Task & Finish Group Total Error Wytze Oosterhuis Task & - - PowerPoint PPT Presentation
Task & Finish Group Total Error Wytze Oosterhuis Task & Finish Group Total Error Terms of Reference: To come up with a proposal for how to use the total error concept and how to possible combine performance specifications for bias and
Terms of Reference: To come up with a proposal for how to use the total error concept and how to possible combine performance specifications for bias and imprecision. Deliverable: A manuscript dealing with this topic. Task & Finish Group Total Error
Members: Dave Armbruster (US) Hassan Bayat (IR) Patrick Bossuyt (NL) Abdurrahman Coskun (TR) Peter Deman (NL) Ana-Paula Faria (PT) Kathleen Freeman (UK) Per Hyltoft-Petersen (DK) Anders Kallner (SW) Dave Koch (US) Finlay MacKenzie (UK) Gabriel Migliarino (AR) Matthias Orth (DE) Hanna Ritzen (SW) Marit Sverresdotter Sylte (NO) Johan Surtihadi (US) Elvarr Theodorsson (SW) Sten Westgard (US)
Task & Finish Group Total Error
Problems: Conventional model is flawed: TEA = 0,25CVB + 1,65(0,5CVI) Summing of mutual exclusive terms.
Clinical Chemistry 57:9 (2011)
Task & Finish Group Total Error
Task & Finish Group Total Error
Other problems:
In general Maximum imprecision CVA < 0.5CVB Maximum bias < 0.25CVB Monitoring Maximum imprecision CVA < 0.5CVI Maximum bias < 0.25(CVI
2+CVG 2)1/2
Diagnosis? Maximum imprecision CVA < 0.5(CVI
2+CVG 2)1/2
Maximum bias < 0.25(CVI
2+CVG 2)1/2
Task & Finish Group Total Error
Task & Finish Group Total Error
Task & Finish Group Total Error
Task & Finish Group Total Error
Method Ideal performance specification (e.g. for manufacturer) Realistic IQC-limits Method performance Sigma metrics can be calculated CVa<½CVi
+
theory)
+ + (-) + +
Gowans
+
+
(Oosterhuis/Sandberg)
+ +
RiLiBAK
+
uncertainty
quality goals?
performance? Task & Finish Group Total Error