T H E N E U R O B I O L O G Y O F G R E A T N E S S STRUCTURE PRESENTATION
THE STAGES OF LIFE
B I O L O G I C A L F U N C T I O N S D E C R E A S E W I T H T I M E 100 N E R V E C O N D U C I N G V E L O C I T Y MAXIMUM HEART RATE PERCENTAGE OF PERFORMANCE KIDNEY BLOOD FLOW 80 M MAXIMUM WORK RATE (OXYGEN UPTAKE) A X I M U M 60 B R FEMALE FERTILITY E A T H I N G C A P A C I T Y 40 20 20 35 50 65 80 AGE IN YEARS
T H E E X T E N S I O N O F M O R B I D I T Y
AGING IS NOT WRITTEN IN OUR DNA Aging happens not because "genes for ageing" do something , but because "genes for somatic maintenance" , which act as "longevity assurance, stop doing something. T.B.KIRKWOOD T H E D I S P O SA B L E S O M A T H E O RY Can we keep genes working for a little longer? some people do...other don't STRUCTURE PRESENTATION
T H E C O M P R E S S I O N O F M O R B I D I T Y
WHO DEFINITION OF HEALTH "Health is a state of complete physical, mental and social wellbeing and not merely an absence of disease or infirmity." (1948) now added--> "the ability to lead a socially and economically productive life. " (1984) •The concept of health as defined by WHO is broad and positive in its implications; it sets out the standard, the standard of "positive" health.
H E A L T H I S N O T T H E A B S E N C E O F D I S E A S E PSYCO RELATIONSHIP PHYSICAL HEALTH SELF REALIZATION PERSONAL FREEDOM
WHICH FACTORS INFLUENCE OUR HEALTH? 1 0 % ACCESS TO CARE 2 0 % GENETICS 5 0 % 2 0 % HEALTH BEHAVIORS ENVIRONMENT Source IFTF Centers of Disease Control and Prevention
WHAT REGULATES HAPPINESS 90% OF OUR HAPPINESS DEPENDS ON THE INTERACTION BETWEEN A 4 0 % GENETIC SET POINT AND DAILY H A B I T S HABITS 5 0 % G E N E T I C S E T P O I N T 1 0 % E V E N T S
GOOD GENES ARE NICE, BUT JOY IS BETTER
E P I G E N E T I C S R E G U L A T E S A D A P T A T I O N A N D A G I N G Exercise
GREATNESS COMES FROM OVERCOMING CHALLENGES THROUGH THE ACQUISITION OF SKILLS AND THE ESTABLISHMENT OF GOOD RELATIONSHIPS ALONG THE WAY.
GENOTYPE EPIGENETIC REGULATION PHENOTYPE
REAL HEALTH = HAPPINESS, FULFILLMENT, SATISFACTION. TO WITHIN THE CONTEXT OF THE BEST HEALTH POSSIBILE HEALTH IS NOT A GOAL BUT A TOOL
HAPPINESS= THE EXPECTATIONS YOU HAVE/ THE REALITY YOU BUILD
MANAGING EPIGENETICS + NEUROPLASTICITY = CONTINUED GROWTH AND IMPROVEMENT
PHYSICAL NUTRITION TRAINING 4 THE FOUNDATIONS OF A HEALTHY LIFE MENTAL TRAINING & NUTRITIONAL INNER WORK SUPPLEMENTATION
Science. 2009 Jul 10;325(5937):201-4. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch CALORIC R. RESTRICTION Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness DELAYS DISEASE and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus ONSET AND monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National MORTALITY IN Primate Research Center, moderate CR lowered the incidence of aging- related deaths. At the time point reported, 50% of control fed animals RHESUS MONKEYS. survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species .
Science. 2009 Jul 10;325(5937): 201-4. CALORIC RESTRICTION DELAYS DISEASE ONSET AND MORTALITY IN RHESUS MONKEYS.
H O R M E T I C S T I M U L A T I O N CELLULAR PROTECTION HEAT SHOCK PROTEIN EXPRESSION GLUCOSE-REGULATED PROTEINS TROPHIC FACTOR SUPPORT PI3K-AKT ACTIVITY JINK ACTIVITY HORMETIC RESPONSE TRANSCRIPTIONAL PROTECTION REDUCED GLUCOSE TO CR REDUCED ATP ALTERED ENERGY STORES SIRTUIN ACTIVITY REDUCED MASS PPAR ACTIVITY HUNGER NF-NB ACTIVITY PGC1-TI REGULATION FOXO TRANSCRIPTION REGULATION SOMATIC PROTECTION KETOGENESIS EUGLYCEMIA IRNMUNOMODULATION INSULIN SENSITIVITY Fig. 1 Calorie restriction as a hormetic effector of multiple protective mechanisms. The induction of caloric restriction (CR) imposes a myriad of challenges to the body. To maintain survival and well-being in the face of the reduced capacity to produce and store energy for growth, reproduction, or homeostasis, the body responds to the CR state with a "hormetic-style" response. Hence, responsive mechanisms at multiple physiological levels are entrained to ameliorate and even employ the applied CR stress to the benefit of the body. These mechanisms occur at almost all levels of cellular and tissue organization—for example, with respect to maintenance of intermediary cell metabolism (cellular protection), generation of new proteins (transcriptional protection), and maintenance of whole-body endocrine/neurological axes (somatic protection)
S T R AT E G I E S TO I M P R O V E N U T R I T I O N S U G A R E L I M I N AT E R E F I N E D C E R E A L S C H A N G E W I T H W H O L E G R A I N FAT S U S E H E A L T H Y O N E S V E G E TA B L E S I N C R E A S E P R O T E I N S U S E H E A L T H Y O N E S DO S E S /C A L O R I E S R E D U C E
S T R AT E G I E S TO M A N AG E F O O D S U P P L E M E N T S M E TA B O L I C O P T I M I Z AT I O N M U L T I V I TA M I N V I TA M I N D I M M U N E S Y S T E M S U P P O R T I N F L A M M ATO R Y R E G U L AT I O N O M E G A 3 O X I DAT I V E S T R E S S M A N AG E M E N T C O E N Z Y M E Q 1 0 I S O L AT E D W H E Y P R O T E I N S M U S C L E R E C O V E R Y
S T R AT E G I E S F O R P H Y S I C A L T R A I N I N G M U S C L E S A N D B O N E S W E I G H T S H E A R T A N D L U N G S WA L K I N G , J OG G I N G , B I K I N G , E TC M O B I L I T Y A N D F L E X I B I L I T Y S T R E TC H I N G , P I L AT E S
GENOTYPE CHOICES | PRACTICES | HABITS | RITUALS X TIME PHENOTYPE
W E A R E B O R N N E U R O L O G I C A L L Y " E M P T Y "
W E N E E D T O T R A I N O U R M O S T I M P O R T A N T T O O L PHYSICAL NUTRITION TRAINING 4 THE FOUNDATIONS TO A HEALTHY LIFE MENTAL NUTRITIONAL TRAINING & SUPPLEMENTATION INNER WORK
Table 17-1. Biomedical and underlying causes of death in the United States in 1990 Top Ten Biomedical Determinants Cardiovascular disease Cancer Cerebrovascular disease Chronic obstructive pulmonary disease Unintentional injury Pneumonia and influenza Diabetes HIV/AIDS Suicide Homicide Top Ten Underlying Causes* Tobacco Poor diet Lack of exercise Alcohol Infectious agents Pollutants/Toxins Firearms Sexual behavior Motor vehicles Illicit drug use Source: McGinnis, J. M., and Fcege. W. H. Review_ Actual causes of death in the United States.Journal of the American Medical Association (November 10) 1993: 270(18)2207-2212.
NEUROPLASTICITY I S T H E B R A I N ’ S E P I G E N E T I C A DA P TAT I O N . AS T H E MUSC LE S O F O UR BO DY , T H E B R A I N A DA P T S TO I N P U T S BAD IS EASIER THAN GOOD
TRAINING CAN MAKES US OVERCOME THE 4 OBSTACLES TO THE 4 OBSTACLES TO GREATNESS GREATNESS DISTRACTIONS AND TEMPORAL INCONSISTENCY AND LOSS OF FOCUS BAD HABIT INSTALLATION 4 THE OBSTACLES TO GREATNESS TIREDNESS AND HYPERVIGILANCE DECISION FATIGUE AND HYPOSATISFACTION
TEMPORAL INCONSISTENCY: MORE IMPORTANCE TO SHORT TERM SATISFACTION THAN TO LONG TERM BENEFITS
THE EVOLUTION OF THE BRAIN: CONFUSION AND INCOHERENCE BETWEEN DIFFERENT LEVELS OF ORGANISATION PALEOMAMMALIAN NEOCORTICAL REPTILIAN BRAIN BRAIN BRAIN RESPIRATION … ASSOCIATIVE MEMORY, DISCRIMINATION, REASONING… EMOTION… SURVIVAL SELF-REALIZATION
03 3rd Brain (high level control) LEVELS OF Fine perception Differentiation of thoughts & feelings BRAIN Discrimination of appropriate behaviour Self-reflection, self-awareness ORGANISATION Problem-resolution FORESIGHT Goal Satisfaction 02 2nd Brain (mid level control) Territoriality Fear Anger Attack Maternal Love HINDSIGHT Anxiety, Hate, Jealousy 01 1st Brain (low level control) Hormonal control Temperature control Respiration & heart rate, BP control Reproduction drive Approach / avoidance REFLEX / INSTINCT Hunger / Thirst control
HOW ARE HABITS FORMED Threshold Deliberate practice or unaware repeated exposure
HABITS ARE A NEURO-ANATOMICAL ADAPTATION
BEHAVIORS ARE LINKED TO REWARD SYSTEMS FOOD, REPRODUCTION, INFORMATION SEEKING
GENE DRD4-7R NOVELTY EXPLORATION RISK TAKING + (IN THE MODERN WORLD) DISTRACTIONS+TEMPTATIONS
EVOLUTIONARY DISCORDANCE VULNERABILITY TO BAD CHOICES
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