validation for helium ion-beam therapy MCMA 2017, Napoli Stewart - - PowerPoint PPT Presentation

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validation for helium ion-beam therapy MCMA 2017, Napoli Stewart - - PowerPoint PPT Presentation

Jun 08, 2023 343 likes •501 views

Monte Carlo calculation of RBE and in-vitro validation for helium ion-beam therapy MCMA 2017, Napoli Stewart Mac Mein PhD Student German Cancer Research Center (DKFZ) Translational Radiation Oncology Group Dr. Amir Abdollahi

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SLIDE 1

Monte Carlo calculation of RBE and in-vitro validation for helium ion-beam therapy

Stewart “Mac” Mein PhD Student German Cancer Research Center (DKFZ) Translational Radiation Oncology Group — Dr. Amir Abdollahi Heidelberg Ion-beam Therapy Center (HIT) Biophysics in Particle Therapy Group — Dr. Andrea Mairani

MCMA 2017, Napoli

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SLIDE 2

✦ Comprehensive dosimetric characterization @ HIT ✦ Validation of Monte Carlo Tx Planning (MCTP) platform ✦ Preliminary plan comparisons (p. vs. He)

Meningioma cases (He)

Tessonnier et al 2017

physical + biological

a b

Helium @ HIT

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SLIDE 3

model surviving fraction (SF)

RBE(Dose, LET, [α/β]ph)

Chaudhary et al 2014

RBE Prediction

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SLIDE 4

1) Biophysical models (Theoretical)

  • MKM = Microdosimetric Kinetic Model
  • LEM = Local Effect Model

2) Phenomenological (Experimental)

  • “Data-driven”
  • Interpretation of collected data from the

literature

Methods:

proton heavy ions

RBE Prediction

Durante et al 2017

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SLIDE 5

RBE Prediction

FLUKA-coupled Dbio Calculation

p C

1999 2010 2016

He

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SLIDE 6

2016a 2016b

Phenomenological Approach

1. 2. 3.

parameterization Experimental validation Model Comparisons

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SLIDE 7

RBE models in 4-He ion beam therapy: predictions in clinically- relevant scenarios

RBE Prediction

2017 clinical relevance (α/β)γ (α/β)γ LET LET

RBE(Dose, LET, [α/β]ph)

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SLIDE 8

RBE Model Validation

Clonogenic Assay with Pristine Peaks: RenCa cell-line

  • Photon:[1 to 8 Gy]
  • Determination of alpha (αph) and beta (βph)
  • 4He beam delivery: [0.25 to 3.3 Gy]
  • EHe =56.65 MeV/u, BP depth = 24 mm
  • Biol. measurements: 6 and 21mm
  • FLUKA simulations: Deff [DD, MKM, LEM-IV]

Mein et al 2017 @ PTCOG

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SLIDE 9

RBE Model Validation

High-throughput Clonogenic Assay — Clinical-like Fields (SOBPs)

96 well plate approach (as in Guan et al 2015)

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SLIDE 10

RBE Model Validation

High-throughput Clonogenic Assay — Clinical-like Fields (SOBPs) H1460 cell-line αph/βph = 5.8 Klein et al 2017 (under revision)

  • Validity of 96-well plate
  • high-throughput approach
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SLIDE 11

Application

Validation of clinical TPS

Validation against FLUKA — SOBPs in water

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SLIDE 12

FROG FLUKA FLUKA [PHYS] FROG [BIO]

Validation of clinical TPS

  • ptimized via MCTP

FLUKA FROG Meningioma cases (He)

65 Dose [Gy]

[PHYS] [BIO]

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SLIDE 13

Summary

comprehensive characterization and benchmarking:

  • He4 RBE prediction with Dbio calc in FLUKA
  • physical and biological calculation of FROG (in-

house TPS) and future commercial TPS Preparation for first He4 treatments

Tessonnier et al 2017 (under review)

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SLIDE 14

German Cancer Research Center (DKFZ) Translational Radiation Oncology Group

  • Dr. Amir Abdollahi
  • Dr. Ivana Dokic

Carmen Klein Heidelberg Ion-beam Therapy Center (HIT)

  • Dr. Stephan Brons

Benjamin Ackerman

  • Dr. Thomas Haberer

LMU

  • Dr. Katia Parodi
  • Dr. Thomas Tessonnier

Heidelberg University Clinic

  • Dr. Jurgen Debus

Biophysics in Particle Therapy Group

  • Dr. Andrea Mairani

Benedikt Kopp

  • Dr. Julia Bauer
  • Dr. Emanuel Bahn
  • Dr. Markus Alber

CNAO Kyungdon Choi

  • Dr. Giuseppe Magro

Acknowledgments