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Update on ACL Graft Selection Paul Marchetto, MD Associate - PowerPoint PPT Presentation

Update on ACL Graft Selection Paul Marchetto, MD Associate Professor Orthopaedic Surgery Thomas Jefferson University Rothman Institute ACL Graft Selection ACL reconstruction is the : 6th most common procedure performed in Orthopedic


  1. Update on ACL Graft Selection Paul Marchetto, MD Associate Professor Orthopaedic Surgery Thomas Jefferson University Rothman Institute

  2. ACL Graft Selection  ACL reconstruction is the :  6th most common procedure performed in Orthopedic Surgery  100,000 ACL reconstruction per year  85% of surgeons doing ACL surgery do < 10/yr  Failure rate estimated at 10- 15%

  3. ACL Graft Selection  The ideal graft should  Reproduce native anatomy and normal biomechanics  Rapidly incorporate with strong initial fixation  Low donor site morbidity  Limit risk of disease transmission  Allow for sufficient graft length and diameter  Be cost effective

  4. ACL Graft Selection  Important variables to consider in ACL surgery  Graft selection  Graft fixation  Tunnel placement  Functional rehabilitation

  5. ACL Graft Selection  Bone Patella Bone Autograft was considered the “Gold Standard” for graft choice - this is rapidly changing  With the evolution of ACL surgical technique and improvements in technology, there is more variability in graft choice  With no “Gold Standard” it is important when choosing a graft, to understand the advantages and disadvantages of each.

  6. ACL Graft Selection  Autograft  Bone - Patellar - tendon bone  Semitendinosis and Gracilis  Quadriceps tendon

  7. ACL Graft Selection  Allograft  Bone patellar-tendon bone  Semitendinosis Gracilis  Achilles tendon  Quadriceps tendon

  8. Criteria for ACL graft selection  Biomechanics of normal ACL and ACL Graft  All current auto/allograft choices have higher ultimate strength than native ACL  Biological Healing  BPTB autograft incorporate into bone tunnels as early as 6 weeks  Hamstring autograft – 12 weeks  Allograft as much as 6 months

  9. Criteria for ACL graft selection  Ease of harvest  Operative time: BPTB auto is the most difficult  Hamstring is faster to harvest  There is a learning curve to all types of graft harvesting with added potential for complications  Return to play  Surgeon dependent  Lack of objective evidence in decision criteria for return to play

  10. Criteria for ACL graft selection  Donor site morbidity  BPTB auto > QT auto > Hamstring auto  Donor site complications  Fracture of patella  Nerve injury with hamstring harvest  Anterior knee pain

  11. Outline  Graft Choices  Autograft o Patella Tendon o Hamstring o Quadriceps Tendon  Allograft o Patella Tendon o Achilles Tendon o Soft Tissue Allograft  Tibialis  Hamstring o Sterilization

  12. Biomechanical Properties Graft Ultimate Stiffness Cross Sectional Area (mm 2 ) Strength (N) (N/mm) Intact ACL 2160 242 44 BPTB (10 mm) 2977 620 50 QDHS 4590 861 53 Quad Tendon 2352 463 62 (10 mm) Anterior Tibial 3412 344 38 Tendon (single) Posterior Tibial 3391 302 48 Tendon (single) All grafts have higher strength & stiffness than native ACL

  13. Grafts - Autograft  Bone-patella tendon-bone  Pros o Most likely quickest healing o Excellent fixation o Good track record (results 90- 95%) o Strength of graft  Cons o Linked to PF pain & DJD o Risk of patella fracture o Patella Tendon rupture o Larger incision o More painful surgery

  14. Grafts - Autograft  Hamstrings (Semitendinosis / Gracilis)  Pros o Strongest tensile strengths (>4000 N) o Smaller incision o Pediatric patient o ? Hamstring regrowth  Cons o ? Fixation strength o Residual muscle weakness o Soft tissue to bone healing o Harvest – possible short graft o Graft size - diameter

  15. Grafts - Autograft  Quadriceps Tendon  Pros o Similar tensile strength to BPTB o Fixation similar to BPTB o Less anterior knee pain

  16. Grafts - Autograft  Quadriceps Tendon  Cons o Longer Incision o Less experience o Quad tendon weakness

  17. Autograft Results  BPTB vs. Hamstring  No study to date demonstrated a superiority of any graft source in stability and functional outcomes  Morbidity of hamstring graft harvest is less than the morbidity of bone-patella tendon-bone graft harvest o Laxdal et al. (Arthroscopy ’06) o Yasuda et al. (AJSM ‘95)  Anterior knee pain, knee extension loss, kneeling pain & arthritis statistically greater with the use of BPTB grafts compared to HS grafts o Sajovic et al. (AJSM ’06) o Kartus et al. (Arthroscopy ’01)  Recent prospective 5 yr FU study of 2 equally matched groups: statistically higher incidence of OA of the knee in patients BPTB graft (50%) compared to HS graft (17%) o Sajovic et al. (AJSM ’06)

  18. Autograft Results  BPTB vs. Hamstring = Meta-analysis  Yunes et al (Arthroscopy ’01) = 411 patients o BPTB group had significant less laxity by KT-1000 than the hamstring group o BPTB = 18% higher rate of “return to preinjury level of activity”  Freedman et al (AJSM ’03) = 1976 patients o Increased PF pain, less laxity, lower rates of graft failure, improved stability, and higher patient satisfaction in the BPTB group  Prodromos et al (Arthroscopy ’05) = 56 studies o HS group = higher stability depending on fixation type  Goldblatt et al (Arthroscopy ’05) = 1039 patients o Anterior knee pain, increased kneeling pain, flexion deficit with BPTB autograft and extension deficit compared with HS autograft o BPTB more likely to result in normal Lachman exam, pivot shift exam, KT-1000 side-to-side difference <3mm, and fewer results with significant flexion loss

  19. Autograft Results  BPTB vs. Quad Tendon  Staubli et al ( AJSM ’99) o BPTB > tensile strength  Lee et al. ( Arthroscopy ’04) o Comparable results of BPTB vs. Quad

  20. Autograft Results  Comparison of all 3  Joseph et al. (Orthopaedics ’06) o Early comparison of 3 autografts o Free quad tendon group achieved earlier full knee extension o Less pain with quad tendon o Similar clinical results

  21. Grafts - Allograft  Public concern for disease transmission Biomedical Tissue Services (BTS) 2008  “Dentist Pleads Guilty to Stealing and Selling Body Parts”  Acquiring body parts from funeral homes without proper screening and consent

  22. Grafts - Allograft  Disease transmission and infection  American Association of Tissue Banks  AATB

  23. AATB Screening guidelines  Consent  History of donor  Prior infections  Risk factors (homosexuality, sex for money,illegal drug use, hemophilia)  Physical Exam  Needle wounds  Infection

  24. AATB Screening guidelines  Screening Tests on Blood and Tissue  Donors must test negative for antibodies to (HIV)  Nucleic acid test (NAT) for HIV-1  Hepatitis B surface antigen  Antibody to hepatitis B core antigen  Antibodies to the hepatitis C virus (HCV)  Nucleic acid test (NAT) for HCV  Antibodies to T-lymphotropic virus, and syphilis

  25. AATB Screening guidelines  Nucleic acid testing for HIV and HCV  A new provision of the AATB as of March 9, 2005  Nucleic acid testing markedly shortens the window of time for the detection of the viruses.

  26. AATB guidelines  Tissue excisions must commence within 24 hours of asystole if the body was cooled  Within 15 hours of death if the body was not cooled  An aseptic technique is used to retrieve all tissues  Tissues are cultured after harvest and prior to processing  All musculoskeletal tissues are processed in a bacteriologically controlled and climate- controlled environment

  27. Secondary Sterilization  Eliminate all possibility of infection while maintaining all biologic and mechanical properties of the tissue  No technique currently exists that fulfills these requirements  Gamma irradiation is a popular method  2.5 megarads w/o significantly altering biomechanical properties of graft  Eliminating bacterial surface contamination

  28. Grafts - Allograft  The estimated risk for HIV transmission with a connective tissue allograft is estimated to be 1:8,000,000  CDC reported 26 cases of allografts associated bacterial infections in an estimated 1 million musculoskeletal allograft  The majority of infected grafts were from tissues processed by the same tissue bank. This tissue bank was closed.  All were processed aseptically  None were terminally sterilized

  29. Allograft storage options  Fresh Frozen allografts  between temperatures of -80 to -196 degrees F  allows for storage of up to 3 to 5 years,  the process kills the cells.  Cryopreservation  tissue undergoes controlled-rate freezing  cellular water is extracted by glycerol and dimethylsulfoxide.  shelf life of 10 years and up to 80% of cells can remain viable.

  30. Allograft storage options  Freeze drying or lyophilization  Residual moisture level of <5%.  Stored at room temperature for up to 3 to 5 years.  Requires rehydration

  31. Grafts - Allograft  Bone-patella tendon-bone  Pros o Bone – bone healing o Graft size o Fixation o Incision size o Shorter OR time o Less post-op pain  Cons o Risk of infection o Slower healing o Cost o Availability

  32. Grafts - Allograft  Achilles tendon  Pros o Bone – bone healing on femur o Size of graft o Ease of retroscrew fixation o Smaller incision o Shorter OR time o Less post-op pain  Cons o Risk of infection o Slower healing o Cost o Availability

  33. Grafts - Allograft  Soft tissue (hamstring / tibialis)  Pros o Graft strength o Variability in size o Smaller incisions o Less post-op pain o Shorter OR time

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