Three-dimensional speckle tracking of the Three-dimensional speckle - - PowerPoint PPT Presentation

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Feb 29, 2024 326 likes •409 views

Three-dimensional speckle tracking of the Three-dimensional speckle tracking of the right ventricle : right ventricle : Implications on survival in pulmonary hypertension Implications on survival in pulmonary hypertension Moceri P, Duchateau

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Three-dimensional speckle tracking of the Three-dimensional speckle tracking of the right ventricle : right ventricle : Implications on survival in pulmonary hypertension Implications on survival in pulmonary hypertension

Moceri P Moceri P, Duchateau N, Baudouy D, Leroy S, Bouvier P, Schouver D, Sermesant M, Ferrari E.

Cardiology Department, CHU de Nice, FR Asclepios Research Project, INRIA, Sophia-Antipolis

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Declaration of Interest Declaration of Interest

No conflict of interest
Funding sources:

– University hospital of Nice, France (AO2I 2013; AOI 2014) – European Union 7th Framework Programme (VP2HF FP7-2013-611823) – European Research Council (MedYMA ERC-AdG-2011-291080)

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Background / Objectives Background / Objectives

Survival in PH relates to RV function
2D analysis of RV anatomy and structure is limited
Little is known about 3D RV global and regional function

3D RV deformation differences between healthy controls and PH adult patients ? Implications of global and regional 3D RV shape and deformation on clinical condition and survival in PH ?

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Methods Methods

Prospective cohort

study

104 PH patients
34 healthy controls

3D Echo 3D Echo Inclusion Inclusion End of study

Follow-up

TomTec 4D RV Function 2.0

Non commercial software
Temporal alignment
Regional and global motion

and deformation

3D RV area strain

Post-processing of 3D RV meshes

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Results Results

Highest deformation : lateral and inferior wall

p<0.001

RV shape and deformation related to NYHA class
Gradual RV dilatation

– Spherical RV shape in advanced PH patients

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Results (2) Results (2)

Median follow-up : 6.7 months [5.8-7.2]

– 16 patients (15.4%) died from PH

RV Global area strain > - 18%

– Independent predictor of survival – Identifies high-risk PH patients with a 48%-increased risk of death

ICC for inter-observer variability : 0.90

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Perspectives Perspectives

RV shape and strain patterns are gradually deteriorated in PH

– Independent prognostic marker in PH

3D area strain helps understand the RV deformation

– And could help stratifying the risk in PH patients

Conclusion Conclusion

Development of RV-dedicated 3D speckle-tracking software
Generalization and validation of 3D RV study
Development of 3D regional assessment

Thank Thank you you