SLIDE 1
HIV-Grade Tools
HIV-1
- NNRTI
- NRTI
- PI
- Fusion (gp41)
- InSTI
- [Coreceptor geno2pheno]
HBV HCV with geno2pheno HIV-2
- --
- NRTI
- PI
- --
- InSTI
- [Coreceptor geno2pheno]
Update 2017 HIV-Grade Tools HIV-1 HIV-2 NNRTI -- NRTI NRTI PI - - PowerPoint PPT Presentation
Update 2017 HIV-Grade Tools HIV-1 HIV-2 NNRTI -- NRTI NRTI PI - - PowerPoint PPT Presentation
Josef Eberle Update 2017 HIV-Grade Tools HIV-1 HIV-2 NNRTI -- NRTI NRTI PI PI Fusion (gp41) -- InSTI InSTI [Coreceptor geno2pheno] [Coreceptor geno2pheno] HBV HCV with geno2pheno Pt with
SLIDE 2
SLIDE 3
Pt with haemophilia, 58y, from 1985 HIV-1B, HCV 1989-2015
SLIDE 4
.. still left some PIs, InSTIs, and the CCR5 antagonist
SLIDE 5
Rules set
- Based on
–publications –treatment observations –phenotypic lab tests
- Two updates per year
- Differentiated set of ≈ 300 rules
SLIDE 6
Regular up dates for algorithms
- e.g. Doravirin
Which significance have special mutations or their combinations – V106A/M – Y188L – G190A – H221Y – F227L/C – L234I
SLIDE 7
A small glance into the NNRTI world
K103 NHST V106 A Y181 C 181 IV Y188 L Y188 C Y188 H G190 ACEQS G190 TV H221 Y F227 C M230 L L234 I
EFV ETR NVP RPV
SLIDE 8
Work in progress on InSTI algorithms
- For DTG, EVG, RAL
What is the significance of single mutations or combinations of V260I R263K
SLIDE 9
What significance have revertants?
here for ABC: M41L, L210W with T215S
SLIDE 10
HIV-2
- Work on treatment guidelines in cooperation
with German/European professional societies (see presentation by Dirk Berzow)
- Develop and adjust rules for resistance
algorithms (see presentation by Martin Obermeier)
SLIDE 11
How to handle this HIV-2 case: Afrikan, 55y, 8.300 IU/ml..
SLIDE 12
No mutations for InSTIs, two amplicons for the coreceptor region
- 1. with primerset A (weak band)
SLIDE 13
- 2. with primerset B (strong band)
SLIDE 14