SustainLife Business Unit: High Performance Coatings General - - PowerPoint PPT Presentation

SustainLife

Business Unit: High Performance Coatings General Paints

Our World

• 150 million people infected by insect-borne diseases each year
• Annual deaths from Malaria is 2 to 3 million people
• Deaths are mainly in sub-Saharan Africa & South America
• Children under 5 years are the main victims
• Prevention

– Medication – Indoor residual spray – Impregnated Bed Nets – Education

• SustainLife (Insect-X-Term) is part of the solution

SustainLife Coatings

Insect-X-Term D375 A high performance paint incorporating the Anti Malaria insecticide Insect-X-Term HG A high performance paint incorporating Anti Malaria insecticide & Anti-microbial additive (MRSA & E-Coli)

SustainLife Coatings

• The insecticide attacks the nervous system
• Causing
• Disorientation
• Rapid knock-down
• Paralysis
• Death
• The synergist prevents resistance to the insecticide

The Mosquito Kill Mechanism

The role of the Synergist

• PBO is a synergist developed in the 1950’s and is present in all our paint

formulations

• It counteracts the malaria carrying mosquito’s ability to build up a resistance to

Pyrethroids

• Mosquitoes can build up a resistance to Pyrethroids by generating an enzyme which

enables a detoxification of the insecticide. PBO prevents the formation of this enzyme

• In addition PBO enhances the kill rate

Product Safety

• Active ingredients certified & in use globally
• Concentration levels are very low
• Mammalian toxicity is very low

Insecticides

Insect-X-Term D375 Deltamethrin + Synergist Insect-X-Term HG Pyrethroid + Synergist + Anti-microbial additive

Understanding the product

• Eco friendly water-based paint
• Certified to Class 1, Sections 5.4 & 5.5 of the European Standard EN13,300
• 15 to 20 ingredients in the paint. Focus on 3
• Binder: An acrylic resin. GP use only the highest quality

resins and optimise the quantity to maximise durability

• Pigments: Very fine powders (mainly inert)
• Insecticides: Pyrethroids

Understanding the product

Binders & Pigments

• Appropriate selection of resin & pigment type, quality & quantity along with the

correct technology ensures the long term durability of the paint

• The paint is formulated to ensure the resin locks in the pigment and all other

ingredients

• The “locking in effect” depends not only on the resin but also on the choice & ratio of

the other ingredients

Understanding the product

Insecticides

• Were selected based on track record of insect extermination (mosquitoes in particular) and

compatibility of its active components with the resin and other paint ingredients

• The paint has been formulated to ensure a slow release of the insecticides active ingredients
• Efficacy maintained for 3 years due to slow release

SustainLife -- Insect-X-Term

Efficacy

Test results

The following tests were carried out on painted tiles in accordance with the WHO bioassay cone method

WHO bioassay cone Holding cup / glucose

Test results

Humidity Chamber

Test results

Bioassays were carried out at 25 ± 2 oC & 75 ± 10% Relative Humidity 1. According to WHOPES protocols 2. 10 female mosquitoes per replicate test released onto test surface 3. Mosquitoes held inside plugged cone on treated surface for 30 minutes 4. After 30 minutes suction aspirator used to transfer mosquitoes to paper cup 5. Cotton soaked in 10% glucose present in paper cup 6. Cups placed in humidity chamber and held for 24 hours 7. Time percentage mortality recorded

Test results

Testing was carried out at the London University School of Hygiene & Tropical Medicine

Test results for Insect-X-Term D375 % Mortality for the Malaria vector

Mosquito species Anopheles gambiae Control paint no insecticide Insect-X-Term D375 Test 1 ( May 2012) 5% 100% Test 2 (July 2012) 5% 100% Test 3 (July 2012) 5% 99% Test 4 (July 2012) 5% 100% Test 5 (Sept 2012) 5% 94%

Note 1 Extract of results from the London School of Hygiene & Tropical Medicine (LSHTM) Note 2 Testing is ongoing and therefore the results do not imply endorsement of the product by the LSHTM Note 3 Each of the tests 1 to 5 are based on 10 replicates per test. The control is based on 45 replicates

Test results for Insect-X-Term D375 % Mortality for the Dengue vector

Mosquito species Control paint no insecticide Insect-X-Term D375 Anopheles gambiae 5% 100% Replicates 45 10

Note 1 Extract of results from the London School of Hygiene & Tropical Medicine (LSHTM) Note 2 Testing is ongoing and therefore the results do not imply endorsement of the product by the LSHTM

Paint Coverage

Thickness (microns) Coverage (m2/litre) Coverage (m2/kg) Coverage m2/USgallon Coverage ft2/USgallon 50 7 5.4 26.5 279

Product Approvals

• Insect-X-Term D375 is approved by the Pesticide Registration Control Division

(PRCD) in Ireland and allocated a PCS Number. PRCD is a division of the Department of Agriculture, Fisheries & Food

• Insect-X-Term D375 PCS No.96919

Product Approvals

• Certified to EN 13,300 Section 5.5 (Opacity): Class 1
• Certified to EN 13,300 Section 5.4 (Wet Scrub Resistance): Class 1
• Centre for Research in Engineering & Surface Technology (CREST) is the Irish certification

body

• Insecticide active ingredients approved by the PRCD in Ireland
• Insecticide active ingredients approved by the Health & Safety Executive in the UK
• Deltamethrin is an insecticide used by the WHO in their bed net programme
• Insecticide active ingredients approved in a number of countries globally

This product combines the anti-malarial properties of Insect-X-Term with the anti-microbial properties of Hygen General Paints developed Hygen as a secondary defense against bacteria such as the hospital superbug MRSA & E.Coli

SustainLife -- Insect-X-Term HG

Characteristics of Hygen

• Thermal stability
• UV stability
• Inhibits bacterial growth & subsequent colonization
• Active ingredient is silver

SustainLife -- Insect-X-Term HG

SustainLife -- Insect-X-Term HG -- test results

Testing was carried out by the Centre for Research Engineering Surface Technology (CREST) and Dublin Institute of Technology (DIT)

SustainLife -- Insect-X-Term HG -- test results

Hygen paints are tested according to the Japanese standard JIS Z 2801:2000 “Antimicrobial products – Test for antimicrobial activity & efficacy” The test involves exposing 5 cm2 painted panels to bacterial suspensions (MRSA & E.Coli) for 24 hours and monitoring the bacterial inhibition by determining total colony counts and log reduction

SustainLife -- Insect-X-Term HG

Anti-bacterial testing to JIS Z2801

MRSA Resistance JIS Z2801

> 3 log reduction implies 99.9% kill 1 2 3 4 5 6 Before scrub test After scrub test Log Reduction

Log 10 reduction >3: bactericidal, high bacterial kill, little or no growth observed Log 10 reduction <3: bacteriostatic, low or moderate bacterial inhibition, growth observed Bactericidal agents kill bacteria; bacteriostatic agents only slow growth or reproduction

Against Beaumont Hospital MRSA Clinical strain

SustainLife -- Insect-X-Term HG

Clinical trial results --- ward evaluation

Figure 1. Antibacterial activity of four coated walls in two wards at the COPE facility after the 1st sampling event (April 2009).

SustainLife -- Insect-X-Term HG

Clinical trial results --- ward evaluation

Figure 2. Antibacterial activity of four coated walls in two wards at the COPE facility after the 2nd sampling event (Dec 2009).

SustainLife -- Insect-X-Term HG

Hygen at work in Irish hospitals

SustainLife -- Insect-X-Term HG

Hygen - Beaumont Hospital Dublin

SustainLife -- Insect-X-Term HG

Hygen - Our Lady’s Drogheda Hospital

SustainLife -- Insect-X-Term HG

Hygen - COPE Foundation Cork

General Paints’ Development Partners

University of London School of Hygiene & Tropical Medicine Enterprise Ireland Centre for Research in Engineering & Surface Technology (CREST)

SustainLife -- Insect-X-Term -- Summary

• 100% kill rate of the Malaria vector
• Water based premium quality interior paint
• Overcomes pyrethroid resistance
• Longevity of 3 years
• Testing by LSHTM using WHO guidelines
• 60 years experience in the manufacture of premium decorative, industrial & high

technology coatings

• Members of the European & US paint guilds

THANK YOU

General Paints Ltd. Maynooth Road Co Kildare Celbridge Ireland Tel : +353 1 628 8224 Fax : +353 1 627 2205 Email: info@generalpaints.ie Website: www.generalpaints.ie