Task & Finish Group Total Error Wytze Oosterhuis Task & - PowerPoint PPT Presentation

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Task & Finish Group Total Error Wytze Oosterhuis Task & Finish Group Total Error Terms of Reference: To come up with a proposal for how to use the total error concept and how to possible combine performance specifications for bias and

Task & Finish Group Total Error Wytze Oosterhuis
Task & Finish Group Total Error Terms of Reference: To come up with a proposal for how to use the total error concept and how to possible combine performance specifications for bias and imprecision. Deliverable: A manuscript dealing with this topic.
Task & Finish Group Total Error Members: Dave Armbruster (US) Hassan Bayat (IR) Patrick Bossuyt (NL) Abdurrahman Coskun (TR) Peter Deman (NL) Ana-Paula Faria (PT) Kathleen Freeman (UK) Per Hyltoft-Petersen (DK) Anders Kallner (SW) Dave Koch (US) Finlay MacKenzie (UK) Gabriel Migliarino (AR) Matthias Orth (DE) Hanna Ritzen (SW) Marit Sverresdotter Sylte (NO) Johan Surtihadi (US) Elvarr Theodorsson (SW) Sten Westgard (US)
Task & Finish Group Total Error Problems: Conventional model is flawed: TE A = 0,25CV B + 1,65(0,5CV I ) Summing of mutual exclusive Clinical Chemistry 57:9 (2011) terms.
Task & Finish Group Total Error
Task & Finish Group Total Error Other problems : In general Maximum imprecision CV A < 0.5CV B Maximum bias < 0.25CV B Monitoring Maximum imprecision CV A < 0.5CV I Maximum bias < 0.25(CV I 2 +CV G 2 ) 1/2 Diagnosis? Maximum imprecision CV A < 0.5(CV I 2 +CV G 2 ) 1/2 Maximum bias < 0.25(CV I 2 +CV G 2 ) 1/2
Task & Finish Group Total Error - Correct of bias - Take all sources of uncertainty into account
Task & Finish Group Total Error
Task & Finish Group Total Error CLSI
Ideal performance Sigma metrics Realistic Method Method specification (e.g. can be IQC-limits performance for calculated manufacturer) + - + - CVa<½CVi Total error (conventional + + (-) + + theory) + - + - Gowans + - + - RCV (Larsen) Adapted Gowans/RCV - + (-) + + (Oosterhuis/Sandberg) - + + - RiLiBAK - - + - CLSI - - + - GUM ISO Draft measurement - - + - uncertainty
Task & Finish Group Total Error Questions: - What is the minimum analytical performance? - What are realistic performance goals? - How can a Internal Quality Control scheme be derived from quality goals? - How can we calculate one measure for analytical performance?

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