T H E N E U R O B I O L O G Y O F G R E A T N E S S STRUCTURE - - PowerPoint PPT Presentation

STRUCTURE PRESENTATION

T H E N E U R O B I O L O G Y O F G R E A T N E S S

THE STAGES OF LIFE

100 80 60 40 20 20 35 50 65 80

AGE IN YEARS PERCENTAGE OF PERFORMANCE

FEMALE FERTILITY MAXIMUM WORK RATE (OXYGEN UPTAKE) M A X I M U M B R E A T H I N G C A P A C I T Y KIDNEY BLOOD FLOW MAXIMUM HEART RATE N E R V E C O N D U C I N G V E L O C I T Y

B I O L O G I C A L F U N C T I O N S D E C R E A S E W I T H T I M E

T H E E X T E N S I O N O F M O R B I D I T Y

STRUCTURE PRESENTATION

T.B.KIRKWOOD

T H E D I S P O SA B L E S O M A T H E O RY

Aging happens not because "genes for ageing" do something, but because "genes for somatic maintenance", which act as "longevity assurance, stop doing something.

AGING IS NOT WRITTEN

IN OUR DNA

Can we keep genes working for a little longer? some people do...other don't

T H E C O M P R E S S I O N O F M O R B I D I T Y

"Health is a state of complete physical, mental and social wellbeing and not merely an absence of disease or infirmity." (1948) now added--> "the ability to lead a socially and economically productive life." (1984)

• The concept of health as defined by WHO is

broad and positive in its implications; it sets

• ut the standard, the standard of "positive"

health.

WHO DEFINITION OF HEALTH

PSYCO PHYSICAL HEALTH RELATIONSHIP SELF REALIZATION PERSONAL FREEDOM

H E A L T H I S N O T T H E A B S E N C E O F D I S E A S E

WHICH FACTORS INFLUENCE OUR HEALTH?

Source IFTF Centers of Disease Control and Prevention

5 0 %

HEALTH BEHAVIORS

2 0 %

GENETICS

2 0 %

ENVIRONMENT

1 0 %

ACCESS TO CARE

90% OF OUR HAPPINESS DEPENDS ON THE INTERACTION BETWEEN A GENETIC SET POINT AND DAILY HABITS

WHAT REGULATES HAPPINESS

1 0 % 4 0 % 5 0 % H A B I T S G E N E T I C S E T P O I N T E V E N T S

GOOD GENES ARE NICE, BUT JOY IS BETTER

Exercise

E P I G E N E T I C S R E G U L A T E S A D A P T A T I O N A N D A G I N G

GREATNESS COMES FROM OVERCOMING CHALLENGES THROUGH THE ACQUISITION OF SKILLS AND THE ESTABLISHMENT OF GOOD RELATIONSHIPS ALONG THE WAY.

GENOTYPE PHENOTYPE

EPIGENETIC REGULATION

REAL HEALTH = HAPPINESS, FULFILLMENT, SATISFACTION.

TO WITHIN THE CONTEXT OF THE BEST HEALTH POSSIBILE

HEALTH IS NOT A GOAL BUT A TOOL

HAPPINESS= THE EXPECTATIONS YOU HAVE/ THE REALITY YOU BUILD

MANAGING EPIGENETICS + NEUROPLASTICITY =

CONTINUED GROWTH AND IMPROVEMENT

THE FOUNDATIONS OF A HEALTHY LIFE

NUTRITION NUTRITIONAL SUPPLEMENTATION PHYSICAL TRAINING MENTAL TRAINING & INNER WORK

4

CALORIC RESTRICTION DELAYS DISEASE ONSET AND MORTALITY IN RHESUS MONKEYS.

• Science. 2009 Jul 10;325(5937):201-4.

Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging- related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.

• Science. 2009 Jul 10;325(5937):

201-4.

CALORIC RESTRICTION DELAYS DISEASE ONSET AND MORTALITY IN RHESUS MONKEYS.

HORMETIC RESPONSE TO CR CELLULAR PROTECTION TRANSCRIPTIONAL PROTECTION SOMATIC PROTECTION

HEAT SHOCK PROTEIN EXPRESSION GLUCOSE-REGULATED PROTEINS TROPHIC FACTOR SUPPORT PI3K-AKT ACTIVITY JINK ACTIVITY SIRTUIN ACTIVITY PPAR ACTIVITY NF-NB ACTIVITY PGC1-TI REGULATION FOXO TRANSCRIPTION REGULATION KETOGENESIS EUGLYCEMIA IRNMUNOMODULATION INSULIN SENSITIVITY

• Fig. 1 Calorie restriction as a hormetic effector of multiple protective mechanisms. The induction
• f caloric restriction (CR) imposes a myriad of challenges to the body. To maintain survival and

well-being in the face of the reduced capacity to produce and store energy for growth, reproduction,

• r homeostasis, the body responds to the CR state with a "hormetic-style" response. Hence, responsive

mechanisms at multiple physiological levels are entrained to ameliorate and even employ the applied CR stress to the benefit of the body. These mechanisms occur at almost all levels of cellular and tissue organization—for example, with respect to maintenance of intermediary cell metabolism (cellular protection), generation of new proteins (transcriptional protection), and maintenance of whole-body endocrine/neurological axes (somatic protection)

H O R M E T I C S T I M U L A T I O N

S U G A R S T R AT E G I E S TO I M P R O V E N U T R I T I O N E L I M I N AT E C H A N G E W I T H W H O L E G R A I N U S E H E A L T H Y O N E S I N C R E A S E U S E H E A L T H Y O N E S R E F I N E D C E R E A L S FAT S V E G E TA B L E S P R O T E I N S R E D U C E DO S E S /C A L O R I E S

M E TA B O L I C O P T I M I Z AT I O N

S T R AT E G I E S TO M A N AG E F O O D S U P P L E M E N T S

M U L T I V I TA M I N V I TA M I N D O M E G A 3 C O E N Z Y M E Q 1 0 I S O L AT E D W H E Y P R O T E I N S

I M M U N E S Y S T E M S U P P O R T I N F L A M M ATO R Y R E G U L AT I O N O X I DAT I V E S T R E S S M A N AG E M E N T M U S C L E R E C O V E R Y

M U S C L E S A N D B O N E S

S T R AT E G I E S F O R P H Y S I C A L T R A I N I N G

W E I G H T S WA L K I N G , J OG G I N G , B I K I N G , E TC S T R E TC H I N G , P I L AT E S H E A R T A N D L U N G S M O B I L I T Y A N D F L E X I B I L I T Y

GENOTYPE PHENOTYPE

CHOICES | PRACTICES | HABITS | RITUALS

X TIME

W E A R E B O R N N E U R O L O G I C A L L Y " E M P T Y "

THE FOUNDATIONS TO A HEALTHY LIFE

NUTRITION NUTRITIONAL SUPPLEMENTATION PHYSICAL TRAINING

4

W E N E E D T O T R A I N O U R M O S T I M P O R T A N T T O O L

MENTAL TRAINING & INNER WORK

Table 17-1. Biomedical and underlying causes of death in the United States in 1990 Top Ten Biomedical Determinants Cardiovascular disease Cancer Cerebrovascular disease Chronic obstructive pulmonary disease Unintentional injury Pneumonia and influenza Diabetes HIV/AIDS Suicide Homicide Top Ten Underlying Causes* Tobacco Poor diet Lack of exercise Alcohol Infectious agents Pollutants/Toxins Firearms Sexual behavior Motor vehicles Illicit drug use Source: McGinnis, J. M., and Fcege. W. H. Review_ Actual causes of death in the United States.Journal of the American Medical Association (November 10) 1993: 270(18)2207-2212.

NEUROPLASTICITY

I S T H E B R A I N ’ S E P I G E N E T I C A DA P TAT I O N . AS T H E MUSC LE S O F O UR BO DY , T H E B R A I N A DA P T S TO I N P U T S

BAD IS EASIER THAN GOOD

THE 4 OBSTACLES TO GREATNESS

THE OBSTACLES TO GREATNESS

TEMPORAL INCONSISTENCY AND BAD HABIT INSTALLATION TIREDNESS AND DECISION FATIGUE DISTRACTIONS AND LOSS OF FOCUS

4

HYPERVIGILANCE AND HYPOSATISFACTION

TRAINING CAN MAKES US OVERCOME THE 4 OBSTACLES TO GREATNESS

TEMPORAL INCONSISTENCY: MORE IMPORTANCE TO SHORT TERM SATISFACTION THAN TO LONG TERM BENEFITS

RESPIRATION… MEMORY, DISCRIMINATION, EMOTION… ASSOCIATIVE REASONING… REPTILIAN BRAIN PALEOMAMMALIAN BRAIN NEOCORTICAL BRAIN

THE EVOLUTION OF THE BRAIN:

CONFUSION AND INCOHERENCE BETWEEN DIFFERENT LEVELS OF ORGANISATION

SELF-REALIZATION SURVIVAL

01 02 03

1st Brain (low level control) Hormonal control Temperature control Respiration & heart rate, BP control Reproduction drive Approach / avoidance Hunger / Thirst control 2nd Brain (mid level control) Territoriality Fear Anger Attack Maternal Love Anxiety, Hate, Jealousy 3rd Brain (high level control) Fine perception Differentiation of thoughts & feelings Discrimination of appropriate behaviour Self-reflection, self-awareness Problem-resolution Goal Satisfaction

FORESIGHT HINDSIGHT REFLEX / INSTINCT

LEVELS OF BRAIN ORGANISATION

HOW ARE HABITS FORMED

Threshold

Deliberate practice or unaware repeated exposure

HABITS ARE A NEURO-ANATOMICAL ADAPTATION

FOOD, REPRODUCTION, INFORMATION SEEKING

BEHAVIORS ARE LINKED TO REWARD SYSTEMS

NOVELTY EXPLORATION RISK TAKING + (IN THE MODERN WORLD) DISTRACTIONS+TEMPTATIONS

GENE DRD4-7R

EVOLUTIONARY DISCORDANCE

VULNERABILITY TO BAD CHOICES

S T R AT E G I E S F O R T E M P O R A L I N C O N S I S T E N C Y & H A B I T S F O R M AT I O N

I M P L E M E N TAT I O N I N T E N T I O N M E D I TAT I O N , J O U R N A L I N G P L A N N I N G AWA R E N E S S E N V I R O N M E N T B I OC H E M I S T R Y P L E A S U R E N O T PA I N AV O I D T R I G G E R S A D D TO E X I S T I N G H A B I T S FAC I L I TAT I O N

Two-fifths of Americans are tired most of the week

TIREDNESS AND DECISION FATIGUE

MORE THAN 20.000 DECISIONS PER DAY?

S T R AT E G I E S F O R T I R E D N E S S A N D D E C I S I O N FAT I G U E

P O W E R N A P M E D I TAT I O N , J O U R N A L I N G P L A N N I N G AWA R E N E S S E N V I R O N M E N T B I OC H E M I S T R Y 8 H O U R S O F S L E E P ( M AY B E 1 0 ) B E C O M E A M I N I M A L I S T D E L E G AT E FAC I L I TAT I O N

12% of users 0-1 hours 1-2 hours 2-3 hours Overall average: 3 hours

AVERAGE DAILY SMARTPHONE SCREENTIME

3-4 hours 4-5 hours 5-6 hours 6-7 hours 7+ hours 22% of users 25% of users 18% of users 12% of users 7% of users 3% of users 1% of users

A M E S S A G E ? ? ( C U R I O S I T Y B O T T O M U P ) S H A L L I C H E C K O R D R I V E ? ( PA U S E ) I M U S T C H E C K A N D I A M G O O D E N O U G H T O D O I T ( T O P D O W N N O T T R A I N E D ) I N T E R F E R E N C E W I T H P R I M A R Y O B J E C T I V E ( D R I V E S A F E L Y ) I S H O U L D N ’ T C H E C K B E C A U S E I T ’ S D A N G E R O U S ( T O P D O W N T R A I N E D )

S T R AT E G I E S F O R D I S T R AC T I O N S A N D L O S S O F F O C U S B L OC K S O F T I M E M E D I TAT I O N , J O U R N A L I N G P L A N N I N G AWA R E N E S S E N V I R O N M E N T FAC I L I TAT I O N B I OC H E M I S T R Y AV O I D B O R E DO M S W I TC H O F F A N D K E E P AWAY DAY S O F D I G I TA L D E TO X

HYPERVIGILANCE & HYPOSATISFACTION

E N V I R O N M E N T external internal N E R V O U S S Y S T E M neuroception S A F E T Y L I F E T H R E AT D A N G E R S O C I A L S T R AT E G I E S eye contact, face expression, posture, tone of voice D E F E N S I V E S T R AT E G I E S fight or flight paralysis to simulate death S U R V I VA L S T R AT E G I E S

+ + + +

• AGGRESSIVE OR DEFENSIVE

BEHAVIORS FRIENDLY AND OPEN BEHAVIORS

SAFETY DANGER

SES SES

HYPERVIGILANCE & THE SOCIAL ENGAGEMENT SYSTEM

HYPERVIGILANCE HYPOVIGILANCE HYPOSATISFACTION COMPENSATION AND SATISFACTION

S T R AT E G I E S F O R H Y P E R V I G I L A N C E A N D H Y P O S AT I S FAC T I O N R E L AT I O N S , E X P E R I E N C E S M E D I TAT I O N , J O U R N A L I N G P L A N N I N G AWA R E N E S S E N V I R O N M E N T FAC I L I TAT I O N B I OC H E M I S T R Y R E L A X AT I O N T E C H N I Q U E S S A F E R E T R E AT B U I L D T R U S T

TRUST IS A POWERFUL THERAPY AGAINST STRESS AND SADNESS

G E N E R O S I T Y F O R G I V E N E S S R E L I A B I L I T Y G O B E Y O N D W O U N D S

PRESENCE, ACTIONS, CURIOSITY, LOVING KINDNESS

H O W TO I M P R O V E T R U S T

G I V E T I M E TO O T H E R S DO W H AT Y O U S AY

CHANGE THE QUALITY OF YOUR INTERACTIONS PHYSICAL CONTACT ACCEPTANCE, GRATITUDE RESPECT PROMISES RESPECT DEADLINES

STRUCTURE PRESENTATION

THE PATH TO GREATNESS

01 02 03

PERSONALIZE THE APPROACH INSTALL ROUTINES AND RITUALS ACQUIRE THE KNOW-HOW

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