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ch6p
(MHC)
Human Leucocyte Antigens (HLA)
The Major Histocompatibility Complex Histocompatibility Complex - - PowerPoint PPT Presentation
The Major Histocompatibility Complex Histocompatibility Complex - - PowerPoint PPT Presentation
The Major Histocompatibility Complex Histocompatibility Complex (MHC) (MHC) ch6p Human Leucocyte Antigens (HLA)
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ch6p
(MHC)
Human Leucocyte Antigens (HLA)
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MHC
polygenic: 9 main genes (DP〈 / , DQ〈 / , DR〈 / , B, C, A) polygenic: 9 main genes (DP〈 / , DQ〈 / , DR〈 / , B, C, A) polymorphic: multiple alleles for each gene codominant: both maternal and paternal alleles expressed
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- α
β
- β
α β ! "α #$%& "β
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Alloantigens: non-self MHC molecules. 1-10% of all T lymphocytes recognizes allogenic MHC - transplant rejection Superantigens: bacterial or viral proteins/lipid/sugars that associate extracellularly with the MHC-II and are recognized by 5-10% of all T lymphocytes - endotoxic shock
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)
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γ γ γ γ")""
*-'(-,'++('%'(9'( #++3& γ+=7'%'%(.% 13/%'%-('/%) '*'%-*
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MHC-Ib recognition by NK cells
- MICA and MICB on epithelial cells are
recognized by the complex DAP10/NKG2D on NK cells (activatory DAP10/NKG2D on NK cells (activatory signal)
- HLA-G and HLA-E are recognized by