bernardi D, Zimmermann S, Kattner L,Klein CD: Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity. Bioorg Med Chem. 2013;21:795-804.
Development of pharmacological compounds to prevent RyR2 mediated intracellular Ca2+ leak and to stabilize SERCA mediated Ca2+ uptake to inhibit arrhythmia trigger mechanisms
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Kattner L, Volmer DA. Chapter: Synthesis of low abundant vitamin D metabolites and assaying their distribution in human serum by liquid chromatography-tandem mass spectrometry (LC- MS/MS) as a new tool for diagnosis and risk prediction of vitamin D related diseases. In: Gowder S, editor. A critical evaluation of vitamin D - basic
103-127. ISBN 978-953-51-3084-0.
Lars Kattner, Ph.D., CEO Endotherm GmbH Science Park II 66123 Saarbrücken Germany Phone: ++49-(0)681-3946-7570 Fax : ++49-(0)681-3946-7571 E-Mail: info@endotherm.de www.endotherm-lsm.com
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