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Update on Latest Research Update on Latest Research in Prevention and in Prevention and Treatment of Dementia Treatment of Dementia
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Update on Latest Research Update on Latest Research in Prevention - - PowerPoint PPT Presentation
Update on Latest Research Update on Latest Research in Prevention - - PowerPoint PPT Presentation
Update on Latest Research Update on Latest Research in Prevention and in Prevention and Treatment of Dementia Treatment of Dementia
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Can we prevent dementia? Can we prevent dementia?
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Causes of dementia Causes of dementia
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Established risk factors for Established risk factors for developing AD developing AD
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Probable risk factors for AD Probable risk factors for AD
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Possible risk factors for AD Possible risk factors for AD
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Possible risk factors for AD Possible risk factors for AD
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Probable protective factors for Probable protective factors for developing AD developing AD
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Possible protective factors for Possible protective factors for developing AD developing AD
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Possible protective factors for Possible protective factors for developing AD developing AD
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Risk factors for progression to Risk factors for progression to dementia dementia
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Risk factors for progression to Risk factors for progression to dementia dementia
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CAIDE Dementia Risk Score CAIDE Dementia Risk Score
Age Age < 47 years < 47 years 47 47-
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53 years >53 years >53 years 3 3 4 4 Formal education Formal education
- 10 years
10 years 7 7-
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9 years 0-
- 6 years
6 years 2 2 3 3 Sex Sex Women Women Men Men 1 1 Systolic BP Systolic BP ≤ ≤ 140 mm Hg 140 mm Hg > 140 mm Hg > 140 mm Hg 2 2 BMI BMI ≤ ≤ 30 kg/m2 30 kg/m2 > 30 kg/m2 > 30 kg/m2 2 2 Total cholesterol Total cholesterol ≤ ≤ 6.5 6.5 mmol/l mmol/l > 6.5 > 6.5 mmol/l mmol/l 2 2 Physical activity Physical activity Active Active Inactive Inactive 1 1
Kivipelto et al., Lancet Neurol 2006
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Probability of dementia in late Probability of dementia in late-
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life according to the risk score category in according to the risk score category in middle age middle age
SCORE SCORE Demented/All Demented/All % Risk (95% CI) % Risk (95% CI) 0-
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15 20/122 20/122 16.4 (9.7 16.4 (9.7-
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23.1) The overall occurrence of dementia 4.4% The overall occurrence of dementia 4.4%
Kivipelto et al., Lancet Neurology 2006
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The The culinotherapy culinotherapy approach to approach to prevention prevention
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Treatment of dementia Treatment of dementia
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Management of mild to moderate Management of mild to moderate dementia dementia
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Symptomatic Treatment of AD Symptomatic Treatment of AD
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Natural history of Alzheimer Natural history of Alzheimer’ ’s disease s disease and future stage and future stage-
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specific interventions Severity of the disease
Normal Aging Amnestic M C I Loss of some functional independence Behavioural symptoms Nursing home placement Death
1 2 3 4 5 6 7 8
Control of vascular risk factors; healthy diet; physical and intellectual exercises Cognitive training; anti-amyloid Rx or statins based on age and genotypes ChEI Memantine Memantine ChEI Atypical neuroleptics Memantine Atypical neuroleptics
Time (years)
Diagnosis of AD Antidepressants ChEI
Modified by Gauthier 2009 from Jelic & Winblad, 2004
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Future treatments Future treatments
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